Structural characterization and in-silico analysis of Momordica charantia 7S globulin for stability and ACE inhibition

Momordica charantia ( Mc ) seeds are widely used edible crop with high nutritional quality. The food and pharmaceutical industries use it as a natural anti-oxygenic agent. Herein, a ~52 kDa protein, which is a major part of seed proteome has been purified, biochemically characterized and structure h...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.1160-1160, Article 1160
Hauptverfasser:	Kesari, Pooja, Pratap, Shivendra, Dhankhar, Poonam, Dalal, Vikram, Mishra, Manisha, Singh, Pradyumna Kumar, Chauhan, Harsh, Kumar, Pravindra
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 631/114/2410 631/535/1266 82/16 82/29 82/58 82/83 Acetates - analysis Acetic acid Amino acid sequence Angiotensin Angiotensin-Converting Enzyme Inhibitors - chemistry Angiotensin-Converting Enzyme Inhibitors - isolation & purification Angiotensin-Converting Enzyme Inhibitors - pharmacology Antihypertensives Antioxidants Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Copper - analysis Crystal structure Crystallography, X-Ray Diabetes mellitus Food Food industry Food quality Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Globulins Globulins - chemistry Globulins - isolation & purification Globulins - pharmacology Glycosylation Humanities and Social Sciences Lisinopril - pharmacology Models, Molecular Molecular Dynamics Simulation Momordica charantia Momordica charantia - chemistry multidisciplinary Nutritive value Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - drug effects Peptidyl-Dipeptidase A - metabolism Pharmaceutical industry Protein Binding Protein Conformation Protein Domains Protein folding Protein Processing, Post-Translational Protein structure Proteins Proteomes Science Science (multidisciplinary) Seed Storage Proteins - chemistry Seed Storage Proteins - isolation & purification Seed Storage Proteins - pharmacology Seeds Seeds - chemistry Sequence Alignment Sequence Homology, Amino Acid Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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