Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma

EGFR-mutated lung adenocarcinoma patients treated with gefitinib and osimertinib show a therapeutic benefit limited by the appearance of secondary mutations, such as EGFRT790M and EGFRC797S. It is generally assumed that these secondary mutations render EGFR completely unresponsive to the inhibitors,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2020-02, Vol.130 (2), p.612-624
Hauptverfasser:	Bousquet Mur, Emilie, Bernardo, Sara, Papon, Laura, Mancini, Maicol, Fabbrizio, Eric, Goussard, Marion, Ferrer, Irene, Giry, Anais, Quantin, Xavier, Pujol, Jean-Louis, Calvayrac, Olivier, Moll, Herwig P, Glasson, Yaël, Pirot, Nelly, Turtoi, Andrei, Cañamero, Marta, Wong, Kwok-Kin, Yarden, Yosef, Casanova, Emilio, Soria, Jean-Charles, Colinge, Jacques, Siebel, Christian W, Mazieres, Julien, Favre, Gilles, Paz-Ares, Luis, Maraver, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Adenocarcinoma Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Amino Acid Substitution Aniline Compounds - pharmacology Animals Antineoplastic agents Biomedical research Cancer therapies Cancer treatment Chemotherapy Development and progression Diseases Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme inhibitors Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Gefitinib Gefitinib - pharmacology Health aspects HES1 protein Kinases Life Sciences Ligands Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Transgenic Mutation Mutation, Missense Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Osimertinib Phenols (Class of compounds) Phosphorylation Protein Kinase Inhibitors - pharmacology Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Targeted cancer therapy Transcription Transcription Factor HES-1 - genetics Transcription Factor HES-1 - metabolism Transgenic animals Tumors Tyrosine Tyrosine kinase inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!