Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model

•Mitochondrial oxidative phosphorylation is impaired in TALLYHO/Jng mice.•Expression and activities of complex I and IV are diminished in TALLYHO/Jng mice.•Impaired mitochondrial protein synthesis is one of the contributing factors.•Mitochondrial sequence variants may contribute to mitochondrial bio...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2019-11, Vol.116, p.105616-105616, Article 105616
Hauptverfasser:	Hunter, Caroline A., Kartal, Funda, Koc, Zeynep C., Murphy, Tamara, Kim, Jung Han, Denvir, James, Koc, Emine C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism animal models Animals biogenesis Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Disease Models, Animal Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Electron Transport Complex II - genetics Electron Transport Complex II - metabolism Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism enzyme activity enzymes Gene Expression Regulation Humans Insulin - metabolism Insulin Resistance Kidney - metabolism Kidney - pathology kidneys liver Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial biogenesis Mitochondrial ribosomal proteins noninsulin-dependent diabetes mellitus obesity Obesity - genetics Obesity - metabolism Obesity - pathology Oxidative Phosphorylation phenotype prognosis protein synthesis ribosomal proteins Ribosomal Proteins - genetics Ribosomal Proteins - metabolism sequence analysis TALLYHO/Jng mice transfer RNA translation (genetics) Type 2 diabetes
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