Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy
Aim To determine the feasibility and potential benefit of a full cardiac magnetic resonance (CMR) work-up for assessing the location of scarred myocardium and the region of latest contraction (LCR) in patients with ischaemic cardiomyopathy (ICM) undergoing cardiac resynchronisation therapy (CRT). Me...
Gespeichert in:
| Veröffentlicht in: | Netherlands heart journal 2020-02, Vol.28 (2), p.89-95 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 95 |
|---|---|
| container_issue | 2 |
| container_start_page | 89 |
| container_title | Netherlands heart journal |
| container_volume | 28 |
| creator | Gathier, W. A. Salden, O. A. E. van Ginkel, D. J. van Everdingen, W. M. Mohamed Hoesein, F. A. A. Cramer, M. J. M. Doevendans, P. A. Meine, M. Chamuleau, S. A. J. van Slochteren, F. J. |
| description | Aim
To determine the feasibility and potential benefit of a full cardiac magnetic resonance (CMR) work-up for assessing the location of scarred myocardium and the region of latest contraction (LCR) in patients with ischaemic cardiomyopathy (ICM) undergoing cardiac resynchronisation therapy (CRT).
Methods
In 30 patients, scar identification and contraction timing analysis was retrospectively performed on CMR images. Fluoroscopic left ventricular (LV) lead positions were scored with respect to scar location, and when placed outside scar, with respect to the LCR. The association between the lead position with respect to scar, the LCR and echocardiographic LV end-systolic volume (LVESV) reduction was subsequently evaluated.
Results
The CMR work-up was feasible in all but one patient, in whom image quality was poor. Scar and contraction timing data were succesfully displayed on 36-segment cardiac bullseye plots. Patients with leads placed outside scar had larger LVESV reduction (−21 ± 21%,
n
= 19) compared to patients with leads within scar (1 ± 25%,
n
= 11), yet total scar burden was higher in the latter group. There was a trend towards larger LVESV reduction in patients with leads in the scar-free LCR, compared to leads situated in scar-free segments but not in the LCR (−34 ± 14% vs −15 ± 21%,
p
= 0.06).
Conclusions
The degree of reverse remodelling was larger in patients with leads situated in a scar-free LCR. In patients with leads situated within scar there was a neutral effect on reverse remodelling, which can be caused both by higher scar burden or lead position. These findings demonstrate the feasibility of a CMR work-up and potential benefit in ICM patients undergoing CRT. |
| doi_str_mv | 10.1007/s12471-019-01360-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6977813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2341622200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-86d734efe97bb94ebb35e2bdbcfcf2223c56dd338af6342f9c7172c2b69c8ece3</originalsourceid><addsrcrecordid>eNp9Uclu1TAUjRAVLYUfYIEssWET8JDYzgYJPdGCVFSpKmvLdm4SV4kd7KQoP8L31q-vlGHBwrKlM9x7fIriFcHvCMbifSK0EqTEpMmHcVzyJ8UJkYKXnNb4aX7XXJa1lPK4eJ7SDca1oEQ8K44ZaWomRH1S_DwDnZxxo1s2pH2L5rCAX5wekQEPnVtQ6NAcoZxjsNCuMSO7r1fITbp3vkfOo1kvLmsS-uGWAblkBw2Ts8jq2LowbSEThg2tvoXYh73oHtEWRUibt0MM3qVsEjxaBoh63l4UR50eE7x8uE-Lb2efrnefy4vL8y-7jxelrUS1lJK3glXQQSOMaSowhtVATWtsZztKKbM1b1vGpO44q2jXWEEEtdTwxkqwwE6LDwffeTUTtDbHyAHVHHO8uKmgnfob8W5QfbhVvBFCEpYN3j4YxPB9hbSoKX8AjKP2ENakKKsIz5tgnKlv_qHehDX6HE9RQXMhjRR7Q3pg2RhSitA9LkOw2teuDrWrXLu6r13xLHr9Z4xHya-eM4EdCClDvof4e_Z_bO8AAMy-aA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729539873</pqid></control><display><type>article</type><title>Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Gathier, W. A. ; Salden, O. A. E. ; van Ginkel, D. J. ; van Everdingen, W. M. ; Mohamed Hoesein, F. A. A. ; Cramer, M. J. M. ; Doevendans, P. A. ; Meine, M. ; Chamuleau, S. A. J. ; van Slochteren, F. J.</creator><creatorcontrib>Gathier, W. A. ; Salden, O. A. E. ; van Ginkel, D. J. ; van Everdingen, W. M. ; Mohamed Hoesein, F. A. A. ; Cramer, M. J. M. ; Doevendans, P. A. ; Meine, M. ; Chamuleau, S. A. J. ; van Slochteren, F. J.</creatorcontrib><description>Aim
To determine the feasibility and potential benefit of a full cardiac magnetic resonance (CMR) work-up for assessing the location of scarred myocardium and the region of latest contraction (LCR) in patients with ischaemic cardiomyopathy (ICM) undergoing cardiac resynchronisation therapy (CRT).
Methods
In 30 patients, scar identification and contraction timing analysis was retrospectively performed on CMR images. Fluoroscopic left ventricular (LV) lead positions were scored with respect to scar location, and when placed outside scar, with respect to the LCR. The association between the lead position with respect to scar, the LCR and echocardiographic LV end-systolic volume (LVESV) reduction was subsequently evaluated.
Results
The CMR work-up was feasible in all but one patient, in whom image quality was poor. Scar and contraction timing data were succesfully displayed on 36-segment cardiac bullseye plots. Patients with leads placed outside scar had larger LVESV reduction (−21 ± 21%,
n
= 19) compared to patients with leads within scar (1 ± 25%,
n
= 11), yet total scar burden was higher in the latter group. There was a trend towards larger LVESV reduction in patients with leads in the scar-free LCR, compared to leads situated in scar-free segments but not in the LCR (−34 ± 14% vs −15 ± 21%,
p
= 0.06).
Conclusions
The degree of reverse remodelling was larger in patients with leads situated in a scar-free LCR. In patients with leads situated within scar there was a neutral effect on reverse remodelling, which can be caused both by higher scar burden or lead position. These findings demonstrate the feasibility of a CMR work-up and potential benefit in ICM patients undergoing CRT.</description><identifier>ISSN: 1568-5888</identifier><identifier>EISSN: 1876-6250</identifier><identifier>DOI: 10.1007/s12471-019-01360-6</identifier><identifier>PMID: 31953775</identifier><language>eng</language><publisher>Houten: Bohn Stafleu van Loghum</publisher><subject>Cardiology ; Cardiomyopathy ; Electrodes ; Heart failure ; Ischemia ; Magnetic resonance imaging ; Medical Education ; Medicine ; Medicine & Public Health ; Normal distribution ; Original ; Original Article ; Patients ; Software</subject><ispartof>Netherlands heart journal, 2020-02, Vol.28 (2), p.89-95</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-86d734efe97bb94ebb35e2bdbcfcf2223c56dd338af6342f9c7172c2b69c8ece3</citedby><cites>FETCH-LOGICAL-c474t-86d734efe97bb94ebb35e2bdbcfcf2223c56dd338af6342f9c7172c2b69c8ece3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977813/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977813/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31953775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gathier, W. A.</creatorcontrib><creatorcontrib>Salden, O. A. E.</creatorcontrib><creatorcontrib>van Ginkel, D. J.</creatorcontrib><creatorcontrib>van Everdingen, W. M.</creatorcontrib><creatorcontrib>Mohamed Hoesein, F. A. A.</creatorcontrib><creatorcontrib>Cramer, M. J. M.</creatorcontrib><creatorcontrib>Doevendans, P. A.</creatorcontrib><creatorcontrib>Meine, M.</creatorcontrib><creatorcontrib>Chamuleau, S. A. J.</creatorcontrib><creatorcontrib>van Slochteren, F. J.</creatorcontrib><title>Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy</title><title>Netherlands heart journal</title><addtitle>Neth Heart J</addtitle><addtitle>Neth Heart J</addtitle><description>Aim
To determine the feasibility and potential benefit of a full cardiac magnetic resonance (CMR) work-up for assessing the location of scarred myocardium and the region of latest contraction (LCR) in patients with ischaemic cardiomyopathy (ICM) undergoing cardiac resynchronisation therapy (CRT).
Methods
In 30 patients, scar identification and contraction timing analysis was retrospectively performed on CMR images. Fluoroscopic left ventricular (LV) lead positions were scored with respect to scar location, and when placed outside scar, with respect to the LCR. The association between the lead position with respect to scar, the LCR and echocardiographic LV end-systolic volume (LVESV) reduction was subsequently evaluated.
Results
The CMR work-up was feasible in all but one patient, in whom image quality was poor. Scar and contraction timing data were succesfully displayed on 36-segment cardiac bullseye plots. Patients with leads placed outside scar had larger LVESV reduction (−21 ± 21%,
n
= 19) compared to patients with leads within scar (1 ± 25%,
n
= 11), yet total scar burden was higher in the latter group. There was a trend towards larger LVESV reduction in patients with leads in the scar-free LCR, compared to leads situated in scar-free segments but not in the LCR (−34 ± 14% vs −15 ± 21%,
p
= 0.06).
Conclusions
The degree of reverse remodelling was larger in patients with leads situated in a scar-free LCR. In patients with leads situated within scar there was a neutral effect on reverse remodelling, which can be caused both by higher scar burden or lead position. These findings demonstrate the feasibility of a CMR work-up and potential benefit in ICM patients undergoing CRT.</description><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Electrodes</subject><subject>Heart failure</subject><subject>Ischemia</subject><subject>Magnetic resonance imaging</subject><subject>Medical Education</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Normal distribution</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Software</subject><issn>1568-5888</issn><issn>1876-6250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9Uclu1TAUjRAVLYUfYIEssWET8JDYzgYJPdGCVFSpKmvLdm4SV4kd7KQoP8L31q-vlGHBwrKlM9x7fIriFcHvCMbifSK0EqTEpMmHcVzyJ8UJkYKXnNb4aX7XXJa1lPK4eJ7SDca1oEQ8K44ZaWomRH1S_DwDnZxxo1s2pH2L5rCAX5wekQEPnVtQ6NAcoZxjsNCuMSO7r1fITbp3vkfOo1kvLmsS-uGWAblkBw2Ts8jq2LowbSEThg2tvoXYh73oHtEWRUibt0MM3qVsEjxaBoh63l4UR50eE7x8uE-Lb2efrnefy4vL8y-7jxelrUS1lJK3glXQQSOMaSowhtVATWtsZztKKbM1b1vGpO44q2jXWEEEtdTwxkqwwE6LDwffeTUTtDbHyAHVHHO8uKmgnfob8W5QfbhVvBFCEpYN3j4YxPB9hbSoKX8AjKP2ENakKKsIz5tgnKlv_qHehDX6HE9RQXMhjRR7Q3pg2RhSitA9LkOw2teuDrWrXLu6r13xLHr9Z4xHya-eM4EdCClDvof4e_Z_bO8AAMy-aA</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Gathier, W. A.</creator><creator>Salden, O. A. E.</creator><creator>van Ginkel, D. J.</creator><creator>van Everdingen, W. M.</creator><creator>Mohamed Hoesein, F. A. A.</creator><creator>Cramer, M. J. M.</creator><creator>Doevendans, P. A.</creator><creator>Meine, M.</creator><creator>Chamuleau, S. A. J.</creator><creator>van Slochteren, F. J.</creator><general>Bohn Stafleu van Loghum</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200201</creationdate><title>Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy</title><author>Gathier, W. A. ; Salden, O. A. E. ; van Ginkel, D. J. ; van Everdingen, W. M. ; Mohamed Hoesein, F. A. A. ; Cramer, M. J. M. ; Doevendans, P. A. ; Meine, M. ; Chamuleau, S. A. J. ; van Slochteren, F. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-86d734efe97bb94ebb35e2bdbcfcf2223c56dd338af6342f9c7172c2b69c8ece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Electrodes</topic><topic>Heart failure</topic><topic>Ischemia</topic><topic>Magnetic resonance imaging</topic><topic>Medical Education</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Normal distribution</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Software</topic><toplevel>online_resources</toplevel><creatorcontrib>Gathier, W. A.</creatorcontrib><creatorcontrib>Salden, O. A. E.</creatorcontrib><creatorcontrib>van Ginkel, D. J.</creatorcontrib><creatorcontrib>van Everdingen, W. M.</creatorcontrib><creatorcontrib>Mohamed Hoesein, F. A. A.</creatorcontrib><creatorcontrib>Cramer, M. J. M.</creatorcontrib><creatorcontrib>Doevendans, P. A.</creatorcontrib><creatorcontrib>Meine, M.</creatorcontrib><creatorcontrib>Chamuleau, S. A. J.</creatorcontrib><creatorcontrib>van Slochteren, F. J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Netherlands heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gathier, W. A.</au><au>Salden, O. A. E.</au><au>van Ginkel, D. J.</au><au>van Everdingen, W. M.</au><au>Mohamed Hoesein, F. A. A.</au><au>Cramer, M. J. M.</au><au>Doevendans, P. A.</au><au>Meine, M.</au><au>Chamuleau, S. A. J.</au><au>van Slochteren, F. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy</atitle><jtitle>Netherlands heart journal</jtitle><stitle>Neth Heart J</stitle><addtitle>Neth Heart J</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>28</volume><issue>2</issue><spage>89</spage><epage>95</epage><pages>89-95</pages><issn>1568-5888</issn><eissn>1876-6250</eissn><abstract>Aim
To determine the feasibility and potential benefit of a full cardiac magnetic resonance (CMR) work-up for assessing the location of scarred myocardium and the region of latest contraction (LCR) in patients with ischaemic cardiomyopathy (ICM) undergoing cardiac resynchronisation therapy (CRT).
Methods
In 30 patients, scar identification and contraction timing analysis was retrospectively performed on CMR images. Fluoroscopic left ventricular (LV) lead positions were scored with respect to scar location, and when placed outside scar, with respect to the LCR. The association between the lead position with respect to scar, the LCR and echocardiographic LV end-systolic volume (LVESV) reduction was subsequently evaluated.
Results
The CMR work-up was feasible in all but one patient, in whom image quality was poor. Scar and contraction timing data were succesfully displayed on 36-segment cardiac bullseye plots. Patients with leads placed outside scar had larger LVESV reduction (−21 ± 21%,
n
= 19) compared to patients with leads within scar (1 ± 25%,
n
= 11), yet total scar burden was higher in the latter group. There was a trend towards larger LVESV reduction in patients with leads in the scar-free LCR, compared to leads situated in scar-free segments but not in the LCR (−34 ± 14% vs −15 ± 21%,
p
= 0.06).
Conclusions
The degree of reverse remodelling was larger in patients with leads situated in a scar-free LCR. In patients with leads situated within scar there was a neutral effect on reverse remodelling, which can be caused both by higher scar burden or lead position. These findings demonstrate the feasibility of a CMR work-up and potential benefit in ICM patients undergoing CRT.</abstract><cop>Houten</cop><pub>Bohn Stafleu van Loghum</pub><pmid>31953775</pmid><doi>10.1007/s12471-019-01360-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1568-5888 |
| ispartof | Netherlands heart journal, 2020-02, Vol.28 (2), p.89-95 |
| issn | 1568-5888 1876-6250 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6977813 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Cardiology Cardiomyopathy Electrodes Heart failure Ischemia Magnetic resonance imaging Medical Education Medicine Medicine & Public Health Normal distribution Original Original Article Patients Software |
| title | Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T14%3A32%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasibility%20and%20potential%20benefit%20of%20pre-procedural%20CMR%20imaging%20in%20patients%20with%20ischaemic%20cardiomyopathy%20undergoing%20cardiac%20resynchronisation%20therapy&rft.jtitle=Netherlands%20heart%20journal&rft.au=Gathier,%20W.%20A.&rft.date=2020-02-01&rft.volume=28&rft.issue=2&rft.spage=89&rft.epage=95&rft.pages=89-95&rft.issn=1568-5888&rft.eissn=1876-6250&rft_id=info:doi/10.1007/s12471-019-01360-6&rft_dat=%3Cproquest_pubme%3E2341622200%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2729539873&rft_id=info:pmid/31953775&rfr_iscdi=true |