Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis
Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of the association between MTHFR 677C>T polymorphism and risk of ovarian...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2019-09, Vol.20 (9), p.2569-2577 |
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| creator | Karimi-Zarchi, Mojgan Moghimi, Mansour Abbasi, Hajar Hadadan, Amaneh Salimi, Erfaneh Morovati-Sharifabad, Majid Akbarian-Bafghi, Mohammad Javad Zare-Shehneh, Masoud Mosavi-Jarrahi, Alireza Neamatzadeh, Hossein |
| description | Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to
ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of
the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed
a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed,
Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The
strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27
case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990
cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism
not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models.
However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated
with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The
results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of
ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise
role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk. |
| doi_str_mv | 10.31557/APJCP.2019.20.9.2569 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6976840</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31554347</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3269-5a0929d06c79ec2f44042f6c1848899c1982fd12789f70d047b7036ffbdcd35e3</originalsourceid><addsrcrecordid>eNpVkV1LwzAUhoMofkx_gpI_0JmmadJ4IZTiJxsbOsG7kKWJi7TNSLpJr_3j1k1l3rznQPI-5-IB4DxGwyROU3aZTx-L6RCjmPcx7COlfA8cY8JoxCh-3d_Zj8BJCO8IkTRj6SE4-iaQhLBj8JmH4JSVrXUNdAaOZ_e3T5AyVlzP4NRVXe38cmFDDT9su4DPq6D0srVzW9m2g62Dk7X0VjZQNiUstF9bJStYyEZpH65gDp-70Oq65yv4pNdWf2x-jnUro7yRVRdsOAUHRlZBn_3MAXi5vZkV99FocvdQ5KNIJZjyKJWIY14iqhjXChtCEMGGqjgjWca5inmGTRljlnHDUIkImzOUUGPmpSqTVCcDcL3lLlfzWpdKN62XlVh6W0vfCSet-P_S2IV4c2tBOaMZQT0g3QKUdyF4bf66MRIbK2JjRXxb6UP00Vvpexe7h_9avxqSL6FeiwM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Karimi-Zarchi, Mojgan ; Moghimi, Mansour ; Abbasi, Hajar ; Hadadan, Amaneh ; Salimi, Erfaneh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohammad Javad ; Zare-Shehneh, Masoud ; Mosavi-Jarrahi, Alireza ; Neamatzadeh, Hossein</creator><creatorcontrib>Karimi-Zarchi, Mojgan ; Moghimi, Mansour ; Abbasi, Hajar ; Hadadan, Amaneh ; Salimi, Erfaneh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohammad Javad ; Zare-Shehneh, Masoud ; Mosavi-Jarrahi, Alireza ; Neamatzadeh, Hossein</creatorcontrib><description>Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to
ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of
the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed
a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed,
Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The
strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27
case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990
cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism
not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models.
However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated
with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The
results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of
ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise
role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2019.20.9.2569</identifier><identifier>PMID: 31554347</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Ovarian Neoplasms - etiology ; Ovarian Neoplasms - pathology ; Polymorphism, Single Nucleotide ; Prognosis ; Review ; Risk Factors ; Uterine Cervical Neoplasms - etiology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2019-09, Vol.20 (9), p.2569-2577</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3269-5a0929d06c79ec2f44042f6c1848899c1982fd12789f70d047b7036ffbdcd35e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976840/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976840/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31554347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karimi-Zarchi, Mojgan</creatorcontrib><creatorcontrib>Moghimi, Mansour</creatorcontrib><creatorcontrib>Abbasi, Hajar</creatorcontrib><creatorcontrib>Hadadan, Amaneh</creatorcontrib><creatorcontrib>Salimi, Erfaneh</creatorcontrib><creatorcontrib>Morovati-Sharifabad, Majid</creatorcontrib><creatorcontrib>Akbarian-Bafghi, Mohammad Javad</creatorcontrib><creatorcontrib>Zare-Shehneh, Masoud</creatorcontrib><creatorcontrib>Mosavi-Jarrahi, Alireza</creatorcontrib><creatorcontrib>Neamatzadeh, Hossein</creatorcontrib><title>Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to
ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of
the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed
a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed,
Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The
strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27
case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990
cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism
not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models.
However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated
with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The
results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of
ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise
role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk.</description><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Ovarian Neoplasms - etiology</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1LwzAUhoMofkx_gpI_0JmmadJ4IZTiJxsbOsG7kKWJi7TNSLpJr_3j1k1l3rznQPI-5-IB4DxGwyROU3aZTx-L6RCjmPcx7COlfA8cY8JoxCh-3d_Zj8BJCO8IkTRj6SE4-iaQhLBj8JmH4JSVrXUNdAaOZ_e3T5AyVlzP4NRVXe38cmFDDT9su4DPq6D0srVzW9m2g62Dk7X0VjZQNiUstF9bJStYyEZpH65gDp-70Oq65yv4pNdWf2x-jnUro7yRVRdsOAUHRlZBn_3MAXi5vZkV99FocvdQ5KNIJZjyKJWIY14iqhjXChtCEMGGqjgjWca5inmGTRljlnHDUIkImzOUUGPmpSqTVCcDcL3lLlfzWpdKN62XlVh6W0vfCSet-P_S2IV4c2tBOaMZQT0g3QKUdyF4bf66MRIbK2JjRXxb6UP00Vvpexe7h_9avxqSL6FeiwM</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Karimi-Zarchi, Mojgan</creator><creator>Moghimi, Mansour</creator><creator>Abbasi, Hajar</creator><creator>Hadadan, Amaneh</creator><creator>Salimi, Erfaneh</creator><creator>Morovati-Sharifabad, Majid</creator><creator>Akbarian-Bafghi, Mohammad Javad</creator><creator>Zare-Shehneh, Masoud</creator><creator>Mosavi-Jarrahi, Alireza</creator><creator>Neamatzadeh, Hossein</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis</title><author>Karimi-Zarchi, Mojgan ; Moghimi, Mansour ; Abbasi, Hajar ; Hadadan, Amaneh ; Salimi, Erfaneh ; Morovati-Sharifabad, Majid ; Akbarian-Bafghi, Mohammad Javad ; Zare-Shehneh, Masoud ; Mosavi-Jarrahi, Alireza ; Neamatzadeh, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3269-5a0929d06c79ec2f44042f6c1848899c1982fd12789f70d047b7036ffbdcd35e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Ovarian Neoplasms - etiology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karimi-Zarchi, Mojgan</creatorcontrib><creatorcontrib>Moghimi, Mansour</creatorcontrib><creatorcontrib>Abbasi, Hajar</creatorcontrib><creatorcontrib>Hadadan, Amaneh</creatorcontrib><creatorcontrib>Salimi, Erfaneh</creatorcontrib><creatorcontrib>Morovati-Sharifabad, Majid</creatorcontrib><creatorcontrib>Akbarian-Bafghi, Mohammad Javad</creatorcontrib><creatorcontrib>Zare-Shehneh, Masoud</creatorcontrib><creatorcontrib>Mosavi-Jarrahi, Alireza</creatorcontrib><creatorcontrib>Neamatzadeh, Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karimi-Zarchi, Mojgan</au><au>Moghimi, Mansour</au><au>Abbasi, Hajar</au><au>Hadadan, Amaneh</au><au>Salimi, Erfaneh</au><au>Morovati-Sharifabad, Majid</au><au>Akbarian-Bafghi, Mohammad Javad</au><au>Zare-Shehneh, Masoud</au><au>Mosavi-Jarrahi, Alireza</au><au>Neamatzadeh, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>20</volume><issue>9</issue><spage>2569</spage><epage>2577</epage><pages>2569-2577</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to
ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of
the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed
a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed,
Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The
strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27
case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990
cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism
not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models.
However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated
with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The
results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of
ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise
role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>31554347</pmid><doi>10.31557/APJCP.2019.20.9.2569</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2476-762X |
| ispartof | Asian Pacific Journal of Cancer Prevention, 2019-09, Vol.20 (9), p.2569-2577 |
| issn | 2476-762X 1513-7368 2476-762X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6976840 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free E- Journals |
| subjects | Case-Control Studies Female Genetic Predisposition to Disease Humans Methylenetetrahydrofolate Reductase (NADPH2) - genetics Ovarian Neoplasms - etiology Ovarian Neoplasms - pathology Polymorphism, Single Nucleotide Prognosis Review Risk Factors Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - pathology |
| title | Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis |
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