Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

Background and Purpose Obesity, an important risk factor for developing chronic kidney disease (CKD), affects the kidneys by two main molecular signalling pathways: the endocannabinoid/CB1 receptor system, whose activation in obesity promotes renal inflammation, fibrosis, and injury, and the inducib...

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Veröffentlicht in:	British journal of pharmacology 2020-01, Vol.177 (1), p.110-127
Hauptverfasser:	Udi, Shiran, Hinden, Liad, Ahmad, Majdoleen, Drori, Adi, Iyer, Malliga R., Cinar, Resat, Herman‐Edelstein, Michal, Tam, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Bioavailability Cannabinoid CB1 receptors Chemical compounds Fibrosis High fat diet Kidney diseases Kidneys Magnetic resonance imaging Metabolism Nitric oxide Nitric-oxide synthase Obesity Oxidative stress Renal tubules Research Paper Research Papers Risk factors Signal transduction
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