Functional Regeneration of the Sensory Root via Axonal Invasion

Regeneration following spinal root avulsion is broadly unsuccessful despite the regenerative capacity of other PNS-located nerves. By combining focal laser lesioning to model root avulsion in zebrafish, time-lapse imaging, and transgenesis, we identify that regenerating DRG neurons fail to recapitul...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-01, Vol.30 (1), p.9-17.e3
Hauptverfasser:	Nichols, Ev L., Smith, Cody J.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - metabolism Animals Axons - physiology behavior Behavior, Animal - drug effects Cell Biology DREZ DRG Ganglia, Spinal - physiopathology invasion Life Sciences & Biomedicine Nerve Regeneration - physiology OBPI Paclitaxel - pharmacology regeneration Science & Technology Sensory Receptor Cells - physiology spinal cord Spinal Cord - physiopathology Spinal Cord Injuries - physiopathology Zebrafish
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