A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are characterized by increased protein aggregation in the brain, progressive neuronal loss, increased inflammation, and neurogenesis impairment. We analyzed the effects of a new purine derivative drug, PDD005, in attenuating...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.1143, Article 1143
Hauptverfasser:	Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Roux, Gwenaëlle Le, Varela, Paloma F., Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/154/436 631/154/436/1729 631/154/436/2388 631/154/555 631/378 631/378/2649 631/378/368 Aging Aging - psychology Animals Astrocytes Blood-Brain Barrier Brain - metabolism Cells, Cultured Cognition Disorders - drug therapy Cognition Disorders - prevention & control Cognitive ability Donepezil - pharmacology Drug Evaluation, Preclinical Endothelial Cells - drug effects Gene Expression Regulation - drug effects Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - biosynthesis Glycogen Synthase Kinase 3 beta - genetics Hippocampus - drug effects Humanities and Social Sciences IL-1β Interleukin-1beta - biosynthesis Interleukin-1beta - genetics Kinases Life Sciences Male Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Transgenic Microglia Mitochondria - drug effects Molecular Targeted Therapy Movement disorders multidisciplinary Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nestin Neurodegenerative diseases Neurogenesis Neurogenesis - drug effects Neuroglia - drug effects Neuronal Plasticity - drug effects Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Parkinson's disease Pathology Phosphorylation - drug effects Postsynaptic density Prohibitin Protein interaction Protein Processing, Post-Translational - drug effects Repressor Proteins - antagonists & inhibitors Repressor Proteins - biosynthesis Repressor Proteins - genetics Science Science (multidisciplinary) Synaptophysin Tau protein tau Proteins - metabolism Tauopathies - drug therapy Tauopathies - prevention & control
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