Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival
Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three fem...
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| creator | Granados-Soler, José Luis Bornemann-Kolatzki, Kirsten Beck, Julia Brenig, Bertram Schütz, Ekkehard Betz, Daniela Junginger, Johannes Hewicker-Trautwein, Marion Murua Escobar, Hugo Nolte, Ingo |
| description | Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three female cats with FMCs were followed during two years after surgery. Tumours represented tubulopapillary and solid carcinomas encompassing six molecular subtypes. Regardless of the histopathological diagnosis, molecular subtypes showed important differences in survival. Luminal A tumours exhibited the highest DFS (
p
= 0.002) and cancer-specific OS (
p
= 0.001), and the lowest amount of CNVs (
p
= 0.0001). In contrast, basal-like triple-negative FMCs had the worst outcome (DFS,
p
|
| doi_str_mv | 10.1038/s41598-020-57942-7 |
| format | Article |
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p
= 0.002) and cancer-specific OS (
p
= 0.001), and the lowest amount of CNVs (
p
= 0.0001). In contrast, basal-like triple-negative FMCs had the worst outcome (DFS,
p
< 0.0001; and OS,
p
< 0.00001) and were the most aberrant (
p
= 0.05). In the multivariate analysis, copy-number losses (CNLs) in chromosome B1 (1–23 Mb) harbouring several tumour-repressors (e.g.
CSMD1
,
MTUS1
,
MSR1
,
DBC2
, and
TUSC3
) negatively influenced DFS. Whereas, copy-number gains (CNGs) in B4 (1–29 Mb) and F2 (64–82.3 Mb) comprising epithelial to mesenchymal transition genes and metastasis-promoting transcription factors (e.g.
GATA3
,
VIM
,
ZEB1
, and
MYC
) negatively influenced DFS and cancer-specific OS. These data evidence an association between specific CNVs in chromosomes B1, B4 and F2, and poor prognosis in FMCs.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-57942-7</identifier><identifier>PMID: 31969654</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/23 ; 631/67/1347 ; 692/308/575 ; 692/4017 ; 692/4028/67/1347 ; Animals ; Breast cancer ; Cancer ; Cat Diseases - genetics ; Cat Diseases - mortality ; Cat Diseases - pathology ; Cats ; Chromosomes ; DNA Copy Number Variations - genetics ; Female ; GATA-3 protein ; High-Throughput Nucleotide Sequencing - veterinary ; Humanities and Social Sciences ; Mammary gland ; Mammary Neoplasms, Animal - genetics ; Mammary Neoplasms, Animal - mortality ; Mammary Neoplasms, Animal - pathology ; Medical prognosis ; Mesenchyme ; Metastases ; multidisciplinary ; Multivariate analysis ; Myc protein ; Next-generation sequencing ; Repressors ; Science ; Science (multidisciplinary) ; Surgery ; Survival ; Survival Analysis ; Transcription factors ; Tumors</subject><ispartof>Scientific reports, 2020-01, Vol.10 (1), p.1003-1003, Article 1003</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b198d0a4543de05c5cfac57da2043589d8b6486999efdc0ca4c72a09c6ac996c3</citedby><cites>FETCH-LOGICAL-c474t-b198d0a4543de05c5cfac57da2043589d8b6486999efdc0ca4c72a09c6ac996c3</cites><orcidid>0000-0001-6860-0166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976565/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976565/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31969654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Granados-Soler, José Luis</creatorcontrib><creatorcontrib>Bornemann-Kolatzki, Kirsten</creatorcontrib><creatorcontrib>Beck, Julia</creatorcontrib><creatorcontrib>Brenig, Bertram</creatorcontrib><creatorcontrib>Schütz, Ekkehard</creatorcontrib><creatorcontrib>Betz, Daniela</creatorcontrib><creatorcontrib>Junginger, Johannes</creatorcontrib><creatorcontrib>Hewicker-Trautwein, Marion</creatorcontrib><creatorcontrib>Murua Escobar, Hugo</creatorcontrib><creatorcontrib>Nolte, Ingo</creatorcontrib><title>Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three female cats with FMCs were followed during two years after surgery. Tumours represented tubulopapillary and solid carcinomas encompassing six molecular subtypes. Regardless of the histopathological diagnosis, molecular subtypes showed important differences in survival. Luminal A tumours exhibited the highest DFS (
p
= 0.002) and cancer-specific OS (
p
= 0.001), and the lowest amount of CNVs (
p
= 0.0001). In contrast, basal-like triple-negative FMCs had the worst outcome (DFS,
p
< 0.0001; and OS,
p
< 0.00001) and were the most aberrant (
p
= 0.05). In the multivariate analysis, copy-number losses (CNLs) in chromosome B1 (1–23 Mb) harbouring several tumour-repressors (e.g.
CSMD1
,
MTUS1
,
MSR1
,
DBC2
, and
TUSC3
) negatively influenced DFS. Whereas, copy-number gains (CNGs) in B4 (1–29 Mb) and F2 (64–82.3 Mb) comprising epithelial to mesenchymal transition genes and metastasis-promoting transcription factors (e.g.
GATA3
,
VIM
,
ZEB1
, and
MYC
) negatively influenced DFS and cancer-specific OS. These data evidence an association between specific CNVs in chromosomes B1, B4 and F2, and poor prognosis in FMCs.</description><subject>45</subject><subject>45/23</subject><subject>631/67/1347</subject><subject>692/308/575</subject><subject>692/4017</subject><subject>692/4028/67/1347</subject><subject>Animals</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cat Diseases - genetics</subject><subject>Cat Diseases - mortality</subject><subject>Cat Diseases - pathology</subject><subject>Cats</subject><subject>Chromosomes</subject><subject>DNA Copy Number Variations - genetics</subject><subject>Female</subject><subject>GATA-3 protein</subject><subject>High-Throughput Nucleotide Sequencing - veterinary</subject><subject>Humanities and Social Sciences</subject><subject>Mammary gland</subject><subject>Mammary Neoplasms, Animal - genetics</subject><subject>Mammary Neoplasms, Animal - mortality</subject><subject>Mammary Neoplasms, Animal - pathology</subject><subject>Medical prognosis</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>multidisciplinary</subject><subject>Multivariate analysis</subject><subject>Myc protein</subject><subject>Next-generation sequencing</subject><subject>Repressors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Transcription factors</subject><subject>Tumors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUlPwzAQhS0EAgT8AQ4oEhcuAcdb4gsSqtgklgPL1Zo6TnGV2MVuKvXf49JSlgO-jKX55vl5HkKHBT4tMK3OIiu4rHJMcM5LyUhebqBdghnPCSVk88d9Bx3EOMbpcCJZIbfRDi2kkIKzXXRz4aCdRxsz32QDP5nnD303NCF7hWBhar2LGbg6uzKtdSa7h66DMM8GELR1voPsqQ8zO4N2H2010EZzsKp76OXq8nlwk989Xt8OLu5yzUo2zYeFrGoMjDNaG8w11w1oXtaQ7FJeyboaClYJKaVpao01MF0SwFIL0FIKTffQ-VJ30g87U2vjpgFaNQl2YUx5sOp3x9k3NfIzJWQpuOBJ4GQlEPx7b-JUdTZq07bgjO-jIpQxQkRRkYQe_0HHvg9pYZ8UZVXJ5UKQLCkdfIzBNGszBVaLrNQyK5WyUp9ZqTINHf38xnrkK5kE0CUQU8uNTPh--x_ZD8g3n38</recordid><startdate>20200122</startdate><enddate>20200122</enddate><creator>Granados-Soler, José Luis</creator><creator>Bornemann-Kolatzki, Kirsten</creator><creator>Beck, Julia</creator><creator>Brenig, Bertram</creator><creator>Schütz, Ekkehard</creator><creator>Betz, Daniela</creator><creator>Junginger, Johannes</creator><creator>Hewicker-Trautwein, Marion</creator><creator>Murua Escobar, Hugo</creator><creator>Nolte, Ingo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6860-0166</orcidid></search><sort><creationdate>20200122</creationdate><title>Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival</title><author>Granados-Soler, José Luis ; Bornemann-Kolatzki, Kirsten ; Beck, Julia ; Brenig, Bertram ; Schütz, Ekkehard ; Betz, Daniela ; Junginger, Johannes ; Hewicker-Trautwein, Marion ; Murua Escobar, Hugo ; Nolte, Ingo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b198d0a4543de05c5cfac57da2043589d8b6486999efdc0ca4c72a09c6ac996c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>45</topic><topic>45/23</topic><topic>631/67/1347</topic><topic>692/308/575</topic><topic>692/4017</topic><topic>692/4028/67/1347</topic><topic>Animals</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cat Diseases - genetics</topic><topic>Cat Diseases - mortality</topic><topic>Cat Diseases - pathology</topic><topic>Cats</topic><topic>Chromosomes</topic><topic>DNA Copy Number Variations - genetics</topic><topic>Female</topic><topic>GATA-3 protein</topic><topic>High-Throughput Nucleotide Sequencing - veterinary</topic><topic>Humanities and Social Sciences</topic><topic>Mammary gland</topic><topic>Mammary Neoplasms, Animal - genetics</topic><topic>Mammary Neoplasms, Animal - mortality</topic><topic>Mammary Neoplasms, Animal - pathology</topic><topic>Medical prognosis</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>multidisciplinary</topic><topic>Multivariate analysis</topic><topic>Myc protein</topic><topic>Next-generation sequencing</topic><topic>Repressors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Transcription factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Granados-Soler, José Luis</creatorcontrib><creatorcontrib>Bornemann-Kolatzki, Kirsten</creatorcontrib><creatorcontrib>Beck, Julia</creatorcontrib><creatorcontrib>Brenig, Bertram</creatorcontrib><creatorcontrib>Schütz, Ekkehard</creatorcontrib><creatorcontrib>Betz, Daniela</creatorcontrib><creatorcontrib>Junginger, Johannes</creatorcontrib><creatorcontrib>Hewicker-Trautwein, Marion</creatorcontrib><creatorcontrib>Murua Escobar, Hugo</creatorcontrib><creatorcontrib>Nolte, Ingo</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Granados-Soler, José Luis</au><au>Bornemann-Kolatzki, Kirsten</au><au>Beck, Julia</au><au>Brenig, Bertram</au><au>Schütz, Ekkehard</au><au>Betz, Daniela</au><au>Junginger, Johannes</au><au>Hewicker-Trautwein, Marion</au><au>Murua Escobar, Hugo</au><au>Nolte, Ingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-01-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>1003</spage><epage>1003</epage><pages>1003-1003</pages><artnum>1003</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three female cats with FMCs were followed during two years after surgery. Tumours represented tubulopapillary and solid carcinomas encompassing six molecular subtypes. Regardless of the histopathological diagnosis, molecular subtypes showed important differences in survival. Luminal A tumours exhibited the highest DFS (
p
= 0.002) and cancer-specific OS (
p
= 0.001), and the lowest amount of CNVs (
p
= 0.0001). In contrast, basal-like triple-negative FMCs had the worst outcome (DFS,
p
< 0.0001; and OS,
p
< 0.00001) and were the most aberrant (
p
= 0.05). In the multivariate analysis, copy-number losses (CNLs) in chromosome B1 (1–23 Mb) harbouring several tumour-repressors (e.g.
CSMD1
,
MTUS1
,
MSR1
,
DBC2
, and
TUSC3
) negatively influenced DFS. Whereas, copy-number gains (CNGs) in B4 (1–29 Mb) and F2 (64–82.3 Mb) comprising epithelial to mesenchymal transition genes and metastasis-promoting transcription factors (e.g.
GATA3
,
VIM
,
ZEB1
, and
MYC
) negatively influenced DFS and cancer-specific OS. These data evidence an association between specific CNVs in chromosomes B1, B4 and F2, and poor prognosis in FMCs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31969654</pmid><doi>10.1038/s41598-020-57942-7</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6860-0166</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 45 45/23 631/67/1347 692/308/575 692/4017 692/4028/67/1347 Animals Breast cancer Cancer Cat Diseases - genetics Cat Diseases - mortality Cat Diseases - pathology Cats Chromosomes DNA Copy Number Variations - genetics Female GATA-3 protein High-Throughput Nucleotide Sequencing - veterinary Humanities and Social Sciences Mammary gland Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - mortality Mammary Neoplasms, Animal - pathology Medical prognosis Mesenchyme Metastases multidisciplinary Multivariate analysis Myc protein Next-generation sequencing Repressors Science Science (multidisciplinary) Surgery Survival Survival Analysis Transcription factors Tumors |
| title | Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival |
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