Bioresponsive microspheres for on‐demand delivery of anti‐inflammatory cytokines for articular cartilage repair

Despite innovations in surgical interventions, treatment of cartilage injury in osteoarthritic joints remains a challenge due to concomitant inflammation. Obstructing a single dominant inflammatory cytokine has shown remarkable clinical benefits in rheumatoid arthritis, and similar strategies are be...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2020-03, Vol.108 (3), p.722-733
Hauptverfasser:	Park, Eunjae, Hart, Melanie L., Rolauffs, Bernd, Stegemann, Jan P., T. Annamalai, Ramkumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Arthritis Biocompatible Materials - chemistry Biomedical materials Blocking Cartilage Cartilage (articular) Cartilage diseases Cell Line Chondrocytes Collagen Collagenase controlled drug release Controlled release Crosslinking Cytokines Cytokines - administration & dosage Cytokines - pharmacokinetics Degradation Delayed-Action Preparations - chemistry Drug delivery systems Drug Liberation Gelatin Gelatin - chemistry Humans IL‐10 IL‐13 IL‐4 Inflammation Joint diseases Medical innovations Mice Microspheres Nitric oxide Osteoarthritis Osteoarthritis - drug therapy Preservation Proteolysis Proteolytic enzymes Repair Rheumatoid arthritis
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