Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma

L-type amino acid transporter 1 (LAT1) plays a role in transporting essential amino acids including leucine, which regulates the mTOR signaling pathway. Here, we studied the expression profile and functional role of LAT1 in bladder cancer. Furthermore, the pharmacological activity of JPH203, a speci...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.1292-1292, Article 1292
Hauptverfasser:	Maimaiti, Maihulan, Sakamoto, Shinichi, Yamada, Yasutaka, Sugiura, Masahiro, Rii, Junryo, Takeuchi, Nobuyoshi, Imamura, Yusuke, Furihata, Tomomi, Ando, Keisuke, Higuchi, Kosuke, Xu, Minhui, Sazuka, Tomokazu, Nakamura, Kazuyoshi, Kaneda, Atsushi, Kanai, Yoshikatsu, Kyprianou, Natasha, Ikehara, Yuzuru, Anzai, Naohiko, Ichikawa, Tomohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/91 59 631/67/1059/99 631/67/1680 631/67/589/1336 64 692/4025/1334 82 82/29 96/1 96/31 AKT protein Amino acids Benzoxazoles - pharmacology Bladder cancer Cell Line, Tumor Cell migration Disease-Free Survival Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Insulin Insulin-like growth factor-binding protein 5 Invasiveness Kinases Large Neutral Amino Acid-Transporter 1 - biosynthesis Leucine Male MAP kinase MAP Kinase Signaling System multidisciplinary Multivariate analysis Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Phosphorylation Ribonucleic acid RNA Science Science (multidisciplinary) Signal transduction Survival Rate TOR protein TOR Serine-Threonine Kinases - metabolism Tyrosine - analogs & derivatives Tyrosine - pharmacology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - microbiology Urinary Bladder Neoplasms - pathology
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