Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo

Wear particle‐stimulated inflammatory bone destruction and the consequent aseptic loosening remain the primary causes of artificial prosthesis failure and revision. Previous studies have demonstrated that curcumin has a protective effect on bone disorders and inflammatory diseases and can ameliorate...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-01, Vol.24 (2), p.1553-1567
Hauptverfasser:	Yang, Chao, Zhu, Kechao, Yuan, Xiangwei, Zhang, Xianlong, Qian, Yebin, Cheng, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Akt pathway AKT protein Animals Bone diseases Bone implants Bone loss Bone marrow Bone Resorption - chemically induced Bone Resorption - genetics Bone Resorption - immunology Bone surgery Cell activation Cell Death - drug effects Cell differentiation Cell Differentiation - drug effects Cell Polarity - drug effects Chemical compounds Curcumin Curcumin - chemistry Curcumin - pharmacology Cytokines Cytokines - metabolism Flow cytometry Gene expression Immunomodulation Immunomodulation - drug effects immunomodulatory Inflammatory diseases Kinases Loosening Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Models, Biological Nanoparticles Nanoparticles - toxicity NF-kappa B - metabolism NF‐κB pathway Original Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects Osteogenesis - genetics Osteolysis Osteolysis - complications Osteolysis - pathology Particulate matter Phosphorylation - drug effects Polarization Polymethylmethacrylate Protective Agents - pharmacology Proto-Oncogene Proteins c-akt - metabolism RANK Ligand - pharmacology RAW 264.7 Cells Signal transduction Signal Transduction - drug effects Stains & staining Titanium Titanium - toxicity TRANCE protein Up-Regulation - drug effects Wear particles
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