Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways

A range of new water-compatible optically pure metallohelices - made by self-assembly of simple non-peptidic organic components around Fe ions - exhibit similar architecture to some natural cationic antimicrobial peptides (CAMPs) and are found to have high, structure-dependent activity against bacte...

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Veröffentlicht in:	Chemical science (Cambridge) 2019-11, Vol.1 (42), p.978-972
Hauptverfasser:	Simpson, Daniel H, Hapeshi, Alexia, Rogers, Nicola J, Brabec, Viktor, Clarkson, Guy J, Fox, David J, Hrabina, Ondrej, Kay, Gemma L, King, Andrew K, Malina, Jaroslav, Millard, Andrew D, Moat, John, Roper, David I, Song, Hualong, Waterfield, Nicholas R, Scott, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Camps Chemistry Crystallography Deoxyribonucleic acid Disruption DNA E coli Gene sequencing Organic chemistry Pathogens Peptides Selectivity Self-assembly Virulence
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