Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells

Cancer cells are known to contain high levels of the heat shock protein 70 kDa (Hsp70), which mediates increased cell proliferation, escape from programmed cell death, enhanced invasion, and metastasis. A part of Hsp70 molecules may release from cancer cells and affect the behavior of adjacent strom...

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Veröffentlicht in:	International journal of molecular sciences 2019-12, Vol.21 (1), p.59
Hauptverfasser:	Komarova, Elena Y, Marchenko, Larisa V, Zhakhov, Alexander V, Nikotina, Alina D, Aksenov, Nikolay D, Suezov, Roman V, Ischenko, Alexander M, Margulis, Boris A, Guzhova, Irina V
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Apoptosis Arginase Carcinogenesis - immunology Carcinogenesis - pathology Cell activation Cell death Cell Line, Tumor Cell Proliferation Chromatography Coculture Techniques Cytokines Epithelial-Mesenchymal Transition Genotype & phenotype Heat shock proteins HSP70 Heat-Shock Proteins - immunology Hsp70 protein Humans Immune response Immunity Immunosuppressive agents Inflammation Macrophages Macrophages - immunology Macrophages - pathology Mesenchyme Metastases Monocytes Monocytes - immunology Monocytes - pathology Phenotypes Proteins Stromal cells Tumor cells Tumor Microenvironment Tumor necrosis factor-TNF Tumors
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