SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer
SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expre...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2020-01, Vol.12 (1), p.902-911 |
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| creator | Liu, Aiyu Zhang, Shizhen Li, Weihan Xu, Biao Lei, Rui Zhu, Shengmei |
| description | SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with significant poorer survival in breast cancer, especially the luminal A subtype. We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent
experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development. |
| doi_str_mv | 10.18632/aging.102663 |
| format | Article |
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experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.102663</identifier><identifier>PMID: 31926110</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Apoptosis - genetics ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Calcium-Binding Proteins - genetics ; Calcium-Binding Proteins - metabolism ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation - genetics ; Coatomer Protein - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Pregnancy ; Prognosis ; Research Paper ; Signal Transduction ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Aging (Albany, NY.), 2020-01, Vol.12 (1), p.902-911</ispartof><rights>Copyright © 2020 Liu et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-78c48d55810533ba91c2dc22f808b839339cb8d5e075a563bebf5d89a3224f173</citedby><cites>FETCH-LOGICAL-c457t-78c48d55810533ba91c2dc22f808b839339cb8d5e075a563bebf5d89a3224f173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31926110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Aiyu</creatorcontrib><creatorcontrib>Zhang, Shizhen</creatorcontrib><creatorcontrib>Li, Weihan</creatorcontrib><creatorcontrib>Xu, Biao</creatorcontrib><creatorcontrib>Lei, Rui</creatorcontrib><creatorcontrib>Zhu, Shengmei</creatorcontrib><title>SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with significant poorer survival in breast cancer, especially the luminal A subtype. We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent
experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development.</description><subject>Apoptosis - genetics</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Calcium-Binding Proteins - genetics</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Coatomer Protein - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Pregnancy</subject><subject>Prognosis</subject><subject>Research Paper</subject><subject>Signal Transduction</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLLDEQhYNc8TG6dCtZ3k2PeXTSyUbwDr5AUFC3hnQ63UZ6kr6pHh__3sZR0VUVVYdzDnwIHVAyp0pydmS7ELs5JUxKvoF2qC5FUQql__zYt9EuwBMhUohSbqFtTjWTlJId9HB7co7965A9QEgRW4Dkgh094JcwPuLF9c0_VmTfT6cGQ-ii7ac8bGODLR5Syj7jIacuJgiAQ8R19hZG7Gx0Pu-hzdb24Pc_5wzdn53eLS6Kq-vzy8XJVeFKUY1FpVypGiEUJYLz2mrqWOMYaxVRteKac-3qSeBJJayQvPZ1KxqlLWesbGnFZ-h47Tus6qVvnI9jtr0Zclja_GaSDeb3J4ZH06VnI3VVVYRNBn8_DXL6v_IwmmUA5_veRp9WYBjnkgmqp34zVKylLieA7NvvGErMBxPzwcSsmUz6w5_dvtVfEPg7Zd-JVw</recordid><startdate>20200111</startdate><enddate>20200111</enddate><creator>Liu, Aiyu</creator><creator>Zhang, Shizhen</creator><creator>Li, Weihan</creator><creator>Xu, Biao</creator><creator>Lei, Rui</creator><creator>Zhu, Shengmei</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200111</creationdate><title>SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer</title><author>Liu, Aiyu ; Zhang, Shizhen ; Li, Weihan ; Xu, Biao ; Lei, Rui ; Zhu, Shengmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-78c48d55810533ba91c2dc22f808b839339cb8d5e075a563bebf5d89a3224f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis - genetics</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Calcium-Binding Proteins - genetics</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Coatomer Protein - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Pregnancy</topic><topic>Prognosis</topic><topic>Research Paper</topic><topic>Signal Transduction</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Aiyu</creatorcontrib><creatorcontrib>Zhang, Shizhen</creatorcontrib><creatorcontrib>Li, Weihan</creatorcontrib><creatorcontrib>Xu, Biao</creatorcontrib><creatorcontrib>Lei, Rui</creatorcontrib><creatorcontrib>Zhu, Shengmei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Aiyu</au><au>Zhang, Shizhen</au><au>Li, Weihan</au><au>Xu, Biao</au><au>Lei, Rui</au><au>Zhu, Shengmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2020-01-11</date><risdate>2020</risdate><volume>12</volume><issue>1</issue><spage>902</spage><epage>911</epage><pages>902-911</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with significant poorer survival in breast cancer, especially the luminal A subtype. We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent
experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>31926110</pmid><doi>10.18632/aging.102663</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Apoptosis - genetics Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Coatomer Protein - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Pregnancy Prognosis Research Paper Signal Transduction Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism |
| title | SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer |
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