One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens
Background: The purpose of this study was to: a) compare rates of local reactions from meningococcal C conjugate (Neis Vac-C®) and hepatitis B vaccines (Recombivax HB®) , and b) compare local reactions when both injections were given in one arm versus one in each arm. Methods: Schools were randomize...
Gespeichert in:
| Veröffentlicht in: | Canadian journal of public health 2008-01, Vol.99 (1), p.52-56 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 56 |
|---|---|
| container_issue | 1 |
| container_start_page | 52 |
| container_title | Canadian journal of public health |
| container_volume | 99 |
| creator | Pielak, Karen L. McIntyre, Cheryl C. Remple, Valencia P. Buxton, Jane A. Skowronski, Danuta M. |
| description | Background: The purpose of this study was to: a) compare rates of local reactions from meningococcal C conjugate (Neis Vac-C®) and hepatitis B vaccines (Recombivax HB®) , and b) compare local reactions when both injections were given in one arm versus one in each arm. Methods: Schools were randomized to have grade six students receive both vaccines in one arm (One Arm Group), or one vaccine in each arm (Two Arm Group; MCC always given in left arm). Structured telephone interviews of parents were conducted, and respondents were asked about local and systemic reactions, interference with school or other activities, need for medical attention, and lost parental work time. Findings: The Two Arm Group reported significantly more local redness >46 mm (6.5% vs. 0.5%, p |
| doi_str_mv | 10.1007/BF03403741 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6976231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>41995033</jstor_id><sourcerecordid>41995033</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-f6e96f7b46d65526c0077ef79858d148eff252e047017b0fcb2cd2dc57521c73</originalsourceid><addsrcrecordid>eNptks-LEzEcxYMobl29eFeCsBdlNL8zc1G6xXWFlfVQvA5p5pua0ibdJOPif2-WKa2CpxC-H95737wg9JKS95QQ_eHyinBBuBb0EZrRjpFGC60eoxkhpG0EU_wMPct5U6-ca_4UndFWcMk7NkPb2wB4nnY4Jry8j5_wIgY7pgSh4Pmw88HnkkzxMeDo8DcIPqyjjdaaLV48wJtxbQpgEwZ8DftKFp_xJf5hrPUBMvYBf0_QFICQn6MnzmwzvDic52h59Xm5uG5ubr98XcxvGisYLY1T0CmnV0INSkqmbF1Sg9NdK9uBihacY5IBEZpQvSLOrpgd2GClloxazc_Rx0l2P652MNi6SzLbfp_8zqTffTS-_3cS_M9-HX_1qtOKcVoF3hwEUrwbIZd-E8cUauSecVbTTNDbCbIp5pzAHQ0o6R966U-9VPj135FO6KGIClwcAJPr27pkgvX5yFVTSZjoKvdu4nIdhTWkU7T_2r6a6E0uMR3VBO06Wf8C_wPowKvr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232007231</pqid></control><display><type>article</type><title>One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Pielak, Karen L. ; McIntyre, Cheryl C. ; Remple, Valencia P. ; Buxton, Jane A. ; Skowronski, Danuta M.</creator><creatorcontrib>Pielak, Karen L. ; McIntyre, Cheryl C. ; Remple, Valencia P. ; Buxton, Jane A. ; Skowronski, Danuta M.</creatorcontrib><description><![CDATA[Background: The purpose of this study was to: a) compare rates of local reactions from meningococcal C conjugate (Neis Vac-C®) and hepatitis B vaccines (Recombivax HB®) , and b) compare local reactions when both injections were given in one arm versus one in each arm. Methods: Schools were randomized to have grade six students receive both vaccines in one arm (One Arm Group), or one vaccine in each arm (Two Arm Group; MCC always given in left arm). Structured telephone interviews of parents were conducted, and respondents were asked about local and systemic reactions, interference with school or other activities, need for medical attention, and lost parental work time. Findings: The Two Arm Group reported significantly more local redness >46 mm (6.5% vs. 0.5%, p<0.001), moderate to severe tenderness (28% vs. 18%, p<0.05), and drowsiness (14% vs. 7%, p<0.05). When adjusted for sex, ethnicity, and town of residence, report of any tenderness was associated with town of residence only; moderate or severe tenderness was independently associated with the Two Arm Group (OR 1.4, 95% CI 1.1-1.85). There were no statistically significant differences between groups for interference with school attendance or other activities, need for medical attention, or lost parental work time. Among participants of the Two Arm Group (188 students), there was more redness (6% vs. 2%, p<0.05) and tenderness (54% vs. 32%, p<0.001) experienced with Neis Vac-C® than with Recombivax HB®, respectively. Conclusions: Injecting two vaccines in one arm did not cause more local reaction than one injection in each arm and remains an option for those who prefer it for logistical reasons. If vaccinating in two arms, Neis Vac-C® should preferentially be given in the non-dominant arm. Contexte : Cette étude visait : a) à comparer les taux de réaction au point d'injection du vaccin conjugué contre le méningocoque du groupe C (Neis Vac-C®) et du vaccin contre l'hépatite B (Recombivax HB®) et b) à comparer les réactions au point d'injection lorsque les deux vaccins sont administrés dans le même bras ou un dans chaque bras. Méthode : Dans deux groupes d'écoles sélectionnées aléatoirement, des élèves de 6e année ont reçu les deux vaccins dans le même bras (groupe « un bras ») ou un vaccin dans chaque bras (groupe « deux bras »; le vaccin antiméningococcique était toujours administré dans le bras gauche). Des entrevues téléphoniques structurées ont été menées auprès des parents; les répondants ont été interrogés sur les réactions systémiques et au point d'injection, sur les conflits avec les activités scolaires ou autres, sur la nécessité de recevoir des soins médicaux et sur les heures de travail perdues par les parents. Résultats : Le groupe « deux bras » a déclaré une proportion significativement plus élevée de rougeur de la peau >46 mm au point d'injection (6,5 % c. 0,5 %, p<0,001), de sensibilité modérée à grave au toucher (28 % c. 18 %, p<0,05) et de somnolence (14 % c. 7 %, p<0,05). En rajustant les données selon le sexe, l'appartenance ethnique et la ville de résidence, les déclarations de sensibilité au toucher n'étaient plus associées qu'à la ville de résidence; une sensibilité modérée à grave était associée de façon indépendante au groupe « deux bras » (RC = 1,4; IC de 95 % = 1,1-1,85). Aucune différence significative n'a été observée entre les groupes pour ce qui est des conflits avec les activités scolaires ou autres, la nécessité de recevoir des soins médicaux ou les heures de travail perdues par les parents. Dans le groupe « deux bras » (188 élèves), on a observé davantage de rougeur (6 % c. 2 %, p<0,05) et de sensibilité au toucher (54 % c. 32 %, p<0,001), respectivement, avec le vaccin Neis Vac-C® qu'avec le Recombivax HB®. Conclusion : L'injection des deux vaccins dans le même bras n'a pas provoqué plus de réactions au point d'injection que la vaccination dans les deux bras; cela confirme que c'est une bonne option si on la préfère pour des raisons de logistique. Si l'on vaccine dans les deux bras, il est préférable d'administrer le Neis Vac-C® dans le bras non dominant.]]></description><identifier>ISSN: 0008-4263</identifier><identifier>EISSN: 1920-7476</identifier><identifier>DOI: 10.1007/BF03403741</identifier><identifier>PMID: 18435392</identifier><identifier>CODEN: CJPEA4</identifier><language>eng</language><publisher>Cham: Canadian Public Health Association</publisher><subject>Adolescent ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Binomial distribution ; Biological and medical sciences ; Child ; Clinical trials ; Data analysis ; Educational administration ; Ethnicity ; Health care administration ; Health Surveys ; Hepatitis B - prevention & control ; Hepatitis B vaccines ; Hepatitis B Vaccines - administration & dosage ; Hepatitis B Vaccines - adverse effects ; Hepatitis B virus ; Human bacterial diseases ; Human viral diseases ; Humans ; Immunization ; Immunization Programs ; Infectious diseases ; Medical sciences ; Medicine ; Medicine & Public Health ; Meningococcal Vaccines - administration & dosage ; Meningococcal Vaccines - adverse effects ; Miscellaneous ; Nursing students ; Parents & parenting ; Public Health ; Public Health Nursing ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; RESEARCH/RECHERCHE ; Sample size ; Schools ; Students ; Studies ; Surveys and Questionnaires ; Swelling ; Time Factors ; Urban areas ; Vaccination ; Vaccines ; Viral diseases ; Viral hepatitis</subject><ispartof>Canadian journal of public health, 2008-01, Vol.99 (1), p.52-56</ispartof><rights>The Canadian Public Health Association 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Canadian Public Health Association Jan/Feb 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-f6e96f7b46d65526c0077ef79858d148eff252e047017b0fcb2cd2dc57521c73</citedby><cites>FETCH-LOGICAL-c421t-f6e96f7b46d65526c0077ef79858d148eff252e047017b0fcb2cd2dc57521c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41995033$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41995033$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,4024,27923,27924,27925,41488,42557,51319,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20050249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18435392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pielak, Karen L.</creatorcontrib><creatorcontrib>McIntyre, Cheryl C.</creatorcontrib><creatorcontrib>Remple, Valencia P.</creatorcontrib><creatorcontrib>Buxton, Jane A.</creatorcontrib><creatorcontrib>Skowronski, Danuta M.</creatorcontrib><title>One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens</title><title>Canadian journal of public health</title><addtitle>Can J Public Health</addtitle><addtitle>Can J Public Health</addtitle><description><![CDATA[Background: The purpose of this study was to: a) compare rates of local reactions from meningococcal C conjugate (Neis Vac-C®) and hepatitis B vaccines (Recombivax HB®) , and b) compare local reactions when both injections were given in one arm versus one in each arm. Methods: Schools were randomized to have grade six students receive both vaccines in one arm (One Arm Group), or one vaccine in each arm (Two Arm Group; MCC always given in left arm). Structured telephone interviews of parents were conducted, and respondents were asked about local and systemic reactions, interference with school or other activities, need for medical attention, and lost parental work time. Findings: The Two Arm Group reported significantly more local redness >46 mm (6.5% vs. 0.5%, p<0.001), moderate to severe tenderness (28% vs. 18%, p<0.05), and drowsiness (14% vs. 7%, p<0.05). When adjusted for sex, ethnicity, and town of residence, report of any tenderness was associated with town of residence only; moderate or severe tenderness was independently associated with the Two Arm Group (OR 1.4, 95% CI 1.1-1.85). There were no statistically significant differences between groups for interference with school attendance or other activities, need for medical attention, or lost parental work time. Among participants of the Two Arm Group (188 students), there was more redness (6% vs. 2%, p<0.05) and tenderness (54% vs. 32%, p<0.001) experienced with Neis Vac-C® than with Recombivax HB®, respectively. Conclusions: Injecting two vaccines in one arm did not cause more local reaction than one injection in each arm and remains an option for those who prefer it for logistical reasons. If vaccinating in two arms, Neis Vac-C® should preferentially be given in the non-dominant arm. Contexte : Cette étude visait : a) à comparer les taux de réaction au point d'injection du vaccin conjugué contre le méningocoque du groupe C (Neis Vac-C®) et du vaccin contre l'hépatite B (Recombivax HB®) et b) à comparer les réactions au point d'injection lorsque les deux vaccins sont administrés dans le même bras ou un dans chaque bras. Méthode : Dans deux groupes d'écoles sélectionnées aléatoirement, des élèves de 6e année ont reçu les deux vaccins dans le même bras (groupe « un bras ») ou un vaccin dans chaque bras (groupe « deux bras »; le vaccin antiméningococcique était toujours administré dans le bras gauche). Des entrevues téléphoniques structurées ont été menées auprès des parents; les répondants ont été interrogés sur les réactions systémiques et au point d'injection, sur les conflits avec les activités scolaires ou autres, sur la nécessité de recevoir des soins médicaux et sur les heures de travail perdues par les parents. Résultats : Le groupe « deux bras » a déclaré une proportion significativement plus élevée de rougeur de la peau >46 mm au point d'injection (6,5 % c. 0,5 %, p<0,001), de sensibilité modérée à grave au toucher (28 % c. 18 %, p<0,05) et de somnolence (14 % c. 7 %, p<0,05). En rajustant les données selon le sexe, l'appartenance ethnique et la ville de résidence, les déclarations de sensibilité au toucher n'étaient plus associées qu'à la ville de résidence; une sensibilité modérée à grave était associée de façon indépendante au groupe « deux bras » (RC = 1,4; IC de 95 % = 1,1-1,85). Aucune différence significative n'a été observée entre les groupes pour ce qui est des conflits avec les activités scolaires ou autres, la nécessité de recevoir des soins médicaux ou les heures de travail perdues par les parents. Dans le groupe « deux bras » (188 élèves), on a observé davantage de rougeur (6 % c. 2 %, p<0,05) et de sensibilité au toucher (54 % c. 32 %, p<0,001), respectivement, avec le vaccin Neis Vac-C® qu'avec le Recombivax HB®. Conclusion : L'injection des deux vaccins dans le même bras n'a pas provoqué plus de réactions au point d'injection que la vaccination dans les deux bras; cela confirme que c'est une bonne option si on la préfère pour des raisons de logistique. Si l'on vaccine dans les deux bras, il est préférable d'administrer le Neis Vac-C® dans le bras non dominant.]]></description><subject>Adolescent</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Binomial distribution</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Clinical trials</subject><subject>Data analysis</subject><subject>Educational administration</subject><subject>Ethnicity</subject><subject>Health care administration</subject><subject>Health Surveys</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B vaccines</subject><subject>Hepatitis B Vaccines - administration & dosage</subject><subject>Hepatitis B Vaccines - adverse effects</subject><subject>Hepatitis B virus</subject><subject>Human bacterial diseases</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Programs</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Meningococcal Vaccines - adverse effects</subject><subject>Miscellaneous</subject><subject>Nursing students</subject><subject>Parents & parenting</subject><subject>Public Health</subject><subject>Public Health Nursing</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>RESEARCH/RECHERCHE</subject><subject>Sample size</subject><subject>Schools</subject><subject>Students</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Swelling</subject><subject>Time Factors</subject><subject>Urban areas</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0008-4263</issn><issn>1920-7476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks-LEzEcxYMobl29eFeCsBdlNL8zc1G6xXWFlfVQvA5p5pua0ibdJOPif2-WKa2CpxC-H95737wg9JKS95QQ_eHyinBBuBb0EZrRjpFGC60eoxkhpG0EU_wMPct5U6-ca_4UndFWcMk7NkPb2wB4nnY4Jry8j5_wIgY7pgSh4Pmw88HnkkzxMeDo8DcIPqyjjdaaLV48wJtxbQpgEwZ8DftKFp_xJf5hrPUBMvYBf0_QFICQn6MnzmwzvDic52h59Xm5uG5ubr98XcxvGisYLY1T0CmnV0INSkqmbF1Sg9NdK9uBihacY5IBEZpQvSLOrpgd2GClloxazc_Rx0l2P652MNi6SzLbfp_8zqTffTS-_3cS_M9-HX_1qtOKcVoF3hwEUrwbIZd-E8cUauSecVbTTNDbCbIp5pzAHQ0o6R966U-9VPj135FO6KGIClwcAJPr27pkgvX5yFVTSZjoKvdu4nIdhTWkU7T_2r6a6E0uMR3VBO06Wf8C_wPowKvr</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Pielak, Karen L.</creator><creator>McIntyre, Cheryl C.</creator><creator>Remple, Valencia P.</creator><creator>Buxton, Jane A.</creator><creator>Skowronski, Danuta M.</creator><general>Canadian Public Health Association</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>4S-</scope><scope>4U-</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7T2</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88J</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DPSOV</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>KC-</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2L</scope><scope>M2O</scope><scope>M2R</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens</title><author>Pielak, Karen L. ; McIntyre, Cheryl C. ; Remple, Valencia P. ; Buxton, Jane A. ; Skowronski, Danuta M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-f6e96f7b46d65526c0077ef79858d148eff252e047017b0fcb2cd2dc57521c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Binomial distribution</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Clinical trials</topic><topic>Data analysis</topic><topic>Educational administration</topic><topic>Ethnicity</topic><topic>Health care administration</topic><topic>Health Surveys</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B vaccines</topic><topic>Hepatitis B Vaccines - administration & dosage</topic><topic>Hepatitis B Vaccines - adverse effects</topic><topic>Hepatitis B virus</topic><topic>Human bacterial diseases</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Programs</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningococcal Vaccines - administration & dosage</topic><topic>Meningococcal Vaccines - adverse effects</topic><topic>Miscellaneous</topic><topic>Nursing students</topic><topic>Parents & parenting</topic><topic>Public Health</topic><topic>Public Health Nursing</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>RESEARCH/RECHERCHE</topic><topic>Sample size</topic><topic>Schools</topic><topic>Students</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Swelling</topic><topic>Time Factors</topic><topic>Urban areas</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pielak, Karen L.</creatorcontrib><creatorcontrib>McIntyre, Cheryl C.</creatorcontrib><creatorcontrib>Remple, Valencia P.</creatorcontrib><creatorcontrib>Buxton, Jane A.</creatorcontrib><creatorcontrib>Skowronski, Danuta M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>BPIR.com Limited</collection><collection>University Readers</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Politics Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Politics Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Political Science Database</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pielak, Karen L.</au><au>McIntyre, Cheryl C.</au><au>Remple, Valencia P.</au><au>Buxton, Jane A.</au><au>Skowronski, Danuta M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens</atitle><jtitle>Canadian journal of public health</jtitle><stitle>Can J Public Health</stitle><addtitle>Can J Public Health</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>99</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>0008-4263</issn><eissn>1920-7476</eissn><coden>CJPEA4</coden><abstract><![CDATA[Background: The purpose of this study was to: a) compare rates of local reactions from meningococcal C conjugate (Neis Vac-C®) and hepatitis B vaccines (Recombivax HB®) , and b) compare local reactions when both injections were given in one arm versus one in each arm. Methods: Schools were randomized to have grade six students receive both vaccines in one arm (One Arm Group), or one vaccine in each arm (Two Arm Group; MCC always given in left arm). Structured telephone interviews of parents were conducted, and respondents were asked about local and systemic reactions, interference with school or other activities, need for medical attention, and lost parental work time. Findings: The Two Arm Group reported significantly more local redness >46 mm (6.5% vs. 0.5%, p<0.001), moderate to severe tenderness (28% vs. 18%, p<0.05), and drowsiness (14% vs. 7%, p<0.05). When adjusted for sex, ethnicity, and town of residence, report of any tenderness was associated with town of residence only; moderate or severe tenderness was independently associated with the Two Arm Group (OR 1.4, 95% CI 1.1-1.85). There were no statistically significant differences between groups for interference with school attendance or other activities, need for medical attention, or lost parental work time. Among participants of the Two Arm Group (188 students), there was more redness (6% vs. 2%, p<0.05) and tenderness (54% vs. 32%, p<0.001) experienced with Neis Vac-C® than with Recombivax HB®, respectively. Conclusions: Injecting two vaccines in one arm did not cause more local reaction than one injection in each arm and remains an option for those who prefer it for logistical reasons. If vaccinating in two arms, Neis Vac-C® should preferentially be given in the non-dominant arm. Contexte : Cette étude visait : a) à comparer les taux de réaction au point d'injection du vaccin conjugué contre le méningocoque du groupe C (Neis Vac-C®) et du vaccin contre l'hépatite B (Recombivax HB®) et b) à comparer les réactions au point d'injection lorsque les deux vaccins sont administrés dans le même bras ou un dans chaque bras. Méthode : Dans deux groupes d'écoles sélectionnées aléatoirement, des élèves de 6e année ont reçu les deux vaccins dans le même bras (groupe « un bras ») ou un vaccin dans chaque bras (groupe « deux bras »; le vaccin antiméningococcique était toujours administré dans le bras gauche). Des entrevues téléphoniques structurées ont été menées auprès des parents; les répondants ont été interrogés sur les réactions systémiques et au point d'injection, sur les conflits avec les activités scolaires ou autres, sur la nécessité de recevoir des soins médicaux et sur les heures de travail perdues par les parents. Résultats : Le groupe « deux bras » a déclaré une proportion significativement plus élevée de rougeur de la peau >46 mm au point d'injection (6,5 % c. 0,5 %, p<0,001), de sensibilité modérée à grave au toucher (28 % c. 18 %, p<0,05) et de somnolence (14 % c. 7 %, p<0,05). En rajustant les données selon le sexe, l'appartenance ethnique et la ville de résidence, les déclarations de sensibilité au toucher n'étaient plus associées qu'à la ville de résidence; une sensibilité modérée à grave était associée de façon indépendante au groupe « deux bras » (RC = 1,4; IC de 95 % = 1,1-1,85). Aucune différence significative n'a été observée entre les groupes pour ce qui est des conflits avec les activités scolaires ou autres, la nécessité de recevoir des soins médicaux ou les heures de travail perdues par les parents. Dans le groupe « deux bras » (188 élèves), on a observé davantage de rougeur (6 % c. 2 %, p<0,05) et de sensibilité au toucher (54 % c. 32 %, p<0,001), respectivement, avec le vaccin Neis Vac-C® qu'avec le Recombivax HB®. Conclusion : L'injection des deux vaccins dans le même bras n'a pas provoqué plus de réactions au point d'injection que la vaccination dans les deux bras; cela confirme que c'est une bonne option si on la préfère pour des raisons de logistique. Si l'on vaccine dans les deux bras, il est préférable d'administrer le Neis Vac-C® dans le bras non dominant.]]></abstract><cop>Cham</cop><pub>Canadian Public Health Association</pub><pmid>18435392</pmid><doi>10.1007/BF03403741</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-4263 |
| ispartof | Canadian journal of public health, 2008-01, Vol.99 (1), p.52-56 |
| issn | 0008-4263 1920-7476 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6976231 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Binomial distribution Biological and medical sciences Child Clinical trials Data analysis Educational administration Ethnicity Health care administration Health Surveys Hepatitis B - prevention & control Hepatitis B vaccines Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - adverse effects Hepatitis B virus Human bacterial diseases Human viral diseases Humans Immunization Immunization Programs Infectious diseases Medical sciences Medicine Medicine & Public Health Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - adverse effects Miscellaneous Nursing students Parents & parenting Public Health Public Health Nursing Public health. Hygiene Public health. Hygiene-occupational medicine RESEARCH/RECHERCHE Sample size Schools Students Studies Surveys and Questionnaires Swelling Time Factors Urban areas Vaccination Vaccines Viral diseases Viral hepatitis |
| title | One Arm or Two? Concurrent Administration of Meningococcal C Conjugate and Hepatitis B Vaccines in Pre-teens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A12%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=One%20Arm%20or%20Two?%20Concurrent%20Administration%20of%20Meningococcal%20C%20Conjugate%20and%20Hepatitis%20B%20Vaccines%20in%20Pre-teens&rft.jtitle=Canadian%20journal%20of%20public%20health&rft.au=Pielak,%20Karen%20L.&rft.date=2008-01-01&rft.volume=99&rft.issue=1&rft.spage=52&rft.epage=56&rft.pages=52-56&rft.issn=0008-4263&rft.eissn=1920-7476&rft.coden=CJPEA4&rft_id=info:doi/10.1007/BF03403741&rft_dat=%3Cjstor_pubme%3E41995033%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=232007231&rft_id=info:pmid/18435392&rft_jstor_id=41995033&rfr_iscdi=true |