Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase

A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. We have applied physicochemical lessons from previous work to redesign and improve the antibacterial potency of pyridopyrimidine inhi...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-08, Vol.62 (16), p.7489-7505
Hauptverfasser:	Andrews, Logan D, Kane, Timothy R, Dozzo, Paola, Haglund, Cat M, Hilderbrandt, Darin J, Linsell, Martin S, Machajewski, Timothy, McEnroe, Glen, Serio, Alisa W, Wlasichuk, Kenneth B, Neau, David B, Pakhomova, Svetlana, Waldrop, Grover L, Sharp, Marc, Pogliano, Joe, Cirz, Ryan T, Cohen, Frederick
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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