Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome
Background This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. Methods A total of 163 patients were randomized into two groups:...
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| Veröffentlicht in: | Digestive diseases and sciences 2020-02, Vol.65 (2), p.541-549 |
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| creator | Bahrudin, Mohd Fyzal Abdul Rani, Rafiz Tamil, Azmi Mohd Mokhtar, Norfilza Mohd Raja Ali, Raja Affendi |
| description | Background
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing
Lactobacillus helveticus
will confer benefits to constipation-predominant irritable bowel syndrome patients.
Methods
A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified
Garrigues
questionnaires for pre- and post-consumption were assessed.
Results
Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (
p |
| doi_str_mv | 10.1007/s10620-019-05695-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6995448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712935430</galeid><sourcerecordid>A712935430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-ac1478e357434e628eacd6ae8b372e5420b346008ef063007504ae63515aff103</originalsourceid><addsrcrecordid>eNqNkt9u0zAUxiMEYmPwAlwgS9wgoQz_T3KDVMqASZWoNLi2HPek80jsznZbjafiEXHW0jGEEMpFjpzf-fL5nK8onhN8SjCu3kSCJcUlJk2JhWxEyR4Ux0RUrKRC1g-LY0xkrgmRR8WTGK8wxk1F5OPiiBGaS4qPix9nXQcm2Q04iBH5Dl0kCLa332GBLm6G1vpkDXofrPuGpt4lbZ11SzTTJvlWG9v364guod9A5nI59cNKB932gJJH8-D3CpPeO0DWoblOFlyKaGvT5SgZk13lM-_KeYCFH6zTLqHzEGy6lXnnt9BnL24R_ABPi0ed7iM8279Piq8fzr5MP5Wzzx_Pp5NZaQQnqdSG8KoGJirOOEhagzYLqaFuWUVBcIpbxiXGNXRYsjxNgbkGyQQRuusIZifF253uat0OsDDZctC9WgU76HCjvLbq_hdnL9XSb5RsGsF5nQVe7QWCv15DTGqw0UDfawd-HRWlnNYkL2dEX_6BXvl1cPl6I0VqxjBhd9RS96Cs63z-rxlF1aQitGGCs9H36V-o_CxgsCbvoLP5_F4D3TWY4GMM0B3uSLAac6Z2OVM5Z-o2Z2r08uL36RxafgUrA_UO2ELru2jyyg0csJxEQYhoOM8VldO86TEAU792Kbe-_v_WTLMdHTPhlhDuZvcP_z8BSF4BVg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2241833013</pqid></control><display><type>article</type><title>Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bahrudin, Mohd Fyzal ; Abdul Rani, Rafiz ; Tamil, Azmi Mohd ; Mokhtar, Norfilza Mohd ; Raja Ali, Raja Affendi</creator><creatorcontrib>Bahrudin, Mohd Fyzal ; Abdul Rani, Rafiz ; Tamil, Azmi Mohd ; Mokhtar, Norfilza Mohd ; Raja Ali, Raja Affendi</creatorcontrib><description>Background
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing
Lactobacillus helveticus
will confer benefits to constipation-predominant irritable bowel syndrome patients.
Methods
A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified
Garrigues
questionnaires for pre- and post-consumption were assessed.
Results
Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (
p
< 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (
p
= 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (
p
< 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (
p
= 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (
p
= 0.308). Constipation-related symptoms were significantly improved for both groups.
Conclusions
The addition of polydextrose to sterilized probiotic containing
L. helveticus
did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing
L. helveticus
with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-019-05695-3</identifier><identifier>PMID: 31209720</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Biochemistry ; Care and treatment ; Constipation ; Constipation - physiopathology ; Constipation - therapy ; Double-Blind Method ; Feces ; Feces - chemistry ; Female ; Gastroenterology ; Gastroenterology & Hepatology ; Gastrointestinal Transit ; Glucans - therapeutic use ; Hepatology ; Humans ; Hydrogen-Ion Concentration ; Irritable bowel syndrome ; Irritable Bowel Syndrome - physiopathology ; Irritable Bowel Syndrome - therapy ; Lactobacillus helveticus ; Life Sciences & Biomedicine ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Oncology ; Original ; Original Article ; Polydextrose ; Prebiotics ; Probiotics ; Probiotics - therapeutic use ; Science & Technology ; Transplant Surgery ; Treatment Outcome ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2020-02, Vol.65 (2), p.541-549</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Digestive Diseases and Sciences is a copyright of Springer, (2019). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>22</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000511594400026</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c541t-ac1478e357434e628eacd6ae8b372e5420b346008ef063007504ae63515aff103</citedby><cites>FETCH-LOGICAL-c541t-ac1478e357434e628eacd6ae8b372e5420b346008ef063007504ae63515aff103</cites><orcidid>0000-0002-4863-100X ; 0000-0001-5834-2941</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-019-05695-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-019-05695-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31209720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahrudin, Mohd Fyzal</creatorcontrib><creatorcontrib>Abdul Rani, Rafiz</creatorcontrib><creatorcontrib>Tamil, Azmi Mohd</creatorcontrib><creatorcontrib>Mokhtar, Norfilza Mohd</creatorcontrib><creatorcontrib>Raja Ali, Raja Affendi</creatorcontrib><title>Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>DIGEST DIS SCI</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing
Lactobacillus helveticus
will confer benefits to constipation-predominant irritable bowel syndrome patients.
Methods
A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified
Garrigues
questionnaires for pre- and post-consumption were assessed.
Results
Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (
p
< 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (
p
= 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (
p
< 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (
p
= 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (
p
= 0.308). Constipation-related symptoms were significantly improved for both groups.
Conclusions
The addition of polydextrose to sterilized probiotic containing
L. helveticus
did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing
L. helveticus
with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Care and treatment</subject><subject>Constipation</subject><subject>Constipation - physiopathology</subject><subject>Constipation - therapy</subject><subject>Double-Blind Method</subject><subject>Feces</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology & Hepatology</subject><subject>Gastrointestinal Transit</subject><subject>Glucans - therapeutic use</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - physiopathology</subject><subject>Irritable Bowel Syndrome - therapy</subject><subject>Lactobacillus helveticus</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Polydextrose</subject><subject>Prebiotics</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Science & Technology</subject><subject>Transplant Surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkt9u0zAUxiMEYmPwAlwgS9wgoQz_T3KDVMqASZWoNLi2HPek80jsznZbjafiEXHW0jGEEMpFjpzf-fL5nK8onhN8SjCu3kSCJcUlJk2JhWxEyR4Ux0RUrKRC1g-LY0xkrgmRR8WTGK8wxk1F5OPiiBGaS4qPix9nXQcm2Q04iBH5Dl0kCLa332GBLm6G1vpkDXofrPuGpt4lbZ11SzTTJvlWG9v364guod9A5nI59cNKB932gJJH8-D3CpPeO0DWoblOFlyKaGvT5SgZk13lM-_KeYCFH6zTLqHzEGy6lXnnt9BnL24R_ABPi0ed7iM8279Piq8fzr5MP5Wzzx_Pp5NZaQQnqdSG8KoGJirOOEhagzYLqaFuWUVBcIpbxiXGNXRYsjxNgbkGyQQRuusIZifF253uat0OsDDZctC9WgU76HCjvLbq_hdnL9XSb5RsGsF5nQVe7QWCv15DTGqw0UDfawd-HRWlnNYkL2dEX_6BXvl1cPl6I0VqxjBhd9RS96Cs63z-rxlF1aQitGGCs9H36V-o_CxgsCbvoLP5_F4D3TWY4GMM0B3uSLAac6Z2OVM5Z-o2Z2r08uL36RxafgUrA_UO2ELru2jyyg0csJxEQYhoOM8VldO86TEAU792Kbe-_v_WTLMdHTPhlhDuZvcP_z8BSF4BVg</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Bahrudin, Mohd Fyzal</creator><creator>Abdul Rani, Rafiz</creator><creator>Tamil, Azmi Mohd</creator><creator>Mokhtar, Norfilza Mohd</creator><creator>Raja Ali, Raja Affendi</creator><general>Springer US</general><general>Springer Nature</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4863-100X</orcidid><orcidid>https://orcid.org/0000-0001-5834-2941</orcidid></search><sort><creationdate>20200201</creationdate><title>Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome</title><author>Bahrudin, Mohd Fyzal ; Abdul Rani, Rafiz ; Tamil, Azmi Mohd ; Mokhtar, Norfilza Mohd ; Raja Ali, Raja Affendi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-ac1478e357434e628eacd6ae8b372e5420b346008ef063007504ae63515aff103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Care and treatment</topic><topic>Constipation</topic><topic>Constipation - physiopathology</topic><topic>Constipation - therapy</topic><topic>Double-Blind Method</topic><topic>Feces</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroenterology & Hepatology</topic><topic>Gastrointestinal Transit</topic><topic>Glucans - therapeutic use</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - physiopathology</topic><topic>Irritable Bowel Syndrome - therapy</topic><topic>Lactobacillus helveticus</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Polydextrose</topic><topic>Prebiotics</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Science & Technology</topic><topic>Transplant Surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahrudin, Mohd Fyzal</creatorcontrib><creatorcontrib>Abdul Rani, Rafiz</creatorcontrib><creatorcontrib>Tamil, Azmi Mohd</creatorcontrib><creatorcontrib>Mokhtar, Norfilza Mohd</creatorcontrib><creatorcontrib>Raja Ali, Raja Affendi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahrudin, Mohd Fyzal</au><au>Abdul Rani, Rafiz</au><au>Tamil, Azmi Mohd</au><au>Mokhtar, Norfilza Mohd</au><au>Raja Ali, Raja Affendi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><stitle>DIGEST DIS SCI</stitle><addtitle>Dig Dis Sci</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>65</volume><issue>2</issue><spage>541</spage><epage>549</epage><pages>541-549</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing
Lactobacillus helveticus
will confer benefits to constipation-predominant irritable bowel syndrome patients.
Methods
A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified
Garrigues
questionnaires for pre- and post-consumption were assessed.
Results
Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (
p
< 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (
p
= 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (
p
< 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (
p
= 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (
p
= 0.308). Constipation-related symptoms were significantly improved for both groups.
Conclusions
The addition of polydextrose to sterilized probiotic containing
L. helveticus
did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing
L. helveticus
with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31209720</pmid><doi>10.1007/s10620-019-05695-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4863-100X</orcidid><orcidid>https://orcid.org/0000-0001-5834-2941</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2020-02, Vol.65 (2), p.541-549 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6995448 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Biochemistry Care and treatment Constipation Constipation - physiopathology Constipation - therapy Double-Blind Method Feces Feces - chemistry Female Gastroenterology Gastroenterology & Hepatology Gastrointestinal Transit Glucans - therapeutic use Hepatology Humans Hydrogen-Ion Concentration Irritable bowel syndrome Irritable Bowel Syndrome - physiopathology Irritable Bowel Syndrome - therapy Lactobacillus helveticus Life Sciences & Biomedicine Male Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Original Original Article Polydextrose Prebiotics Probiotics Probiotics - therapeutic use Science & Technology Transplant Surgery Treatment Outcome Young Adult |
| title | Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T22%3A00%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effectiveness%20of%20Sterilized%20Symbiotic%20Drink%20Containing%20Lactobacillus%20helveticus%20Comparable%20to%20Probiotic%20Alone%20in%20Patients%20with%20Constipation-Predominant%20Irritable%20Bowel%20Syndrome&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=Bahrudin,%20Mohd%20Fyzal&rft.date=2020-02-01&rft.volume=65&rft.issue=2&rft.spage=541&rft.epage=549&rft.pages=541-549&rft.issn=0163-2116&rft.eissn=1573-2568&rft_id=info:doi/10.1007/s10620-019-05695-3&rft_dat=%3Cgale_pubme%3EA712935430%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2241833013&rft_id=info:pmid/31209720&rft_galeid=A712935430&rfr_iscdi=true |