Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy

Claudins are cell-cell adhesion proteins, which are expressed in tight junctions (TJs), the most common apical cell-cell adhesion. Claudin proteins help to regulate defense and barrier functions, as well as differentiation and polarity in epithelial and endothelial cells. A series of studies have no...

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Veröffentlicht in:	International journal of molecular sciences 2019-12, Vol.21 (1), p.53
Hauptverfasser:	Gowrikumar, Saiprasad, Singh, Amar B, Dhawan, Punita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer Cell adhesion Cell growth Chemoresistance Claudins - analysis Claudins - metabolism Disease management DNA methylation Drug Resistance, Neoplasm Endothelial cells Epithelial-Mesenchymal Transition - drug effects Humans Kinases Malignancy Mesenchyme Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Ovarian cancer Phenotypes Polarity Prognosis Proteins Review Stem cells Tight junctions
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