Extensive Structure–Activity Relationship Study of Albicidin's C‐Terminal Dipeptidic p‐Aminobenzoic Acid Moiety

Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug. Hence, structure–activity relationship studies are key for the in‐d...

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Veröffentlicht in:	Chemistry : a European journal 2019-12, Vol.25 (72), p.16538-16543
Hauptverfasser:	Behroz, Iraj, Durkin, Patrick, Grätz, Stefan, Seidel, Maria, Rostock, Lida, Spinczyk, Marcello, Weston, John B., Süssmuth, Roderich D.
Format:	Artikel
Sprache:	eng
Schlagworte:	albicidin Amino acids Antibacterial activity antibiotics Chemistry Communication Communications DNA topoisomerase drug discovery Gram-negative bacteria Klebsiella Natural products structure–activity relationships Triazoles
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