Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea
Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate...
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| Veröffentlicht in: | Scientific reports 2020-01, Vol.10 (1), p.1306-1306, Article 1306 |
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| creator | Park, Shin Young Han, Sunmi Kim, Young-Man Kim, Jieun Lee, Sodam Yang, Jiyeon Kim, Un-Na Park, Mi-sun |
| description | Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This retrospective cohort study included 116,742 contacts identified during the investigation of 2,609 TB cases diagnosed from January to December 2015. We searched the Korean National Tuberculosis Surveillance System TB registry to identify contacts that developed active TB during follow-up until May 2018. During the mean observation period of 2.9 years, 499 of 116,742 contacts (0.4%) developed new active TB. From these contacts, 404 (81.0%) developed TB within 2 years after exposure. The 2-year Kaplan-Meier cumulative risk for TB was the highest in contacts aged ≥65 years [1%; 95% confidence interval (CI), 0.8–1.3]. Contacts with LTBI who completed chemoprophylaxis exhibited a lower risk of active TB development than those without chemoprophylaxis (adjusted hazard ratio, 0.16; 95% CI, 0.08–0.29). Aggressive contact investigation is effective for the early detection and prevention of TB in congregate settings. The risk of progression to active TB among contacts with LTBI can be minimised by the completion of chemoprophylaxis. |
| doi_str_mv | 10.1038/s41598-020-57697-1 |
| format | Article |
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This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This retrospective cohort study included 116,742 contacts identified during the investigation of 2,609 TB cases diagnosed from January to December 2015. We searched the Korean National Tuberculosis Surveillance System TB registry to identify contacts that developed active TB during follow-up until May 2018. During the mean observation period of 2.9 years, 499 of 116,742 contacts (0.4%) developed new active TB. From these contacts, 404 (81.0%) developed TB within 2 years after exposure. The 2-year Kaplan-Meier cumulative risk for TB was the highest in contacts aged ≥65 years [1%; 95% confidence interval (CI), 0.8–1.3]. Contacts with LTBI who completed chemoprophylaxis exhibited a lower risk of active TB development than those without chemoprophylaxis (adjusted hazard ratio, 0.16; 95% CI, 0.08–0.29). Aggressive contact investigation is effective for the early detection and prevention of TB in congregate settings. The risk of progression to active TB among contacts with LTBI can be minimised by the completion of chemoprophylaxis.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-57697-1</identifier><identifier>PMID: 31992740</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/255/1856 ; Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Humanities and Social Sciences ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; multidisciplinary ; Odds Ratio ; Population Surveillance ; Proportional Hazards Models ; Republic of Korea - epidemiology ; Risk Assessment ; Risk Factors ; Science ; Science (multidisciplinary) ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - transmission ; Young Adult</subject><ispartof>Scientific reports, 2020-01, Vol.10 (1), p.1306-1306, Article 1306</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-db3393cacb4f4caaf30a1ad1e3d1aef6d7d2c0523573b03384995c47a2bacf0f3</citedby><cites>FETCH-LOGICAL-c522t-db3393cacb4f4caaf30a1ad1e3d1aef6d7d2c0523573b03384995c47a2bacf0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987175/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987175/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31992740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Shin Young</creatorcontrib><creatorcontrib>Han, Sunmi</creatorcontrib><creatorcontrib>Kim, Young-Man</creatorcontrib><creatorcontrib>Kim, Jieun</creatorcontrib><creatorcontrib>Lee, Sodam</creatorcontrib><creatorcontrib>Yang, Jiyeon</creatorcontrib><creatorcontrib>Kim, Un-Na</creatorcontrib><creatorcontrib>Park, Mi-sun</creatorcontrib><title>Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This retrospective cohort study included 116,742 contacts identified during the investigation of 2,609 TB cases diagnosed from January to December 2015. We searched the Korean National Tuberculosis Surveillance System TB registry to identify contacts that developed active TB during follow-up until May 2018. During the mean observation period of 2.9 years, 499 of 116,742 contacts (0.4%) developed new active TB. From these contacts, 404 (81.0%) developed TB within 2 years after exposure. The 2-year Kaplan-Meier cumulative risk for TB was the highest in contacts aged ≥65 years [1%; 95% confidence interval (CI), 0.8–1.3]. Contacts with LTBI who completed chemoprophylaxis exhibited a lower risk of active TB development than those without chemoprophylaxis (adjusted hazard ratio, 0.16; 95% CI, 0.08–0.29). Aggressive contact investigation is effective for the early detection and prevention of TB in congregate settings. The risk of progression to active TB among contacts with LTBI can be minimised by the completion of chemoprophylaxis.</description><subject>692/499</subject><subject>692/699/255/1856</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Odds Ratio</subject><subject>Population Surveillance</subject><subject>Proportional Hazards Models</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Shin Young</au><au>Han, Sunmi</au><au>Kim, Young-Man</au><au>Kim, Jieun</au><au>Lee, Sodam</au><au>Yang, Jiyeon</au><au>Kim, Un-Na</au><au>Park, Mi-sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-01-28</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>1306</spage><epage>1306</epage><pages>1306-1306</pages><artnum>1306</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This retrospective cohort study included 116,742 contacts identified during the investigation of 2,609 TB cases diagnosed from January to December 2015. We searched the Korean National Tuberculosis Surveillance System TB registry to identify contacts that developed active TB during follow-up until May 2018. During the mean observation period of 2.9 years, 499 of 116,742 contacts (0.4%) developed new active TB. From these contacts, 404 (81.0%) developed TB within 2 years after exposure. The 2-year Kaplan-Meier cumulative risk for TB was the highest in contacts aged ≥65 years [1%; 95% confidence interval (CI), 0.8–1.3]. Contacts with LTBI who completed chemoprophylaxis exhibited a lower risk of active TB development than those without chemoprophylaxis (adjusted hazard ratio, 0.16; 95% CI, 0.08–0.29). Aggressive contact investigation is effective for the early detection and prevention of TB in congregate settings. The risk of progression to active TB among contacts with LTBI can be minimised by the completion of chemoprophylaxis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31992740</pmid><doi>10.1038/s41598-020-57697-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/699/255/1856 Adolescent Adult Aged Child Child, Preschool Female Humanities and Social Sciences Humans Incidence Infant Infant, Newborn Male Middle Aged multidisciplinary Odds Ratio Population Surveillance Proportional Hazards Models Republic of Korea - epidemiology Risk Assessment Risk Factors Science Science (multidisciplinary) Tuberculosis Tuberculosis - epidemiology Tuberculosis - transmission Young Adult |
| title | Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea |
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