Horses with equine recurrent uveitis have an activated CD4+ T‐cell phenotype that can be modulated by mesenchymal stem cells in vitro

Equine recurrent uveitis (ERU) is an immune‐mediated disease causing repeated or persistent inflammatory episodes which can lead to blindness. Currently, there is no cure for horses with this disease. Mesenchymal stem cells (MSCs) are effective at reducing immune cell activation in vitro in many spe...

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Veröffentlicht in:	Veterinary ophthalmology 2020-01, Vol.23 (1), p.160-170
Hauptverfasser:	Saldinger, Laurel K., Nelson, Seldy G., Bellone, Rebecca R., Lassaline, Mary, Mack, Maura, Walker, Naomi J., Borjesson, Dori L.
Format:	Artikel
Sprache:	eng
Schlagworte:	activated CD4+ T‐cells Animals CD4-Positive T-Lymphocytes - physiology CD8-Positive T-Lymphocytes - metabolism Cells, Cultured Coculture Techniques equine recurrent uveitis Gene Expression Regulation Horse Diseases - pathology Horses immunomodulation Interferon-gamma Interleukin-2 Receptor alpha Subunit L-Selectin - genetics L-Selectin - metabolism mesenchymal stem cells Mesenchymal Stem Cells - physiology Original Uveitis - pathology Uveitis - veterinary
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