Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar

Background Higher-order structure (HOS) assessment is an important component of biosimilarity evaluations. While established spectroscopic methods are routinely used to characterize structure and evaluate similarity, the addition of X-ray crystallographic analysis to these biophysical methods enable...

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Veröffentlicht in:	BioDrugs 2020-02, Vol.34 (1), p.77-87
Hauptverfasser:	Lerch, Thomas F., Sharpe, Penelope, Mayclin, Stephen J., Edwards, Thomas E., Polleck, Sharon, Rouse, Jason C., Zou, Qin, Conlon, Hugh D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological products Biomedical and Life Sciences Biomedicine Biosimilar Pharmaceuticals - chemistry Cancer Research Chromatography Complementarity Crystal structure Crystallography Data collection Enzymes European Union Fourier transforms Humans Immunotherapy Infliximab Infliximab - chemistry Life sciences Molecular Medicine Molecular structure Monoclonal antibodies NMR Nuclear magnetic resonance Original Original Research Article Pharmacotherapy Physicochemical properties Polyethylene glycol Sedimentation & deposition Self-association Sodium TNF inhibitors Tumor necrosis factor-TNF Tumor necrosis factor-α Ultracentrifugation X-rays
Online-Zugang:	Volltext
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