Higher Urine bis(Monoacylglycerol)Phosphate Levels in LRRK2 G2019S Mutation Carriers: Implications for Therapeutic Development

Background LRRK2 mutations are a common cause of dominantly inherited PD. Previous studies showed decreases in urine levels of didocohexaenoyl (22:6) bis(monoacylglycerol)phosphate in LRRK2‐knockout mice and in non‐human primates treated with LRRK2 kinase inhibitors. We hypothesized that urine level...

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Veröffentlicht in:	Movement disorders 2020-01, Vol.35 (1), p.134-141
Hauptverfasser:	Alcalay, Roy N., Hsieh, Frank, Tengstrand, Elizabeth, Padmanabhan, Shalini, Baptista, Marco, Kehoe, Caitlin, Narayan, Sushma, Boehme, Amelia K., Merchant, Kalpana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Clinical trials Cognitive ability Female Heterozygote Humans Isoforms Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Liquid chromatography LRRK2 protein Male Mass spectroscopy Middle Aged Movement disorders Mutation Mutation - genetics Neurodegenerative diseases Parkinson Disease - genetics Parkinson Disease - physiopathology Parkinson's disease Parkinsonian Disorders - genetics Phenotype Phenotypes Phosphate Phospholipids Urine
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