Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk
Background Inflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk. Design In baseline asses...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2019-12, Vol.23 (10), p.949-957 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 957 |
|---|---|
| container_issue | 10 |
| container_start_page | 949 |
| container_title | The Journal of nutrition, health & aging |
| container_volume | 23 |
| creator | Tay, Jeannie Goss, A. M. Locher, J. L. Ard, J. D. Gower, B. A. |
| description | Background
Inflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk.
Design
In baseline assessments from the CROSSROADS randomized controlled trial, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and C-reactive protein (hs-CRP) were assayed in 163 older adults (37% males, 24% African American, BMI 34±3, age 70±5yrs) with hypertension, dyslipidemia and/or diabetes. Physical function was assessed by sixminute walk test (6MWT), chair sit-and-reach (CSR), hand-grip and knee-extension strength; specific-strength as muscle strength/mass ratio. Analyses included ANCOVA and multiple linear regression adjusted for thigh skeletal muscle (MRI), arm lean mass (DXA) and moderate-to-vigorous intensity physical activity (MVPA; accelerometry).
Results
Higher hs-CRP (p |
| doi_str_mv | 10.1007/s12603-019-1260-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6996491</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2400486549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-fc8fa36638a3823d6cfde3cea228e3c6306088c2cb2b9da3cd19cb959d964d533</originalsourceid><addsrcrecordid>eNqFkkuPFCEUhStG4zz0B7gxJG7clPKo4rExmXScsZNJ2oy6JhRQ3YwUjEBp2l8vPTWOj8S44pDz3QNcbtM8Q_AVgpC9zghTSFqIRHtQbfegOUbsIBjnD6vGTLSMQXbUnOR8DWHXC04fN0cEMY4Y7o6b7-93--y08uB8Drq4GIAKBnwoyYZt2QEXwJX16tYoEazD6NU0LfvqbbyxCZyZ2ZcMvrlasBlsdmV_m7IOOlmVrQErlYyLky1qiN5pcOXy5yfNo1H5bJ_erafNp_O3H1fv2svNxXp1dtnqHpLSjpqPilBKuCIcE0P1aCzRVmHM60oJpJBzjfWAB2EU0QYJPYheGEE70xNy2rxZcm_mYbJG21CS8vImuUmlvYzKyT-d4HZyG79KKmqCQDXg5V1Ail9mm4ucXNbWexVsnLPEXe0sp30n_o8SDAnreQcr-uIv9DrOKdROSIwF73smKK8UWiidYs7Jjvf3RlAehkAuQyDrEMiDkl2tef77g-8rfv56BfAC5GqFrU2_jv536g-qt76N</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2298557968</pqid></control><display><type>article</type><title>Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Alma/SFX Local Collection</source><creator>Tay, Jeannie ; Goss, A. M. ; Locher, J. L. ; Ard, J. D. ; Gower, B. A.</creator><creatorcontrib>Tay, Jeannie ; Goss, A. M. ; Locher, J. L. ; Ard, J. D. ; Gower, B. A.</creatorcontrib><description>Background
Inflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk.
Design
In baseline assessments from the CROSSROADS randomized controlled trial, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and C-reactive protein (hs-CRP) were assayed in 163 older adults (37% males, 24% African American, BMI 34±3, age 70±5yrs) with hypertension, dyslipidemia and/or diabetes. Physical function was assessed by sixminute walk test (6MWT), chair sit-and-reach (CSR), hand-grip and knee-extension strength; specific-strength as muscle strength/mass ratio. Analyses included ANCOVA and multiple linear regression adjusted for thigh skeletal muscle (MRI), arm lean mass (DXA) and moderate-to-vigorous intensity physical activity (MVPA; accelerometry).
Results
Higher hs-CRP (p<0.01) and IL-6 (p=0.07) were associated with lower 6MWT and CSR, respectively. A composite inflammation score combining all 3 inflammatory markers showed the strongest inverse association with 6MWT (p<0.01). MVPA moderated associations such that amongst participants who engaged in low MVPA, 6MWT distances and CSR scores were significantly lower in those with high IL-6 and TNFα (p<0.05), respectively. In participants with high MVPA, higher hs-CRP (p<0.05) and TNFα (p=0.07) were associated with poorer upper-extremity specific-strength.
Conclusions
Chronic inflammation was associated with poorer physical function and specific strength in older adults with obesity and increased cardiometabolic risk. This association was strongest in participants with multiple elevated inflammatory markers. Physical activity levels below current recommendations mitigated the deleterious effects of inflammation on lower body mobility, underscoring the benefits of exercise for preserving physical function with age.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-019-1260-4</identifier><identifier>PMID: 31781724</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>accelerometry ; Aged ; Aging ; Aging - physiology ; analysis of covariance ; blood serum ; body mass index ; C-reactive protein ; Cardiovascular disease ; Cardiovascular Diseases - etiology ; diabetes ; dual-energy X-ray absorptiometry ; elderly ; Exercise ; Female ; Geriatrics/Gerontology ; Humans ; hyperlipidemia ; hypertension ; Inflammation ; Inflammation - blood ; interleukin-6 ; magnetic resonance imaging ; Male ; males ; Medicine ; Medicine & Public Health ; Metabolic disorders ; muscle strength ; Muscle Strength - physiology ; Muscular system ; Neurosciences ; Nutrition ; nutrition risk assessment ; Obesity ; Obesity - metabolism ; Older people ; Physical Exertion - physiology ; Physical fitness ; Primary Care Medicine ; Quality of Life Research ; Quantitative analysis ; randomized clinical trials ; regression analysis ; skeletal muscle ; tumor necrosis factor-alpha</subject><ispartof>The Journal of nutrition, health & aging, 2019-12, Vol.23 (10), p.949-957</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2019</rights><rights>The journal of nutrition, health & aging is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-fc8fa36638a3823d6cfde3cea228e3c6306088c2cb2b9da3cd19cb959d964d533</citedby><cites>FETCH-LOGICAL-c503t-fc8fa36638a3823d6cfde3cea228e3c6306088c2cb2b9da3cd19cb959d964d533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-019-1260-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-019-1260-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31781724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tay, Jeannie</creatorcontrib><creatorcontrib>Goss, A. M.</creatorcontrib><creatorcontrib>Locher, J. L.</creatorcontrib><creatorcontrib>Ard, J. D.</creatorcontrib><creatorcontrib>Gower, B. A.</creatorcontrib><title>Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Background
Inflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk.
Design
In baseline assessments from the CROSSROADS randomized controlled trial, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and C-reactive protein (hs-CRP) were assayed in 163 older adults (37% males, 24% African American, BMI 34±3, age 70±5yrs) with hypertension, dyslipidemia and/or diabetes. Physical function was assessed by sixminute walk test (6MWT), chair sit-and-reach (CSR), hand-grip and knee-extension strength; specific-strength as muscle strength/mass ratio. Analyses included ANCOVA and multiple linear regression adjusted for thigh skeletal muscle (MRI), arm lean mass (DXA) and moderate-to-vigorous intensity physical activity (MVPA; accelerometry).
Results
Higher hs-CRP (p<0.01) and IL-6 (p=0.07) were associated with lower 6MWT and CSR, respectively. A composite inflammation score combining all 3 inflammatory markers showed the strongest inverse association with 6MWT (p<0.01). MVPA moderated associations such that amongst participants who engaged in low MVPA, 6MWT distances and CSR scores were significantly lower in those with high IL-6 and TNFα (p<0.05), respectively. In participants with high MVPA, higher hs-CRP (p<0.05) and TNFα (p=0.07) were associated with poorer upper-extremity specific-strength.
Conclusions
Chronic inflammation was associated with poorer physical function and specific strength in older adults with obesity and increased cardiometabolic risk. This association was strongest in participants with multiple elevated inflammatory markers. Physical activity levels below current recommendations mitigated the deleterious effects of inflammation on lower body mobility, underscoring the benefits of exercise for preserving physical function with age.</description><subject>accelerometry</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>analysis of covariance</subject><subject>blood serum</subject><subject>body mass index</subject><subject>C-reactive protein</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - etiology</subject><subject>diabetes</subject><subject>dual-energy X-ray absorptiometry</subject><subject>elderly</subject><subject>Exercise</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>hypertension</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>interleukin-6</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>muscle strength</subject><subject>Muscle Strength - physiology</subject><subject>Muscular system</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>nutrition risk assessment</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Older people</subject><subject>Physical Exertion - physiology</subject><subject>Physical fitness</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>Quantitative analysis</subject><subject>randomized clinical trials</subject><subject>regression analysis</subject><subject>skeletal muscle</subject><subject>tumor necrosis factor-alpha</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkkuPFCEUhStG4zz0B7gxJG7clPKo4rExmXScsZNJ2oy6JhRQ3YwUjEBp2l8vPTWOj8S44pDz3QNcbtM8Q_AVgpC9zghTSFqIRHtQbfegOUbsIBjnD6vGTLSMQXbUnOR8DWHXC04fN0cEMY4Y7o6b7-93--y08uB8Drq4GIAKBnwoyYZt2QEXwJX16tYoEazD6NU0LfvqbbyxCZyZ2ZcMvrlasBlsdmV_m7IOOlmVrQErlYyLky1qiN5pcOXy5yfNo1H5bJ_erafNp_O3H1fv2svNxXp1dtnqHpLSjpqPilBKuCIcE0P1aCzRVmHM60oJpJBzjfWAB2EU0QYJPYheGEE70xNy2rxZcm_mYbJG21CS8vImuUmlvYzKyT-d4HZyG79KKmqCQDXg5V1Ail9mm4ucXNbWexVsnLPEXe0sp30n_o8SDAnreQcr-uIv9DrOKdROSIwF73smKK8UWiidYs7Jjvf3RlAehkAuQyDrEMiDkl2tef77g-8rfv56BfAC5GqFrU2_jv536g-qt76N</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Tay, Jeannie</creator><creator>Goss, A. M.</creator><creator>Locher, J. L.</creator><creator>Ard, J. D.</creator><creator>Gower, B. A.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20191201</creationdate><title>Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk</title><author>Tay, Jeannie ; Goss, A. M. ; Locher, J. L. ; Ard, J. D. ; Gower, B. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-fc8fa36638a3823d6cfde3cea228e3c6306088c2cb2b9da3cd19cb959d964d533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>accelerometry</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>analysis of covariance</topic><topic>blood serum</topic><topic>body mass index</topic><topic>C-reactive protein</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - etiology</topic><topic>diabetes</topic><topic>dual-energy X-ray absorptiometry</topic><topic>elderly</topic><topic>Exercise</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>hypertension</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>interleukin-6</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>muscle strength</topic><topic>Muscle Strength - physiology</topic><topic>Muscular system</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>nutrition risk assessment</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Older people</topic><topic>Physical Exertion - physiology</topic><topic>Physical fitness</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Quantitative analysis</topic><topic>randomized clinical trials</topic><topic>regression analysis</topic><topic>skeletal muscle</topic><topic>tumor necrosis factor-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tay, Jeannie</creatorcontrib><creatorcontrib>Goss, A. M.</creatorcontrib><creatorcontrib>Locher, J. L.</creatorcontrib><creatorcontrib>Ard, J. D.</creatorcontrib><creatorcontrib>Gower, B. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tay, Jeannie</au><au>Goss, A. M.</au><au>Locher, J. L.</au><au>Ard, J. D.</au><au>Gower, B. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>23</volume><issue>10</issue><spage>949</spage><epage>957</epage><pages>949-957</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Background
Inflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk.
Design
In baseline assessments from the CROSSROADS randomized controlled trial, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and C-reactive protein (hs-CRP) were assayed in 163 older adults (37% males, 24% African American, BMI 34±3, age 70±5yrs) with hypertension, dyslipidemia and/or diabetes. Physical function was assessed by sixminute walk test (6MWT), chair sit-and-reach (CSR), hand-grip and knee-extension strength; specific-strength as muscle strength/mass ratio. Analyses included ANCOVA and multiple linear regression adjusted for thigh skeletal muscle (MRI), arm lean mass (DXA) and moderate-to-vigorous intensity physical activity (MVPA; accelerometry).
Results
Higher hs-CRP (p<0.01) and IL-6 (p=0.07) were associated with lower 6MWT and CSR, respectively. A composite inflammation score combining all 3 inflammatory markers showed the strongest inverse association with 6MWT (p<0.01). MVPA moderated associations such that amongst participants who engaged in low MVPA, 6MWT distances and CSR scores were significantly lower in those with high IL-6 and TNFα (p<0.05), respectively. In participants with high MVPA, higher hs-CRP (p<0.05) and TNFα (p=0.07) were associated with poorer upper-extremity specific-strength.
Conclusions
Chronic inflammation was associated with poorer physical function and specific strength in older adults with obesity and increased cardiometabolic risk. This association was strongest in participants with multiple elevated inflammatory markers. Physical activity levels below current recommendations mitigated the deleterious effects of inflammation on lower body mobility, underscoring the benefits of exercise for preserving physical function with age.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>31781724</pmid><doi>10.1007/s12603-019-1260-4</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2019-12, Vol.23 (10), p.949-957 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6996491 |
| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | accelerometry Aged Aging Aging - physiology analysis of covariance blood serum body mass index C-reactive protein Cardiovascular disease Cardiovascular Diseases - etiology diabetes dual-energy X-ray absorptiometry elderly Exercise Female Geriatrics/Gerontology Humans hyperlipidemia hypertension Inflammation Inflammation - blood interleukin-6 magnetic resonance imaging Male males Medicine Medicine & Public Health Metabolic disorders muscle strength Muscle Strength - physiology Muscular system Neurosciences Nutrition nutrition risk assessment Obesity Obesity - metabolism Older people Physical Exertion - physiology Physical fitness Primary Care Medicine Quality of Life Research Quantitative analysis randomized clinical trials regression analysis skeletal muscle tumor necrosis factor-alpha |
| title | Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A20%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physical%20Function%20and%20Strength%20in%20Relation%20to%20Inflammation%20in%20Older%20Adults%20with%20Obesity%20and%20Increased%20Cardiometabolic%20Risk&rft.jtitle=The%20Journal%20of%20nutrition,%20health%20&%20aging&rft.au=Tay,%20Jeannie&rft.date=2019-12-01&rft.volume=23&rft.issue=10&rft.spage=949&rft.epage=957&rft.pages=949-957&rft.issn=1279-7707&rft.eissn=1760-4788&rft_id=info:doi/10.1007/s12603-019-1260-4&rft_dat=%3Cproquest_pubme%3E2400486549%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2298557968&rft_id=info:pmid/31781724&rfr_iscdi=true |