Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections?
Chlorhexidine mouthrinses are considered a gold standard as an adjunct treatment of oral infections. However, owing to its toxicity, discoloration of tooth surface and the emerging prevalence of drug-resistant species, attention is being given to exploring natural alternatives to the drug. The exper...
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| Veröffentlicht in: | Pakistan journal of medical sciences 2020-01, Vol.36 (2), p.271-275 |
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| creator | Fahim, Ayesha Himratul-Aznita, Wan Harun Abdul-Rahman, Puteri Shafinaz |
| description | Chlorhexidine mouthrinses are considered a gold standard as an adjunct treatment of oral infections. However, owing to its toxicity, discoloration of tooth surface and the emerging prevalence of drug-resistant species, attention is being given to exploring natural alternatives to the drug.
The experiment was carried out in Azra Naheed Center for Research and Development (ANCRD), Superior University, Lahore, Pakistan from September 2018 till May 2019. Biofilms and planktonic cells of
alone and in combination with streptococci were subjected to chlorhexidine,
and
individually and to
-
combination. Kirby-Bauer test, antifungal susceptibility testing, CFU count and drug synergy assessment was done on planktonic cells. Dynamic biofilms were formed to mimic conditions similar to oral cavity and CFU was determined.
MIC of all three agents was higher against mixed species when compared to single species planktonic cells and biofilm.
and
demonstrated synergistic effects. The decrease in CFU count and minimum biofilm reduction to salivary pellicle caused by
was comparable to that of chlorhexidine.
Thus,
-
combination demonstrated antimicrobial effects similar to chlorhexidine against planktonic cells and dynamic biofilm. It could serve as a possible natural, economical alternative to chlorhexidine mouthrinses usually recommended in dental clinics. However,
studies are required to determine the correct dosage of these agents. |
| doi_str_mv | 10.12669/pjms.36.2.1457 |
| format | Article |
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The experiment was carried out in Azra Naheed Center for Research and Development (ANCRD), Superior University, Lahore, Pakistan from September 2018 till May 2019. Biofilms and planktonic cells of
alone and in combination with streptococci were subjected to chlorhexidine,
and
individually and to
-
combination. Kirby-Bauer test, antifungal susceptibility testing, CFU count and drug synergy assessment was done on planktonic cells. Dynamic biofilms were formed to mimic conditions similar to oral cavity and CFU was determined.
MIC of all three agents was higher against mixed species when compared to single species planktonic cells and biofilm.
and
demonstrated synergistic effects. The decrease in CFU count and minimum biofilm reduction to salivary pellicle caused by
was comparable to that of chlorhexidine.
Thus,
-
combination demonstrated antimicrobial effects similar to chlorhexidine against planktonic cells and dynamic biofilm. It could serve as a possible natural, economical alternative to chlorhexidine mouthrinses usually recommended in dental clinics. However,
studies are required to determine the correct dosage of these agents.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.36.2.1457</identifier><identifier>PMID: 32063973</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Anopheles ; Antifungal agents ; Antimicrobial agents ; Bacteria ; Biofilms ; Care and treatment ; Chlorhexidine ; Drug dosages ; Drug resistance ; Experiments ; Genes ; Health aspects ; Infection ; Infections ; Microbial drug resistance ; Microorganisms ; Original ; Pharmaceutical industry ; R&D ; Research & development ; Toxicity</subject><ispartof>Pakistan journal of medical sciences, 2020-01, Vol.36 (2), p.271-275</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2020 Knowledge Bylanes</rights><rights>(c)2020 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-68f303acd589bede0a0155bfd63d9e737aa25a6bd621e78ee1cfcf2bfd2fdcb93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994870/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994870/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32063973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fahim, Ayesha</creatorcontrib><creatorcontrib>Himratul-Aznita, Wan Harun</creatorcontrib><creatorcontrib>Abdul-Rahman, Puteri Shafinaz</creatorcontrib><title>Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections?</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>Chlorhexidine mouthrinses are considered a gold standard as an adjunct treatment of oral infections. However, owing to its toxicity, discoloration of tooth surface and the emerging prevalence of drug-resistant species, attention is being given to exploring natural alternatives to the drug.
The experiment was carried out in Azra Naheed Center for Research and Development (ANCRD), Superior University, Lahore, Pakistan from September 2018 till May 2019. Biofilms and planktonic cells of
alone and in combination with streptococci were subjected to chlorhexidine,
and
individually and to
-
combination. Kirby-Bauer test, antifungal susceptibility testing, CFU count and drug synergy assessment was done on planktonic cells. Dynamic biofilms were formed to mimic conditions similar to oral cavity and CFU was determined.
MIC of all three agents was higher against mixed species when compared to single species planktonic cells and biofilm.
and
demonstrated synergistic effects. The decrease in CFU count and minimum biofilm reduction to salivary pellicle caused by
was comparable to that of chlorhexidine.
Thus,
-
combination demonstrated antimicrobial effects similar to chlorhexidine against planktonic cells and dynamic biofilm. It could serve as a possible natural, economical alternative to chlorhexidine mouthrinses usually recommended in dental clinics. However,
studies are required to determine the correct dosage of these agents.</description><subject>Anopheles</subject><subject>Antifungal agents</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Care and treatment</subject><subject>Chlorhexidine</subject><subject>Drug dosages</subject><subject>Drug resistance</subject><subject>Experiments</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Infections</subject><subject>Microbial drug resistance</subject><subject>Microorganisms</subject><subject>Original</subject><subject>Pharmaceutical industry</subject><subject>R&D</subject><subject>Research & development</subject><subject>Toxicity</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkktr3DAUhU1paR7tursiKIRs7OhhyXYXLcPQRyDQTQvZCVm6ijWVrallD-m_rzxJ00woWkjc-90jcXSy7A3BBaFCNBfbTR8LJgpakJJXz7JjImqSV4RfP9-faY5peX2UncS4wbgUJacvsyNGsWBNxY4zWHnv5j6PanK7uUdqMKhVP2fdueCRDn3rhtQKw3u0Quk0j8oj5ScYl_IO0BTQuvNh7ODWGTcAsmFEYaHcYEEvo_Hjq-yFVT7C6_v9NPvx-dP39df86tuXy_XqKtdlVU-5qC3DTGnD66YFA1hhwnlrjWCmgYpVSlGuRGsEJVDVAERbbWkCqDW6bdhp9uFOdzu3PRgNw5ReIrej69X4Wwbl5GFncJ28CTspmqasK5wEzu8FxvBrhjjJ3kUN3qsBwhwlZVwI3FC6oO-eoJswJ1f8QtW8obzC5B91ozzIZElI9-pFVK4EYTXh9V6r-A-VloHe6TCAdal-MHD2aKCD9CNdDH7e230IXtyBegwxjmAfzCBY7iMklwhJJiSVS4TSxNvHHj7wfzPD_gCokcQI</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Fahim, Ayesha</creator><creator>Himratul-Aznita, Wan Harun</creator><creator>Abdul-Rahman, Puteri Shafinaz</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections?</title><author>Fahim, Ayesha ; Himratul-Aznita, Wan Harun ; Abdul-Rahman, Puteri Shafinaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-68f303acd589bede0a0155bfd63d9e737aa25a6bd621e78ee1cfcf2bfd2fdcb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anopheles</topic><topic>Antifungal agents</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Care and treatment</topic><topic>Chlorhexidine</topic><topic>Drug dosages</topic><topic>Drug resistance</topic><topic>Experiments</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Infections</topic><topic>Microbial drug resistance</topic><topic>Microorganisms</topic><topic>Original</topic><topic>Pharmaceutical industry</topic><topic>R&D</topic><topic>Research & development</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fahim, Ayesha</creatorcontrib><creatorcontrib>Himratul-Aznita, Wan Harun</creatorcontrib><creatorcontrib>Abdul-Rahman, Puteri Shafinaz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fahim, Ayesha</au><au>Himratul-Aznita, Wan Harun</au><au>Abdul-Rahman, Puteri Shafinaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections?</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>36</volume><issue>2</issue><spage>271</spage><epage>275</epage><pages>271-275</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>Chlorhexidine mouthrinses are considered a gold standard as an adjunct treatment of oral infections. However, owing to its toxicity, discoloration of tooth surface and the emerging prevalence of drug-resistant species, attention is being given to exploring natural alternatives to the drug.
The experiment was carried out in Azra Naheed Center for Research and Development (ANCRD), Superior University, Lahore, Pakistan from September 2018 till May 2019. Biofilms and planktonic cells of
alone and in combination with streptococci were subjected to chlorhexidine,
and
individually and to
-
combination. Kirby-Bauer test, antifungal susceptibility testing, CFU count and drug synergy assessment was done on planktonic cells. Dynamic biofilms were formed to mimic conditions similar to oral cavity and CFU was determined.
MIC of all three agents was higher against mixed species when compared to single species planktonic cells and biofilm.
and
demonstrated synergistic effects. The decrease in CFU count and minimum biofilm reduction to salivary pellicle caused by
was comparable to that of chlorhexidine.
Thus,
-
combination demonstrated antimicrobial effects similar to chlorhexidine against planktonic cells and dynamic biofilm. It could serve as a possible natural, economical alternative to chlorhexidine mouthrinses usually recommended in dental clinics. However,
studies are required to determine the correct dosage of these agents.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>32063973</pmid><doi>10.12669/pjms.36.2.1457</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Anopheles Antifungal agents Antimicrobial agents Bacteria Biofilms Care and treatment Chlorhexidine Drug dosages Drug resistance Experiments Genes Health aspects Infection Infections Microbial drug resistance Microorganisms Original Pharmaceutical industry R&D Research & development Toxicity |
| title | Allium-sativum and bakuchiol combination: A natural alternative to Chlorhexidine for oral infections? |
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