Association between fetal sex, birthweight percentile and adverse pregnancy outcome
Introduction The objective was to evaluate the association between fetal sex and adverse pregnancy outcome, while correcting for fetal growth and gestational age at delivery. Material and methods Data from the Netherlands Perinatal Registry (1999‐2010) were used. The study population comprised all w...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2020-01, Vol.99 (1), p.48-58 |
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| creator | Voskamp, Bart Jan Peelen, Myrthe J. C. S. Ravelli, Anita C. J. Lee, Robin Mol, Ben W. J. Pajkrt, Eva Ganzevoort, Wessel Kazemier, Brenda M. |
| description | Introduction
The objective was to evaluate the association between fetal sex and adverse pregnancy outcome, while correcting for fetal growth and gestational age at delivery.
Material and methods
Data from the Netherlands Perinatal Registry (1999‐2010) were used. The study population comprised all white European women with a singleton delivery between 25+0 and 42+6 weeks of gestation. Fetuses with structural or chromosomal abnormalities were excluded. Outcomes were antepartum death, intrapartum/neonatal death (from onset of labor until 28 days after birth), perinatal death (antepartum death or intrapartum/neonatal death), a composite of neonatal morbidity (including infant respiratory distress syndrome, sepsis, necrotizing enterocolitis, meconium aspiration, persistent pulmonary hypertension of the newborn, periventricular leukomalacia, Apgar score |
| doi_str_mv | 10.1111/aogs.13709 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6973256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2330711251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4489-72476aa038271c813b2b21d9b865d42fdcfa6a39a23d2418afc2c835fbbb3c993</originalsourceid><addsrcrecordid>eNp9kc1qGzEUhUVIaZy0mzxAEWRTQibV38xIm4IJ-SkEski7FpLmjq0wllxpJq7fvnKdhraLanMR9-PjSAehU0ouaTmfTFzkS8pbog7QjDaEVERQdohmhBBaNVyoI3Sc81O5sVbIt-iIU8EEkfUMPc5zjs6b0ceALYwbgIB7GM2AM_y4wNancbkBv1iOeA3JQRj9ANiEDpvuGVIGvE6wCCa4LY7T6OIK3qE3vRkyvH-ZJ-jbzfXXq7vq_uH2y9X8vnJCSFW1TLSNMYRL1lInKbfMMtopK5u6E6zvXG8aw5VhvGOCStM75iSve2std0rxE_R5711PdgXdLlsyg14nvzJpq6Px-u9N8Eu9iM-6US1ndVMEH18EKX6fII965bODYTAB4pQ1Y22tRMOlLOjZP-hTnFIoz9OMc9JSympaqPM95VLMOUH_GoYSvetK77rSv7oq8Ic_47-iv8spAN0Dm_Ll2_-o9Pzh9nEv_QkWcaBA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2330711251</pqid></control><display><type>article</type><title>Association between fetal sex, birthweight percentile and adverse pregnancy outcome</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Voskamp, Bart Jan ; Peelen, Myrthe J. C. S. ; Ravelli, Anita C. J. ; Lee, Robin ; Mol, Ben W. J. ; Pajkrt, Eva ; Ganzevoort, Wessel ; Kazemier, Brenda M.</creator><creatorcontrib>Voskamp, Bart Jan ; Peelen, Myrthe J. C. S. ; Ravelli, Anita C. J. ; Lee, Robin ; Mol, Ben W. J. ; Pajkrt, Eva ; Ganzevoort, Wessel ; Kazemier, Brenda M.</creatorcontrib><description>Introduction
The objective was to evaluate the association between fetal sex and adverse pregnancy outcome, while correcting for fetal growth and gestational age at delivery.
Material and methods
Data from the Netherlands Perinatal Registry (1999‐2010) were used. The study population comprised all white European women with a singleton delivery between 25+0 and 42+6 weeks of gestation. Fetuses with structural or chromosomal abnormalities were excluded. Outcomes were antepartum death, intrapartum/neonatal death (from onset of labor until 28 days after birth), perinatal death (antepartum death or intrapartum/neonatal death), a composite of neonatal morbidity (including infant respiratory distress syndrome, sepsis, necrotizing enterocolitis, meconium aspiration, persistent pulmonary hypertension of the newborn, periventricular leukomalacia, Apgar score <7 at 5 minutes, and intracranial hemorrhage) and a composite adverse neonatal outcome (perinatal death or neonatal morbidity). Outcomes were expressed stratified by birthweight percentile (<p10 [small for gestation], p10‐90 [normal weight], >p90 [large for gestation]) and gestational age at delivery (25+0‐27+6, 28+0‐31+6, 32+0‐36+6, 37+0‐42+6 weeks). The association between fetal sex and outcome was assessed using the fetus at risk approach.
Results
We studied 1 742 831 pregnant women. We found no increased risk of antepartum, intrapartum/neonatal and perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks compared with females. We found an increased risk of antepartum death among small‐for‐gestation males born after 28+0 weeks (relative risk [RR] 1.16‐1.40). All males born after 32+0 weeks of gestation suffered more neonatal morbidity than females regardless of birthweight percentile (RR 1.07‐1.34). Infant respiratory distress syndrome, sepsis, persistent pulmonary hypertension of the newborn, Apgar score <7 at 5 minutes, and intracranial hemorrhage all occurred more often in males than in females.
Conclusions
Small‐for‐gestation males have an increased risk of antepartum death and all males born after 32+0 weeks of gestation have an increased risk of neonatal morbidity compared with females. In contrast to findings in previous studies we found no increased risk of antepartum, intrapartum/neonatal or perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1111/aogs.13709</identifier><identifier>PMID: 31424085</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; adverse outcome ; antepartum death ; Apgar Score ; Birth Weight ; Childbirth & labor ; Clinical outcomes ; Female ; Health risk assessment ; Hemorrhage ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Infant, Newborn, Diseases - epidemiology ; intrapartum death ; Male ; Morbidity ; neonatal death ; Netherlands - epidemiology ; Newborn babies ; Original ; Perinatal Death ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pulmonary hypertension ; Registries ; Respiratory distress syndrome ; Risk Factors ; Sepsis ; sex ; Sex Factors ; small for gestational age</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2020-01, Vol.99 (1), p.48-58</ispartof><rights>2019 The Authors. published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)</rights><rights>2019 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).</rights><rights>Copyright © 2020 Acta Obstetricia et Gynecologica Scandinavica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4489-72476aa038271c813b2b21d9b865d42fdcfa6a39a23d2418afc2c835fbbb3c993</citedby><cites>FETCH-LOGICAL-c4489-72476aa038271c813b2b21d9b865d42fdcfa6a39a23d2418afc2c835fbbb3c993</cites><orcidid>0000-0002-1281-0911 ; 0000-0002-9735-3747</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faogs.13709$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faogs.13709$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31424085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voskamp, Bart Jan</creatorcontrib><creatorcontrib>Peelen, Myrthe J. C. S.</creatorcontrib><creatorcontrib>Ravelli, Anita C. J.</creatorcontrib><creatorcontrib>Lee, Robin</creatorcontrib><creatorcontrib>Mol, Ben W. J.</creatorcontrib><creatorcontrib>Pajkrt, Eva</creatorcontrib><creatorcontrib>Ganzevoort, Wessel</creatorcontrib><creatorcontrib>Kazemier, Brenda M.</creatorcontrib><title>Association between fetal sex, birthweight percentile and adverse pregnancy outcome</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Introduction
The objective was to evaluate the association between fetal sex and adverse pregnancy outcome, while correcting for fetal growth and gestational age at delivery.
Material and methods
Data from the Netherlands Perinatal Registry (1999‐2010) were used. The study population comprised all white European women with a singleton delivery between 25+0 and 42+6 weeks of gestation. Fetuses with structural or chromosomal abnormalities were excluded. Outcomes were antepartum death, intrapartum/neonatal death (from onset of labor until 28 days after birth), perinatal death (antepartum death or intrapartum/neonatal death), a composite of neonatal morbidity (including infant respiratory distress syndrome, sepsis, necrotizing enterocolitis, meconium aspiration, persistent pulmonary hypertension of the newborn, periventricular leukomalacia, Apgar score <7 at 5 minutes, and intracranial hemorrhage) and a composite adverse neonatal outcome (perinatal death or neonatal morbidity). Outcomes were expressed stratified by birthweight percentile (<p10 [small for gestation], p10‐90 [normal weight], >p90 [large for gestation]) and gestational age at delivery (25+0‐27+6, 28+0‐31+6, 32+0‐36+6, 37+0‐42+6 weeks). The association between fetal sex and outcome was assessed using the fetus at risk approach.
Results
We studied 1 742 831 pregnant women. We found no increased risk of antepartum, intrapartum/neonatal and perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks compared with females. We found an increased risk of antepartum death among small‐for‐gestation males born after 28+0 weeks (relative risk [RR] 1.16‐1.40). All males born after 32+0 weeks of gestation suffered more neonatal morbidity than females regardless of birthweight percentile (RR 1.07‐1.34). Infant respiratory distress syndrome, sepsis, persistent pulmonary hypertension of the newborn, Apgar score <7 at 5 minutes, and intracranial hemorrhage all occurred more often in males than in females.
Conclusions
Small‐for‐gestation males have an increased risk of antepartum death and all males born after 32+0 weeks of gestation have an increased risk of neonatal morbidity compared with females. In contrast to findings in previous studies we found no increased risk of antepartum, intrapartum/neonatal or perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks.</description><subject>Adult</subject><subject>adverse outcome</subject><subject>antepartum death</subject><subject>Apgar Score</subject><subject>Birth Weight</subject><subject>Childbirth & labor</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - epidemiology</subject><subject>intrapartum death</subject><subject>Male</subject><subject>Morbidity</subject><subject>neonatal death</subject><subject>Netherlands - epidemiology</subject><subject>Newborn babies</subject><subject>Original</subject><subject>Perinatal Death</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pulmonary hypertension</subject><subject>Registries</subject><subject>Respiratory distress syndrome</subject><subject>Risk Factors</subject><subject>Sepsis</subject><subject>sex</subject><subject>Sex Factors</subject><subject>small for gestational age</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1qGzEUhUVIaZy0mzxAEWRTQibV38xIm4IJ-SkEski7FpLmjq0wllxpJq7fvnKdhraLanMR9-PjSAehU0ouaTmfTFzkS8pbog7QjDaEVERQdohmhBBaNVyoI3Sc81O5sVbIt-iIU8EEkfUMPc5zjs6b0ceALYwbgIB7GM2AM_y4wNancbkBv1iOeA3JQRj9ANiEDpvuGVIGvE6wCCa4LY7T6OIK3qE3vRkyvH-ZJ-jbzfXXq7vq_uH2y9X8vnJCSFW1TLSNMYRL1lInKbfMMtopK5u6E6zvXG8aw5VhvGOCStM75iSve2std0rxE_R5711PdgXdLlsyg14nvzJpq6Px-u9N8Eu9iM-6US1ndVMEH18EKX6fII965bODYTAB4pQ1Y22tRMOlLOjZP-hTnFIoz9OMc9JSympaqPM95VLMOUH_GoYSvetK77rSv7oq8Ic_47-iv8spAN0Dm_Ll2_-o9Pzh9nEv_QkWcaBA</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Voskamp, Bart Jan</creator><creator>Peelen, Myrthe J. C. S.</creator><creator>Ravelli, Anita C. J.</creator><creator>Lee, Robin</creator><creator>Mol, Ben W. J.</creator><creator>Pajkrt, Eva</creator><creator>Ganzevoort, Wessel</creator><creator>Kazemier, Brenda M.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1281-0911</orcidid><orcidid>https://orcid.org/0000-0002-9735-3747</orcidid></search><sort><creationdate>202001</creationdate><title>Association between fetal sex, birthweight percentile and adverse pregnancy outcome</title><author>Voskamp, Bart Jan ; Peelen, Myrthe J. C. S. ; Ravelli, Anita C. J. ; Lee, Robin ; Mol, Ben W. J. ; Pajkrt, Eva ; Ganzevoort, Wessel ; Kazemier, Brenda M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4489-72476aa038271c813b2b21d9b865d42fdcfa6a39a23d2418afc2c835fbbb3c993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>adverse outcome</topic><topic>antepartum death</topic><topic>Apgar Score</topic><topic>Birth Weight</topic><topic>Childbirth & labor</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - epidemiology</topic><topic>intrapartum death</topic><topic>Male</topic><topic>Morbidity</topic><topic>neonatal death</topic><topic>Netherlands - epidemiology</topic><topic>Newborn babies</topic><topic>Original</topic><topic>Perinatal Death</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pulmonary hypertension</topic><topic>Registries</topic><topic>Respiratory distress syndrome</topic><topic>Risk Factors</topic><topic>Sepsis</topic><topic>sex</topic><topic>Sex Factors</topic><topic>small for gestational age</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voskamp, Bart Jan</creatorcontrib><creatorcontrib>Peelen, Myrthe J. C. S.</creatorcontrib><creatorcontrib>Ravelli, Anita C. J.</creatorcontrib><creatorcontrib>Lee, Robin</creatorcontrib><creatorcontrib>Mol, Ben W. J.</creatorcontrib><creatorcontrib>Pajkrt, Eva</creatorcontrib><creatorcontrib>Ganzevoort, Wessel</creatorcontrib><creatorcontrib>Kazemier, Brenda M.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voskamp, Bart Jan</au><au>Peelen, Myrthe J. C. S.</au><au>Ravelli, Anita C. J.</au><au>Lee, Robin</au><au>Mol, Ben W. J.</au><au>Pajkrt, Eva</au><au>Ganzevoort, Wessel</au><au>Kazemier, Brenda M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between fetal sex, birthweight percentile and adverse pregnancy outcome</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2020-01</date><risdate>2020</risdate><volume>99</volume><issue>1</issue><spage>48</spage><epage>58</epage><pages>48-58</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><abstract>Introduction
The objective was to evaluate the association between fetal sex and adverse pregnancy outcome, while correcting for fetal growth and gestational age at delivery.
Material and methods
Data from the Netherlands Perinatal Registry (1999‐2010) were used. The study population comprised all white European women with a singleton delivery between 25+0 and 42+6 weeks of gestation. Fetuses with structural or chromosomal abnormalities were excluded. Outcomes were antepartum death, intrapartum/neonatal death (from onset of labor until 28 days after birth), perinatal death (antepartum death or intrapartum/neonatal death), a composite of neonatal morbidity (including infant respiratory distress syndrome, sepsis, necrotizing enterocolitis, meconium aspiration, persistent pulmonary hypertension of the newborn, periventricular leukomalacia, Apgar score <7 at 5 minutes, and intracranial hemorrhage) and a composite adverse neonatal outcome (perinatal death or neonatal morbidity). Outcomes were expressed stratified by birthweight percentile (<p10 [small for gestation], p10‐90 [normal weight], >p90 [large for gestation]) and gestational age at delivery (25+0‐27+6, 28+0‐31+6, 32+0‐36+6, 37+0‐42+6 weeks). The association between fetal sex and outcome was assessed using the fetus at risk approach.
Results
We studied 1 742 831 pregnant women. We found no increased risk of antepartum, intrapartum/neonatal and perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks compared with females. We found an increased risk of antepartum death among small‐for‐gestation males born after 28+0 weeks (relative risk [RR] 1.16‐1.40). All males born after 32+0 weeks of gestation suffered more neonatal morbidity than females regardless of birthweight percentile (RR 1.07‐1.34). Infant respiratory distress syndrome, sepsis, persistent pulmonary hypertension of the newborn, Apgar score <7 at 5 minutes, and intracranial hemorrhage all occurred more often in males than in females.
Conclusions
Small‐for‐gestation males have an increased risk of antepartum death and all males born after 32+0 weeks of gestation have an increased risk of neonatal morbidity compared with females. In contrast to findings in previous studies we found no increased risk of antepartum, intrapartum/neonatal or perinatal death in normal weight and large‐for‐gestation males born after 28+0 weeks.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>31424085</pmid><doi>10.1111/aogs.13709</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1281-0911</orcidid><orcidid>https://orcid.org/0000-0002-9735-3747</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adverse outcome antepartum death Apgar Score Birth Weight Childbirth & labor Clinical outcomes Female Health risk assessment Hemorrhage Humans Infant Infant Mortality Infant, Newborn Infant, Newborn, Diseases - epidemiology intrapartum death Male Morbidity neonatal death Netherlands - epidemiology Newborn babies Original Perinatal Death Pregnancy Pregnancy Outcome - epidemiology Pulmonary hypertension Registries Respiratory distress syndrome Risk Factors Sepsis sex Sex Factors small for gestational age |
| title | Association between fetal sex, birthweight percentile and adverse pregnancy outcome |
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