Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators
Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many o...
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Veröffentlicht in: | Physiology (Bethesda, Md.) Md.), 2020-01, Vol.35 (1), p.57-68 |
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description | Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies. |
doi_str_mv | 10.1152/physiol.00014.2019 |
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A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.</description><subject>Animals</subject><subject>Cough - physiopathology</subject><subject>Humans</subject><subject>Inflammation Mediators - physiology</subject><subject>Lung - physiopathology</subject><subject>Nerve Fibers, Unmyelinated - physiology</subject><subject>Reflex - physiology</subject><subject>Review</subject><subject>Vagus Nerve - physiology</subject><issn>1548-9213</issn><issn>1548-9221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLxDAUhYMovv-AC-nSTcc8mtdG0MHHgOJGXQkhSVMnkjZj0grz7-3oOOjqXrjnnHvgA-AEwQlCFJ8v5svsY5hACFE1wRDJLbCPaCVKiTHa3uyI7IGDnN8hJFRQvAv2COJSSkj3wetDDM4OQafzWey8La509rmITfGi33QorlLs7DwuhtDGTqdlMS1vvHGpuLS9_9S9j11hlsWsa4JuW93HUfLgar_a8hHYaXTI7ng9D8HzzfXT9K68f7ydTS_vS1tB3JdC1gw3xvKqNtyIhpuGCgYFktYQCBmmVhqrDWHOUimc1hXlnFXO1pxRZ8khuPjJXQymdbV1XZ90UIvk27Gyitqr_5fOz9Vb_FRMCsoFGQPO1gEpfgwu96r12boQdOfikBUmGDGGK85GKf6R2hRzTq7ZvEFQrbCoNRb1jUWtsIym078FN5ZfDuQLKoeNdg</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Undem, Bradley J</creator><creator>Sun, Hui</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators</title><author>Undem, Bradley J ; Sun, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-89d62fbc74db7b8f7bf5860819cb300625c9bcab36ec598eaa457764ecd765ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Cough - physiopathology</topic><topic>Humans</topic><topic>Inflammation Mediators - physiology</topic><topic>Lung - physiopathology</topic><topic>Nerve Fibers, Unmyelinated - physiology</topic><topic>Reflex - physiology</topic><topic>Review</topic><topic>Vagus Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Undem, Bradley J</creatorcontrib><creatorcontrib>Sun, Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiology (Bethesda, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Undem, Bradley J</au><au>Sun, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators</atitle><jtitle>Physiology (Bethesda, Md.)</jtitle><addtitle>Physiology (Bethesda)</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>35</volume><issue>1</issue><spage>57</spage><epage>68</epage><pages>57-68</pages><issn>1548-9213</issn><eissn>1548-9221</eissn><abstract>Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. 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subjects | Animals Cough - physiopathology Humans Inflammation Mediators - physiology Lung - physiopathology Nerve Fibers, Unmyelinated - physiology Reflex - physiology Review Vagus Nerve - physiology |
title | Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators |
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