Recombinant human activated protein C for severe sepsis in neonates

Background Sepsis is a common problem in preterm and term infants. The incidence of neonatal sepsis has declined, but mortality remains high. Recombinant human activated protein C (rhAPC) possess a broad spectrum of activity modulating coagulation and inflammation. In septic adults it may reduce mor...

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Veröffentlicht in:	Cochrane database of systematic reviews 2012-04, Vol.2020 (1), p.CD005385
Hauptverfasser:	Kylat, Ranjit I, Ohlsson, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Anti-Infective Agents - adverse effects Anti-Infective Agents - therapeutic use Anti‐Bacterial Agents Anti‐Infective Agents Chemotherapy, Adjuvant Chemotherapy, Adjuvant - methods Child health Humans Infant, Newborn Infection Infections in newborns Infections in newborns: sepsis Infectious disease Medicine General & Introductory Medical Sciences Neonatal care Neonatal infections Neonatal infections: nosocomial sepsis Nosocomial sepsis Postnatal Bacterial Infections Protein C Protein C - adverse effects Protein C - therapeutic use Recombinant Proteins Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Safety-Based Drug Withdrawals Sepsis Sepsis - drug therapy Sepsis - mortality
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