Filaggrin null mutations and childhood atopic eczema: A population-based case-control study
Background Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. Objective We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in...
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| creator | Brown, Sara J., MRCP Relton, Caroline L., PhD Liao, Haihui, MD Zhao, Yiwei, MD Sandilands, Aileen, PhD Wilson, Ian J., PhD Burn, John, MD Reynolds, Nick J., MD McLean, W. H. Irwin, PhD, DSc Cordell, Heather J., DPhil |
| description | Background Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. Objective We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in an unselected population cohort. Methods Eight hundred eleven English children aged 7 to 9 years were screened for FLG mutations. Eczema cases were defined by using United Kingdom diagnostic criteria and skin examination. Asthma and seasonal rhinitis cases were defined by parental questionnaire. Association between phenotype and genotype was investigated using Fisher exact test and logistic regression analysis. Results The 12-month period prevalence of atopic eczema was 24.2% (95% CI, 21.2% to 27.2%), with 96% (115/120) of cases having mild-to-moderate disease. The combined null genotype (carriage of ≥1 FLG mutations) was significantly associated with atopic eczema ( P = 1.2 × 10−4 ). The odds ratio (OR) for individuals carrying 2 null mutations was 26.9 (95% CI, 3.3-217.1), but heterozygote carriers showed no significant increase in risk (OR, 1.2; 95% CI, 0.7-1.9). Eight of 190 eczema cases (4.2%) carried 2 FLG null mutations and thus might be attributed to filaggrin deficiency. Asthma in the context of eczema showed significant association with the FLG null mutations ( P = 7.1 × 10−4 ). There was no association of FLG with asthma independent of eczema ( P = .15) and no association with seasonal rhinitis ( P = .66). Conclusion FLG null mutations are significantly associated with mild-to-moderate atopic eczema in childhood, with a recessive pattern of inheritance. |
| doi_str_mv | 10.1016/j.jaci.2008.01.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6978152</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674908001437</els_id><sourcerecordid>70479693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-95a8369a871a0d3ee98ffced16189b43a7f7bd7f43a2be3ec464413987a918533</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhgdR7Fr9A17IgOjdrOckM5NEpFBKq0LBC_XKi5DNZHazZpM1mSmsv74Zd2m1Fy4c8kGe85Fz3qJ4iTBHwPbder5W2s4JAJ8DZqOPihmCYFXLSfO4mAEIrFpWi5PiWUpryHfKxdPiBDlFiqSdFT-urFPLZbS-9KNz5WYc1GCDT6XyXalX1nWrELpSDWFrdWn0b7NR78vzchu2o_uDVguVTGbzWunghxhcmYax2z0vnvTKJfPisJ8W368uv118qq6_fPx8cX5daUaaoRKN4rQVijNU0FFjBO97bTpskYtFTRXr2aJjfT6RhaFG121dIxWcKYG8ofS0ONvH3Y6Ljem0yTUoJ7fRblTcyaCs_PfF25VchhvZCsaxITnA20OAGH6NJg1yY5M2zilvwpgkg5qJVtCjIEGgKCg7DsJEkeMRUTQ1R1Zn8PUDcB3G6HNfJTZTfVkSIlNkT-kYUoqmv-sCgpxEI9dyEo2cRCMBs001vPq7f_cuB5Vk4M0BUEkr10fltU13HIEGBOFT9g97zuRp31gTZdLW-DxLG40eZBfs_-s4e-CunfU2Z_xpdibd_1cmIkF-neQ9qRs4ANa5n7e3bPSj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504791019</pqid></control><display><type>article</type><title>Filaggrin null mutations and childhood atopic eczema: A population-based case-control study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Brown, Sara J., MRCP ; Relton, Caroline L., PhD ; Liao, Haihui, MD ; Zhao, Yiwei, MD ; Sandilands, Aileen, PhD ; Wilson, Ian J., PhD ; Burn, John, MD ; Reynolds, Nick J., MD ; McLean, W. H. Irwin, PhD, DSc ; Cordell, Heather J., DPhil</creator><creatorcontrib>Brown, Sara J., MRCP ; Relton, Caroline L., PhD ; Liao, Haihui, MD ; Zhao, Yiwei, MD ; Sandilands, Aileen, PhD ; Wilson, Ian J., PhD ; Burn, John, MD ; Reynolds, Nick J., MD ; McLean, W. H. Irwin, PhD, DSc ; Cordell, Heather J., DPhil</creatorcontrib><description>Background Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. Objective We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in an unselected population cohort. Methods Eight hundred eleven English children aged 7 to 9 years were screened for FLG mutations. Eczema cases were defined by using United Kingdom diagnostic criteria and skin examination. Asthma and seasonal rhinitis cases were defined by parental questionnaire. Association between phenotype and genotype was investigated using Fisher exact test and logistic regression analysis. Results The 12-month period prevalence of atopic eczema was 24.2% (95% CI, 21.2% to 27.2%), with 96% (115/120) of cases having mild-to-moderate disease. The combined null genotype (carriage of ≥1 FLG mutations) was significantly associated with atopic eczema ( P = 1.2 × 10−4 ). The odds ratio (OR) for individuals carrying 2 null mutations was 26.9 (95% CI, 3.3-217.1), but heterozygote carriers showed no significant increase in risk (OR, 1.2; 95% CI, 0.7-1.9). Eight of 190 eczema cases (4.2%) carried 2 FLG null mutations and thus might be attributed to filaggrin deficiency. Asthma in the context of eczema showed significant association with the FLG null mutations ( P = 7.1 × 10−4 ). There was no association of FLG with asthma independent of eczema ( P = .15) and no association with seasonal rhinitis ( P = .66). Conclusion FLG null mutations are significantly associated with mild-to-moderate atopic eczema in childhood, with a recessive pattern of inheritance.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2008.01.013</identifier><identifier>PMID: 18313126</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Age ; Allergic diseases ; Allergy and Immunology ; Asthma ; Asthma - diagnosis ; Asthma - genetics ; Asthma - immunology ; atopic eczema ; Biological and medical sciences ; Case-Control Studies ; Child ; Children & youth ; Cohort Studies ; complex trait ; Deoxyribonucleic acid ; DNA ; Eczema ; Eczema - diagnosis ; Eczema - genetics ; Eczema - immunology ; Female ; filaggrin ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes, Recessive - immunology ; Genetic Carrier Screening ; Genetic testing ; Hay fever ; Humans ; Hypersensitivity, Immediate - diagnosis ; Hypersensitivity, Immediate - genetics ; Hypersensitivity, Immediate - immunology ; ichthyosis vulgaris ; Immunopathology ; Intermediate Filament Proteins - deficiency ; Intermediate Filament Proteins - genetics ; Intermediate Filament Proteins - physiology ; Male ; Medical sciences ; Mutation ; Population ; Questionnaires ; Rhinitis, Allergic, Seasonal - diagnosis ; Rhinitis, Allergic, Seasonal - genetics ; Rhinitis, Allergic, Seasonal - immunology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; seasonal rhinitis ; Skin ; Skin allergic diseases. Stinging insect allergies ; skin barrier function ; Studies ; Surveys and Questionnaires</subject><ispartof>Journal of allergy and clinical immunology, 2008-04, Vol.121 (4), p.940-946.e3</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2008 American Academy of Allergy, Asthma & Immunology</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Apr 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-95a8369a871a0d3ee98ffced16189b43a7f7bd7f43a2be3ec464413987a918533</citedby><cites>FETCH-LOGICAL-c725t-95a8369a871a0d3ee98ffced16189b43a7f7bd7f43a2be3ec464413987a918533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674908001437$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20509289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18313126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Sara J., MRCP</creatorcontrib><creatorcontrib>Relton, Caroline L., PhD</creatorcontrib><creatorcontrib>Liao, Haihui, MD</creatorcontrib><creatorcontrib>Zhao, Yiwei, MD</creatorcontrib><creatorcontrib>Sandilands, Aileen, PhD</creatorcontrib><creatorcontrib>Wilson, Ian J., PhD</creatorcontrib><creatorcontrib>Burn, John, MD</creatorcontrib><creatorcontrib>Reynolds, Nick J., MD</creatorcontrib><creatorcontrib>McLean, W. H. Irwin, PhD, DSc</creatorcontrib><creatorcontrib>Cordell, Heather J., DPhil</creatorcontrib><title>Filaggrin null mutations and childhood atopic eczema: A population-based case-control study</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. Objective We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in an unselected population cohort. Methods Eight hundred eleven English children aged 7 to 9 years were screened for FLG mutations. Eczema cases were defined by using United Kingdom diagnostic criteria and skin examination. Asthma and seasonal rhinitis cases were defined by parental questionnaire. Association between phenotype and genotype was investigated using Fisher exact test and logistic regression analysis. Results The 12-month period prevalence of atopic eczema was 24.2% (95% CI, 21.2% to 27.2%), with 96% (115/120) of cases having mild-to-moderate disease. The combined null genotype (carriage of ≥1 FLG mutations) was significantly associated with atopic eczema ( P = 1.2 × 10−4 ). The odds ratio (OR) for individuals carrying 2 null mutations was 26.9 (95% CI, 3.3-217.1), but heterozygote carriers showed no significant increase in risk (OR, 1.2; 95% CI, 0.7-1.9). Eight of 190 eczema cases (4.2%) carried 2 FLG null mutations and thus might be attributed to filaggrin deficiency. Asthma in the context of eczema showed significant association with the FLG null mutations ( P = 7.1 × 10−4 ). There was no association of FLG with asthma independent of eczema ( P = .15) and no association with seasonal rhinitis ( P = .66). Conclusion FLG null mutations are significantly associated with mild-to-moderate atopic eczema in childhood, with a recessive pattern of inheritance.</description><subject>Age</subject><subject>Allergic diseases</subject><subject>Allergy and Immunology</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>atopic eczema</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>complex trait</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Eczema</subject><subject>Eczema - diagnosis</subject><subject>Eczema - genetics</subject><subject>Eczema - immunology</subject><subject>Female</subject><subject>filaggrin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes, Recessive - immunology</subject><subject>Genetic Carrier Screening</subject><subject>Genetic testing</subject><subject>Hay fever</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Hypersensitivity, Immediate - genetics</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>ichthyosis vulgaris</subject><subject>Immunopathology</subject><subject>Intermediate Filament Proteins - deficiency</subject><subject>Intermediate Filament Proteins - genetics</subject><subject>Intermediate Filament Proteins - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Rhinitis, Allergic, Seasonal - diagnosis</subject><subject>Rhinitis, Allergic, Seasonal - genetics</subject><subject>Rhinitis, Allergic, Seasonal - immunology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>seasonal rhinitis</subject><subject>Skin</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>skin barrier function</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFDEUhgdR7Fr9A17IgOjdrOckM5NEpFBKq0LBC_XKi5DNZHazZpM1mSmsv74Zd2m1Fy4c8kGe85Fz3qJ4iTBHwPbder5W2s4JAJ8DZqOPihmCYFXLSfO4mAEIrFpWi5PiWUpryHfKxdPiBDlFiqSdFT-urFPLZbS-9KNz5WYc1GCDT6XyXalX1nWrELpSDWFrdWn0b7NR78vzchu2o_uDVguVTGbzWunghxhcmYax2z0vnvTKJfPisJ8W368uv118qq6_fPx8cX5daUaaoRKN4rQVijNU0FFjBO97bTpskYtFTRXr2aJjfT6RhaFG121dIxWcKYG8ofS0ONvH3Y6Ljem0yTUoJ7fRblTcyaCs_PfF25VchhvZCsaxITnA20OAGH6NJg1yY5M2zilvwpgkg5qJVtCjIEGgKCg7DsJEkeMRUTQ1R1Zn8PUDcB3G6HNfJTZTfVkSIlNkT-kYUoqmv-sCgpxEI9dyEo2cRCMBs001vPq7f_cuB5Vk4M0BUEkr10fltU13HIEGBOFT9g97zuRp31gTZdLW-DxLG40eZBfs_-s4e-CunfU2Z_xpdibd_1cmIkF-neQ9qRs4ANa5n7e3bPSj</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Brown, Sara J., MRCP</creator><creator>Relton, Caroline L., PhD</creator><creator>Liao, Haihui, MD</creator><creator>Zhao, Yiwei, MD</creator><creator>Sandilands, Aileen, PhD</creator><creator>Wilson, Ian J., PhD</creator><creator>Burn, John, MD</creator><creator>Reynolds, Nick J., MD</creator><creator>McLean, W. H. Irwin, PhD, DSc</creator><creator>Cordell, Heather J., DPhil</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080401</creationdate><title>Filaggrin null mutations and childhood atopic eczema: A population-based case-control study</title><author>Brown, Sara J., MRCP ; Relton, Caroline L., PhD ; Liao, Haihui, MD ; Zhao, Yiwei, MD ; Sandilands, Aileen, PhD ; Wilson, Ian J., PhD ; Burn, John, MD ; Reynolds, Nick J., MD ; McLean, W. H. Irwin, PhD, DSc ; Cordell, Heather J., DPhil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-95a8369a871a0d3ee98ffced16189b43a7f7bd7f43a2be3ec464413987a918533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Allergic diseases</topic><topic>Allergy and Immunology</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>atopic eczema</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>complex trait</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Eczema</topic><topic>Eczema - diagnosis</topic><topic>Eczema - genetics</topic><topic>Eczema - immunology</topic><topic>Female</topic><topic>filaggrin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes, Recessive - immunology</topic><topic>Genetic Carrier Screening</topic><topic>Genetic testing</topic><topic>Hay fever</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - diagnosis</topic><topic>Hypersensitivity, Immediate - genetics</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>ichthyosis vulgaris</topic><topic>Immunopathology</topic><topic>Intermediate Filament Proteins - deficiency</topic><topic>Intermediate Filament Proteins - genetics</topic><topic>Intermediate Filament Proteins - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Rhinitis, Allergic, Seasonal - diagnosis</topic><topic>Rhinitis, Allergic, Seasonal - genetics</topic><topic>Rhinitis, Allergic, Seasonal - immunology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>seasonal rhinitis</topic><topic>Skin</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>skin barrier function</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Sara J., MRCP</creatorcontrib><creatorcontrib>Relton, Caroline L., PhD</creatorcontrib><creatorcontrib>Liao, Haihui, MD</creatorcontrib><creatorcontrib>Zhao, Yiwei, MD</creatorcontrib><creatorcontrib>Sandilands, Aileen, PhD</creatorcontrib><creatorcontrib>Wilson, Ian J., PhD</creatorcontrib><creatorcontrib>Burn, John, MD</creatorcontrib><creatorcontrib>Reynolds, Nick J., MD</creatorcontrib><creatorcontrib>McLean, W. H. Irwin, PhD, DSc</creatorcontrib><creatorcontrib>Cordell, Heather J., DPhil</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Sara J., MRCP</au><au>Relton, Caroline L., PhD</au><au>Liao, Haihui, MD</au><au>Zhao, Yiwei, MD</au><au>Sandilands, Aileen, PhD</au><au>Wilson, Ian J., PhD</au><au>Burn, John, MD</au><au>Reynolds, Nick J., MD</au><au>McLean, W. H. Irwin, PhD, DSc</au><au>Cordell, Heather J., DPhil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Filaggrin null mutations and childhood atopic eczema: A population-based case-control study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>121</volume><issue>4</issue><spage>940</spage><epage>946.e3</epage><pages>940-946.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. Objective We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in an unselected population cohort. Methods Eight hundred eleven English children aged 7 to 9 years were screened for FLG mutations. Eczema cases were defined by using United Kingdom diagnostic criteria and skin examination. Asthma and seasonal rhinitis cases were defined by parental questionnaire. Association between phenotype and genotype was investigated using Fisher exact test and logistic regression analysis. Results The 12-month period prevalence of atopic eczema was 24.2% (95% CI, 21.2% to 27.2%), with 96% (115/120) of cases having mild-to-moderate disease. The combined null genotype (carriage of ≥1 FLG mutations) was significantly associated with atopic eczema ( P = 1.2 × 10−4 ). The odds ratio (OR) for individuals carrying 2 null mutations was 26.9 (95% CI, 3.3-217.1), but heterozygote carriers showed no significant increase in risk (OR, 1.2; 95% CI, 0.7-1.9). Eight of 190 eczema cases (4.2%) carried 2 FLG null mutations and thus might be attributed to filaggrin deficiency. Asthma in the context of eczema showed significant association with the FLG null mutations ( P = 7.1 × 10−4 ). There was no association of FLG with asthma independent of eczema ( P = .15) and no association with seasonal rhinitis ( P = .66). Conclusion FLG null mutations are significantly associated with mild-to-moderate atopic eczema in childhood, with a recessive pattern of inheritance.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18313126</pmid><doi>10.1016/j.jaci.2008.01.013</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Allergic diseases Allergy and Immunology Asthma Asthma - diagnosis Asthma - genetics Asthma - immunology atopic eczema Biological and medical sciences Case-Control Studies Child Children & youth Cohort Studies complex trait Deoxyribonucleic acid DNA Eczema Eczema - diagnosis Eczema - genetics Eczema - immunology Female filaggrin Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Recessive - immunology Genetic Carrier Screening Genetic testing Hay fever Humans Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology ichthyosis vulgaris Immunopathology Intermediate Filament Proteins - deficiency Intermediate Filament Proteins - genetics Intermediate Filament Proteins - physiology Male Medical sciences Mutation Population Questionnaires Rhinitis, Allergic, Seasonal - diagnosis Rhinitis, Allergic, Seasonal - genetics Rhinitis, Allergic, Seasonal - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis seasonal rhinitis Skin Skin allergic diseases. Stinging insect allergies skin barrier function Studies Surveys and Questionnaires |
| title | Filaggrin null mutations and childhood atopic eczema: A population-based case-control study |
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