Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses

Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting cell (APC) activity. Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTLs) requires the activity of endogenous DCs, suggesting that exogenous DCs stimulate antitumo...

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Veröffentlicht in:	The Journal of clinical investigation 2020-02, Vol.130 (2), p.774-788
Hauptverfasser:	Huang, Min-Nung, Nicholson, Lowell T, Batich, Kristen A, Swartz, Adam M, Kopin, David, Wellford, Sebastian, Prabhakar, Vijay K, Woroniecka, Karolina, Nair, Smita K, Fecci, Peter E, Sampson, John H, Gunn, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Analysis Animal models Antigen-presenting cells Antigens Antitumor activity B cells Biomedical research Cancer Cancer vaccines CD8 antigen Cell adhesion Connexin 43 Cytotoxicity Dendritic cells Gap junctions Glioblastoma Glioblastomas Gliomas Health aspects Immunotherapy Lymphocytes Lymphocytes T Medical tests Monocytes Peptides Proteins Spleen T cells Tumors Vaccines
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