Inherited MC1R variants in patients with melanoma are associated with better survival in women
Summary Background Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown. Objectives To evaluate the relationship between germline MC1R status and surv...
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| Veröffentlicht in: | British journal of dermatology (1951) 2020-01, Vol.182 (1), p.138-146 |
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| creator | Lira, F.E. Podlipnik, S. Potrony, M. Tell‐Martí, G. Calbet‐Llopart, N. Barreiro, A. Carrera, C. Malvehy, J. Puig, S. |
| description | Summary
Background
Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown.
Objectives
To evaluate the relationship between germline MC1R status and survival, and determine any association with sex.
Methods
This was a cohort study including 1341 patients with melanoma from the Melanoma Unit of the Hospital Clinic of Barcelona, between January 1996 and April 2018. We examined known sex‐related prognosis factors as they relate to features of melanoma and evaluated the sex‐specific role of MC1R in overall and melanoma‐specific survival. Hazard ratios (HRs) were calculated using univariate and multivariate Cox logistic regression.
Results
Men showed lower overall survival than women (P < 0·001) and the presence of inherited MC1R variants was not associated with better survival in our cohort. However, in women the presence of MC1R variants was associated with better overall survival in the multivariate analysis [HR 0·57, 95% confidence interval (CI) 0·38–0·85; P = 0·006] but not in men [HR 1·26, 95% CI 0·89–1·79; P = 0·185 (P‐value for interaction 0·004)]. Analysis performed for melanoma‐specific survival showed the same level of significance.
Conclusions
Inherited MC1R variants are associated with improved overall survival in women with melanoma but not in men. Intrinsic sex‐dependent features can modify the role of specific genes in melanoma prognosis. We believe that survival studies of patients with melanoma should include analysis by sex and MC1R genotype.
What's already known about this topic?
Inherited MC1R variants have been associated with a better melanoma prognosis, but their interaction with sex is unknown.
What does this study add?
MC1R variants are related to better overall survival and melanoma‐specific survival in women but not in men.
What is the translational message?
These differences between the sexes could imply future changes in melanoma follow‐up and treatment strategies.
This provides a basis for understanding the interaction between sex‐related genes and germline variants in cancer.
Respond to this article
Linked Editorial: Craig and Virós. Br J Dermatol 2020; 182:5–6. |
| doi_str_mv | 10.1111/bjd.18024 |
| format | Article |
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Background
Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown.
Objectives
To evaluate the relationship between germline MC1R status and survival, and determine any association with sex.
Methods
This was a cohort study including 1341 patients with melanoma from the Melanoma Unit of the Hospital Clinic of Barcelona, between January 1996 and April 2018. We examined known sex‐related prognosis factors as they relate to features of melanoma and evaluated the sex‐specific role of MC1R in overall and melanoma‐specific survival. Hazard ratios (HRs) were calculated using univariate and multivariate Cox logistic regression.
Results
Men showed lower overall survival than women (P < 0·001) and the presence of inherited MC1R variants was not associated with better survival in our cohort. However, in women the presence of MC1R variants was associated with better overall survival in the multivariate analysis [HR 0·57, 95% confidence interval (CI) 0·38–0·85; P = 0·006] but not in men [HR 1·26, 95% CI 0·89–1·79; P = 0·185 (P‐value for interaction 0·004)]. Analysis performed for melanoma‐specific survival showed the same level of significance.
Conclusions
Inherited MC1R variants are associated with improved overall survival in women with melanoma but not in men. Intrinsic sex‐dependent features can modify the role of specific genes in melanoma prognosis. We believe that survival studies of patients with melanoma should include analysis by sex and MC1R genotype.
What's already known about this topic?
Inherited MC1R variants have been associated with a better melanoma prognosis, but their interaction with sex is unknown.
What does this study add?
MC1R variants are related to better overall survival and melanoma‐specific survival in women but not in men.
What is the translational message?
These differences between the sexes could imply future changes in melanoma follow‐up and treatment strategies.
This provides a basis for understanding the interaction between sex‐related genes and germline variants in cancer.
Respond to this article
Linked Editorial: Craig and Virós. Br J Dermatol 2020; 182:5–6.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.18024</identifier><identifier>PMID: 31016712</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Cohort Studies ; Female ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Humans ; Male ; Medical prognosis ; Melanoma ; Melanoma - genetics ; Multivariate analysis ; Original ; Patients ; Prognosis ; Receptor, Melanocortin, Type 1 - genetics ; Sex ; Skin Neoplasms - genetics ; Survival ; Translational Research</subject><ispartof>British journal of dermatology (1951), 2020-01, Vol.182 (1), p.138-146</ispartof><rights>2019 The Authors. published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.</rights><rights>2019 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.</rights><rights>2019. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4150-0522 ; 0000-0003-1608-8820 ; 0000-0003-2766-0765 ; 0000-0002-3387-3444 ; 0000-0003-1337-9745</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.18024$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.18024$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31016712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lira, F.E.</creatorcontrib><creatorcontrib>Podlipnik, S.</creatorcontrib><creatorcontrib>Potrony, M.</creatorcontrib><creatorcontrib>Tell‐Martí, G.</creatorcontrib><creatorcontrib>Calbet‐Llopart, N.</creatorcontrib><creatorcontrib>Barreiro, A.</creatorcontrib><creatorcontrib>Carrera, C.</creatorcontrib><creatorcontrib>Malvehy, J.</creatorcontrib><creatorcontrib>Puig, S.</creatorcontrib><title>Inherited MC1R variants in patients with melanoma are associated with better survival in women</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background
Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown.
Objectives
To evaluate the relationship between germline MC1R status and survival, and determine any association with sex.
Methods
This was a cohort study including 1341 patients with melanoma from the Melanoma Unit of the Hospital Clinic of Barcelona, between January 1996 and April 2018. We examined known sex‐related prognosis factors as they relate to features of melanoma and evaluated the sex‐specific role of MC1R in overall and melanoma‐specific survival. Hazard ratios (HRs) were calculated using univariate and multivariate Cox logistic regression.
Results
Men showed lower overall survival than women (P < 0·001) and the presence of inherited MC1R variants was not associated with better survival in our cohort. However, in women the presence of MC1R variants was associated with better overall survival in the multivariate analysis [HR 0·57, 95% confidence interval (CI) 0·38–0·85; P = 0·006] but not in men [HR 1·26, 95% CI 0·89–1·79; P = 0·185 (P‐value for interaction 0·004)]. Analysis performed for melanoma‐specific survival showed the same level of significance.
Conclusions
Inherited MC1R variants are associated with improved overall survival in women with melanoma but not in men. Intrinsic sex‐dependent features can modify the role of specific genes in melanoma prognosis. We believe that survival studies of patients with melanoma should include analysis by sex and MC1R genotype.
What's already known about this topic?
Inherited MC1R variants have been associated with a better melanoma prognosis, but their interaction with sex is unknown.
What does this study add?
MC1R variants are related to better overall survival and melanoma‐specific survival in women but not in men.
What is the translational message?
These differences between the sexes could imply future changes in melanoma follow‐up and treatment strategies.
This provides a basis for understanding the interaction between sex‐related genes and germline variants in cancer.
Respond to this article
Linked Editorial: Craig and Virós. Br J Dermatol 2020; 182:5–6.</description><subject>Cohort Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Melanoma - genetics</subject><subject>Multivariate analysis</subject><subject>Original</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Receptor, Melanocortin, Type 1 - genetics</subject><subject>Sex</subject><subject>Skin Neoplasms - genetics</subject><subject>Survival</subject><subject>Translational Research</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpdUU1v1DAQtRCILoUDfwBF4sIlre1x4viCBMtXURESgivW2JmyXuVjaye76r_H2ZYKmMuM9N48vZnH2HPBz0Suc7dtz0TDpXrAVgLqqpQC4CFbcc51yU0NJ-xJSlvOBfCKP2YnILiotZAr9vNi2FAME7XFl7X4VuwxBhymVISh2OEUaJkPYdoUPXU4jD0WGKnAlEYfcFk7go6miWKR5rgPe-yW7cPY0_CUPbrCLtGzu37Kfnx4_339qbz8-vFi_eay3AEoVTrtTeUk1h6oMh586zyiUY5qRY24UugbWYHjgASuarWAFoQyxmltFHA4Za9vdXez66n12XbEzu5i6DHe2BGD_RcZwsb-Gve2Nhp4o7PAqzuBOF7PlCbbh-SpyzfTOCcr80sNQAML9eV_1O04xyGfZyWA0LIxSmbWi78d3Vv58_pMOL8lHEJHN_e44HbJ1OZM7TFT-_bzu-MAvwFXeJRZ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Lira, F.E.</creator><creator>Podlipnik, S.</creator><creator>Potrony, M.</creator><creator>Tell‐Martí, G.</creator><creator>Calbet‐Llopart, N.</creator><creator>Barreiro, A.</creator><creator>Carrera, C.</creator><creator>Malvehy, J.</creator><creator>Puig, S.</creator><general>Oxford University Press</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4150-0522</orcidid><orcidid>https://orcid.org/0000-0003-1608-8820</orcidid><orcidid>https://orcid.org/0000-0003-2766-0765</orcidid><orcidid>https://orcid.org/0000-0002-3387-3444</orcidid><orcidid>https://orcid.org/0000-0003-1337-9745</orcidid></search><sort><creationdate>202001</creationdate><title>Inherited MC1R variants in patients with melanoma are associated with better survival in women</title><author>Lira, F.E. ; Podlipnik, S. ; Potrony, M. ; Tell‐Martí, G. ; Calbet‐Llopart, N. ; Barreiro, A. ; Carrera, C. ; Malvehy, J. ; Puig, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3344-b7c95b2a6c3e59c3cdbcaa94be64e81f4ac8253b03ae3b5d713d31499b7794303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cohort Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Melanoma - genetics</topic><topic>Multivariate analysis</topic><topic>Original</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Receptor, Melanocortin, Type 1 - genetics</topic><topic>Sex</topic><topic>Skin Neoplasms - genetics</topic><topic>Survival</topic><topic>Translational Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lira, F.E.</creatorcontrib><creatorcontrib>Podlipnik, S.</creatorcontrib><creatorcontrib>Potrony, M.</creatorcontrib><creatorcontrib>Tell‐Martí, G.</creatorcontrib><creatorcontrib>Calbet‐Llopart, N.</creatorcontrib><creatorcontrib>Barreiro, A.</creatorcontrib><creatorcontrib>Carrera, C.</creatorcontrib><creatorcontrib>Malvehy, J.</creatorcontrib><creatorcontrib>Puig, S.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lira, F.E.</au><au>Podlipnik, S.</au><au>Potrony, M.</au><au>Tell‐Martí, G.</au><au>Calbet‐Llopart, N.</au><au>Barreiro, A.</au><au>Carrera, C.</au><au>Malvehy, J.</au><au>Puig, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inherited MC1R variants in patients with melanoma are associated with better survival in women</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>182</volume><issue>1</issue><spage>138</spage><epage>146</epage><pages>138-146</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background
Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown.
Objectives
To evaluate the relationship between germline MC1R status and survival, and determine any association with sex.
Methods
This was a cohort study including 1341 patients with melanoma from the Melanoma Unit of the Hospital Clinic of Barcelona, between January 1996 and April 2018. We examined known sex‐related prognosis factors as they relate to features of melanoma and evaluated the sex‐specific role of MC1R in overall and melanoma‐specific survival. Hazard ratios (HRs) were calculated using univariate and multivariate Cox logistic regression.
Results
Men showed lower overall survival than women (P < 0·001) and the presence of inherited MC1R variants was not associated with better survival in our cohort. However, in women the presence of MC1R variants was associated with better overall survival in the multivariate analysis [HR 0·57, 95% confidence interval (CI) 0·38–0·85; P = 0·006] but not in men [HR 1·26, 95% CI 0·89–1·79; P = 0·185 (P‐value for interaction 0·004)]. Analysis performed for melanoma‐specific survival showed the same level of significance.
Conclusions
Inherited MC1R variants are associated with improved overall survival in women with melanoma but not in men. Intrinsic sex‐dependent features can modify the role of specific genes in melanoma prognosis. We believe that survival studies of patients with melanoma should include analysis by sex and MC1R genotype.
What's already known about this topic?
Inherited MC1R variants have been associated with a better melanoma prognosis, but their interaction with sex is unknown.
What does this study add?
MC1R variants are related to better overall survival and melanoma‐specific survival in women but not in men.
What is the translational message?
These differences between the sexes could imply future changes in melanoma follow‐up and treatment strategies.
This provides a basis for understanding the interaction between sex‐related genes and germline variants in cancer.
Respond to this article
Linked Editorial: Craig and Virós. Br J Dermatol 2020; 182:5–6.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31016712</pmid><doi>10.1111/bjd.18024</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4150-0522</orcidid><orcidid>https://orcid.org/0000-0003-1608-8820</orcidid><orcidid>https://orcid.org/0000-0003-2766-0765</orcidid><orcidid>https://orcid.org/0000-0002-3387-3444</orcidid><orcidid>https://orcid.org/0000-0003-1337-9745</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of dermatology (1951), 2020-01, Vol.182 (1), p.138-146 |
| issn | 0007-0963 1365-2133 |
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| source | MEDLINE; Wiley Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Cohort Studies Female Genetic Predisposition to Disease Genotype Genotypes Humans Male Medical prognosis Melanoma Melanoma - genetics Multivariate analysis Original Patients Prognosis Receptor, Melanocortin, Type 1 - genetics Sex Skin Neoplasms - genetics Survival Translational Research |
| title | Inherited MC1R variants in patients with melanoma are associated with better survival in women |
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