Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation

Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin shared between ISCs and their progeny. Here, we have used a Sox9 reporter to examine chromatin across ISC differentiation. We find that open chromatin regions (OCRs) can be defined as broadly permissive...

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Veröffentlicht in:	Development (Cambridge) 2020-01, Vol.147 (1)
Hauptverfasser:	Raab, Jesse R, Tulasi, Deepthi Y, Wager, Kortney E, Morowitz, Jeremy M, Magness, Scott T, Gracz, Adam D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Chromatin - metabolism Chromatin Assembly and Disassembly DNA Methylation Gene Expression Profiling Gene Regulatory Networks Genes, Reporter Intestines - cytology Male Mice Mice, Inbred C57BL Organ Culture Techniques SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Stem Cells - metabolism Stem Cells - physiology Stem Cells and Regeneration
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