How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements
Prior developmental functional magnetic resonance imaging (fMRI) studies have demonstrated elevated activation patterns in the amygdala and prefrontal cortex (PFC) in response to viewing emotional faces. As adolescence is a time of substantial variability in mood and emotional responsiveness, the st...
Gespeichert in:
| Veröffentlicht in: | Developmental cognitive neuroscience 2013-04, Vol.4, p.65-76 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 76 |
|---|---|
| container_issue | |
| container_start_page | 65 |
| container_title | Developmental cognitive neuroscience |
| container_volume | 4 |
| creator | van den Bulk, Bianca G Koolschijn, P Cédric M P Meens, Paul H F van Lang, Natasja D J van der Wee, Nic J A Rombouts, Serge A R B Vermeiren, Robert R J M Crone, Eveline A |
| description | Prior developmental functional magnetic resonance imaging (fMRI) studies have demonstrated elevated activation patterns in the amygdala and prefrontal cortex (PFC) in response to viewing emotional faces. As adolescence is a time of substantial variability in mood and emotional responsiveness, the stability of activation patterns could be fluctuating over time. In the current study, 27 healthy adolescents (age: 12-19 years) were scanned three times over a period of six months (mean test-retest interval of three months; final samples N=27, N=22, N=18). At each session, participants performed the same emotional faces task. At first measurement the presentation of emotional faces resulted in heightened activation in bilateral amygdala, bilateral lateral PFC and visual areas including the fusiform face area. Average activation did not differ across test-sessions over time, indicating that at the group level activation patterns in this network do not vary significantly over time. However, using the Intraclass Correlation Coefficient (ICC), fMRI reliability demonstrated only fair reliability for PFC (ICC=0.41-0.59) and poor reliability for the amygdala (ICC |
| doi_str_mv | 10.1016/j.dcn.2012.09.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6987697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1317404172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-b7813de8a5dea0882c1d66d4ffba5929764eefd4215ee174b0cad0bf96b1e94c3</originalsourceid><addsrcrecordid>eNpVkctuFDEQRS1ERKIkH5AN8pLNdPya7vYGFEVAkCKxIWur2q6eeNRtD7Y7MB_BP-PJS-CNLfnWuVV1CbngrOGMt5fbxtnQCMZFw3TD2PoNOeF916-0ZN3bl7fQ8pic57xl9UjdCiXekWMhmZKaqRPy5yb-ornAMCH1mYIt_gGKj4H6QMs9Upj3GwcTUAiO7hKOKYYCE7UxFfx9UIGLE2aLweInelVhi9vTOFKc4wFUtSNYrLXRYs4-bKpLijlXfEKkM0JeEs4YSj4jRyNMGc-f71Ny9-Xzj-ub1e33r9-ur25XVmpdVkPXc-mwh7VDYH0vLHdt69Q4DrCuI3etQhydEnyNyDs1MAuODaNuB45aWXlKPj5xd8swo6u9lwST2SU_Q9qbCN78_xP8vdnEB9Pqvmt1VwEfngEp_lwwFzP7uoJpgoBxyYbLassU70SV8ifp49B1ga82nJlDkmZrapLmkKRh2tQka837f_t7rXjJTf4FK22fZg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317404172</pqid></control><display><type>article</type><title>How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>van den Bulk, Bianca G ; Koolschijn, P Cédric M P ; Meens, Paul H F ; van Lang, Natasja D J ; van der Wee, Nic J A ; Rombouts, Serge A R B ; Vermeiren, Robert R J M ; Crone, Eveline A</creator><creatorcontrib>van den Bulk, Bianca G ; Koolschijn, P Cédric M P ; Meens, Paul H F ; van Lang, Natasja D J ; van der Wee, Nic J A ; Rombouts, Serge A R B ; Vermeiren, Robert R J M ; Crone, Eveline A</creatorcontrib><description>Prior developmental functional magnetic resonance imaging (fMRI) studies have demonstrated elevated activation patterns in the amygdala and prefrontal cortex (PFC) in response to viewing emotional faces. As adolescence is a time of substantial variability in mood and emotional responsiveness, the stability of activation patterns could be fluctuating over time. In the current study, 27 healthy adolescents (age: 12-19 years) were scanned three times over a period of six months (mean test-retest interval of three months; final samples N=27, N=22, N=18). At each session, participants performed the same emotional faces task. At first measurement the presentation of emotional faces resulted in heightened activation in bilateral amygdala, bilateral lateral PFC and visual areas including the fusiform face area. Average activation did not differ across test-sessions over time, indicating that at the group level activation patterns in this network do not vary significantly over time. However, using the Intraclass Correlation Coefficient (ICC), fMRI reliability demonstrated only fair reliability for PFC (ICC=0.41-0.59) and poor reliability for the amygdala (ICC<0.4). These findings suggest substantial variability of brain activity over time and may have implications for studies investigating the influence of treatment effects on changes in neural levels in adolescents with psychiatric disorders.</description><identifier>ISSN: 1878-9293</identifier><identifier>EISSN: 1878-9307</identifier><identifier>DOI: 10.1016/j.dcn.2012.09.005</identifier><identifier>PMID: 23043904</identifier><language>eng</language><publisher>Netherlands: Elsevier</publisher><subject>Adolescent ; Amygdala - physiology ; Child ; Emotions - physiology ; Facial Expression ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging - methods ; Male ; Original Research ; Pattern Recognition, Visual - physiology ; Prefrontal Cortex - physiology ; Reproducibility of Results ; Young Adult</subject><ispartof>Developmental cognitive neuroscience, 2013-04, Vol.4, p.65-76</ispartof><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-b7813de8a5dea0882c1d66d4ffba5929764eefd4215ee174b0cad0bf96b1e94c3</citedby><cites>FETCH-LOGICAL-c399t-b7813de8a5dea0882c1d66d4ffba5929764eefd4215ee174b0cad0bf96b1e94c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987697/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987697/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23043904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Bulk, Bianca G</creatorcontrib><creatorcontrib>Koolschijn, P Cédric M P</creatorcontrib><creatorcontrib>Meens, Paul H F</creatorcontrib><creatorcontrib>van Lang, Natasja D J</creatorcontrib><creatorcontrib>van der Wee, Nic J A</creatorcontrib><creatorcontrib>Rombouts, Serge A R B</creatorcontrib><creatorcontrib>Vermeiren, Robert R J M</creatorcontrib><creatorcontrib>Crone, Eveline A</creatorcontrib><title>How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements</title><title>Developmental cognitive neuroscience</title><addtitle>Dev Cogn Neurosci</addtitle><description>Prior developmental functional magnetic resonance imaging (fMRI) studies have demonstrated elevated activation patterns in the amygdala and prefrontal cortex (PFC) in response to viewing emotional faces. As adolescence is a time of substantial variability in mood and emotional responsiveness, the stability of activation patterns could be fluctuating over time. In the current study, 27 healthy adolescents (age: 12-19 years) were scanned three times over a period of six months (mean test-retest interval of three months; final samples N=27, N=22, N=18). At each session, participants performed the same emotional faces task. At first measurement the presentation of emotional faces resulted in heightened activation in bilateral amygdala, bilateral lateral PFC and visual areas including the fusiform face area. Average activation did not differ across test-sessions over time, indicating that at the group level activation patterns in this network do not vary significantly over time. However, using the Intraclass Correlation Coefficient (ICC), fMRI reliability demonstrated only fair reliability for PFC (ICC=0.41-0.59) and poor reliability for the amygdala (ICC<0.4). These findings suggest substantial variability of brain activity over time and may have implications for studies investigating the influence of treatment effects on changes in neural levels in adolescents with psychiatric disorders.</description><subject>Adolescent</subject><subject>Amygdala - physiology</subject><subject>Child</subject><subject>Emotions - physiology</subject><subject>Facial Expression</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Original Research</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Prefrontal Cortex - physiology</subject><subject>Reproducibility of Results</subject><subject>Young Adult</subject><issn>1878-9293</issn><issn>1878-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctuFDEQRS1ERKIkH5AN8pLNdPya7vYGFEVAkCKxIWur2q6eeNRtD7Y7MB_BP-PJS-CNLfnWuVV1CbngrOGMt5fbxtnQCMZFw3TD2PoNOeF916-0ZN3bl7fQ8pic57xl9UjdCiXekWMhmZKaqRPy5yb-ornAMCH1mYIt_gGKj4H6QMs9Upj3GwcTUAiO7hKOKYYCE7UxFfx9UIGLE2aLweInelVhi9vTOFKc4wFUtSNYrLXRYs4-bKpLijlXfEKkM0JeEs4YSj4jRyNMGc-f71Ny9-Xzj-ub1e33r9-ur25XVmpdVkPXc-mwh7VDYH0vLHdt69Q4DrCuI3etQhydEnyNyDs1MAuODaNuB45aWXlKPj5xd8swo6u9lwST2SU_Q9qbCN78_xP8vdnEB9Pqvmt1VwEfngEp_lwwFzP7uoJpgoBxyYbLassU70SV8ifp49B1ga82nJlDkmZrapLmkKRh2tQka837f_t7rXjJTf4FK22fZg</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>van den Bulk, Bianca G</creator><creator>Koolschijn, P Cédric M P</creator><creator>Meens, Paul H F</creator><creator>van Lang, Natasja D J</creator><creator>van der Wee, Nic J A</creator><creator>Rombouts, Serge A R B</creator><creator>Vermeiren, Robert R J M</creator><creator>Crone, Eveline A</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements</title><author>van den Bulk, Bianca G ; Koolschijn, P Cédric M P ; Meens, Paul H F ; van Lang, Natasja D J ; van der Wee, Nic J A ; Rombouts, Serge A R B ; Vermeiren, Robert R J M ; Crone, Eveline A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-b7813de8a5dea0882c1d66d4ffba5929764eefd4215ee174b0cad0bf96b1e94c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Amygdala - physiology</topic><topic>Child</topic><topic>Emotions - physiology</topic><topic>Facial Expression</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Original Research</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Prefrontal Cortex - physiology</topic><topic>Reproducibility of Results</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Bulk, Bianca G</creatorcontrib><creatorcontrib>Koolschijn, P Cédric M P</creatorcontrib><creatorcontrib>Meens, Paul H F</creatorcontrib><creatorcontrib>van Lang, Natasja D J</creatorcontrib><creatorcontrib>van der Wee, Nic J A</creatorcontrib><creatorcontrib>Rombouts, Serge A R B</creatorcontrib><creatorcontrib>Vermeiren, Robert R J M</creatorcontrib><creatorcontrib>Crone, Eveline A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental cognitive neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Bulk, Bianca G</au><au>Koolschijn, P Cédric M P</au><au>Meens, Paul H F</au><au>van Lang, Natasja D J</au><au>van der Wee, Nic J A</au><au>Rombouts, Serge A R B</au><au>Vermeiren, Robert R J M</au><au>Crone, Eveline A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements</atitle><jtitle>Developmental cognitive neuroscience</jtitle><addtitle>Dev Cogn Neurosci</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>4</volume><spage>65</spage><epage>76</epage><pages>65-76</pages><issn>1878-9293</issn><eissn>1878-9307</eissn><abstract>Prior developmental functional magnetic resonance imaging (fMRI) studies have demonstrated elevated activation patterns in the amygdala and prefrontal cortex (PFC) in response to viewing emotional faces. As adolescence is a time of substantial variability in mood and emotional responsiveness, the stability of activation patterns could be fluctuating over time. In the current study, 27 healthy adolescents (age: 12-19 years) were scanned three times over a period of six months (mean test-retest interval of three months; final samples N=27, N=22, N=18). At each session, participants performed the same emotional faces task. At first measurement the presentation of emotional faces resulted in heightened activation in bilateral amygdala, bilateral lateral PFC and visual areas including the fusiform face area. Average activation did not differ across test-sessions over time, indicating that at the group level activation patterns in this network do not vary significantly over time. However, using the Intraclass Correlation Coefficient (ICC), fMRI reliability demonstrated only fair reliability for PFC (ICC=0.41-0.59) and poor reliability for the amygdala (ICC<0.4). These findings suggest substantial variability of brain activity over time and may have implications for studies investigating the influence of treatment effects on changes in neural levels in adolescents with psychiatric disorders.</abstract><cop>Netherlands</cop><pub>Elsevier</pub><pmid>23043904</pmid><doi>10.1016/j.dcn.2012.09.005</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1878-9293 |
| ispartof | Developmental cognitive neuroscience, 2013-04, Vol.4, p.65-76 |
| issn | 1878-9293 1878-9307 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6987697 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Amygdala - physiology Child Emotions - physiology Facial Expression Female Humans Longitudinal Studies Magnetic Resonance Imaging - methods Male Original Research Pattern Recognition, Visual - physiology Prefrontal Cortex - physiology Reproducibility of Results Young Adult |
| title | How stable is activation in the amygdala and prefrontal cortex in adolescence? A study of emotional face processing across three measurements |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T02%3A17%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=How%20stable%20is%20activation%20in%20the%20amygdala%20and%20prefrontal%20cortex%20in%20adolescence?%20A%20study%20of%20emotional%20face%20processing%20across%20three%20measurements&rft.jtitle=Developmental%20cognitive%20neuroscience&rft.au=van%20den%20Bulk,%20Bianca%20G&rft.date=2013-04-01&rft.volume=4&rft.spage=65&rft.epage=76&rft.pages=65-76&rft.issn=1878-9293&rft.eissn=1878-9307&rft_id=info:doi/10.1016/j.dcn.2012.09.005&rft_dat=%3Cproquest_pubme%3E1317404172%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1317404172&rft_id=info:pmid/23043904&rfr_iscdi=true |