MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES
Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyr...
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| Veröffentlicht in: | Acta clinica Croatica (Tisak) 2019-09, Vol.58 (3), p.417-420 |
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| container_title | Acta clinica Croatica (Tisak) |
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| creator | Sit, Mustafa Aktas, Gulali Ozer, Bahri Kocak, Mehmet Zahid Erkus, Edip Erkol, Hayri Yaman, Semih Savli, Haluk |
| description | Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid nodules after precise pathologic diagnosis. We retrospectively analyzed hemograms of patients having undergone thyroid surgery for thyroid nodule between January 2013 and January 2015, and compared them to those recorded in healthy subjects. MPV was higher in the malignant thyroid nodule group than in the benign nodule group (9.1±1 fL
. 7.8±0.8 fL). The difference was statistically significant (p |
| doi_str_mv | 10.20471/acc.2019.58.03.03 |
| format | Article |
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. 7.8±0.8 fL). The difference was statistically significant (p<0.001). Increased MPV should be considered as an assistive diagnostic tool in differentiating malignant and benign thyroid nodules. However, further prospective studies are required to confirm its usefulness in this population.</description><identifier>ISSN: 0353-9466</identifier><identifier>EISSN: 1333-9451</identifier><identifier>DOI: 10.20471/acc.2019.58.03.03</identifier><identifier>PMID: 31969752</identifier><language>eng</language><publisher>Croatia: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb</publisher><subject>Correlation of Data ; Diagnosis, Differential ; Early Detection of Cancer - methods ; Female ; Humans ; Male ; Mean Platelet Volume - methods ; Middle Aged ; Original Scientific Papers ; Reproducibility of Results ; Retrospective Studies ; Thyroid Neoplasms - blood ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroid Nodule - blood ; Thyroid Nodule - diagnosis ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery ; Thyroidectomy - methods ; Thyroidectomy - statistics & numerical data</subject><ispartof>Acta clinica Croatica (Tisak), 2019-09, Vol.58 (3), p.417-420</ispartof><rights>2019 Sestre Milosrdnice University Hospital</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5de255b762145a051127ac874fe75269eb4799c75d28b35079e3a1194cdf889f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971808/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971808/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31969752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sit, Mustafa</creatorcontrib><creatorcontrib>Aktas, Gulali</creatorcontrib><creatorcontrib>Ozer, Bahri</creatorcontrib><creatorcontrib>Kocak, Mehmet Zahid</creatorcontrib><creatorcontrib>Erkus, Edip</creatorcontrib><creatorcontrib>Erkol, Hayri</creatorcontrib><creatorcontrib>Yaman, Semih</creatorcontrib><creatorcontrib>Savli, Haluk</creatorcontrib><title>MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES</title><title>Acta clinica Croatica (Tisak)</title><addtitle>Acta Clin Croat</addtitle><description>Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid nodules after precise pathologic diagnosis. We retrospectively analyzed hemograms of patients having undergone thyroid surgery for thyroid nodule between January 2013 and January 2015, and compared them to those recorded in healthy subjects. MPV was higher in the malignant thyroid nodule group than in the benign nodule group (9.1±1 fL
. 7.8±0.8 fL). The difference was statistically significant (p<0.001). Increased MPV should be considered as an assistive diagnostic tool in differentiating malignant and benign thyroid nodules. However, further prospective studies are required to confirm its usefulness in this population.</description><subject>Correlation of Data</subject><subject>Diagnosis, Differential</subject><subject>Early Detection of Cancer - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mean Platelet Volume - methods</subject><subject>Middle Aged</subject><subject>Original Scientific Papers</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid Nodule - blood</subject><subject>Thyroid Nodule - diagnosis</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><subject>Thyroidectomy - methods</subject><subject>Thyroidectomy - statistics & numerical data</subject><issn>0353-9466</issn><issn>1333-9451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUVtPwjAUboxGEP0DPpg9-gL2urU-mCysXGJhBgeJT00pnWKA4QYm_nuLINHkJOf-ncsHwDWCLQxphO6Mtd5CosV4CxIvJ6COCCFNQRk6BXVI2M4Owxq4qKp36H3E2DmoESRCETFcB92BjIfBk4ozqWQWTFI1Hsj7wMfSiRypNH2USdCTo1glQdoJBrHqd4fxMAuy3sso7SfBME3GSj5fgrPcLCp3ddANMO7IrN1rqrTbb8eqaSnEmyabOczYNAoxosxAhhCOjOURzZ1fJxRuSiMhbMRmmE8Jg5FwxCAkqJ3lnIucNMDDHne9nS7dzLrVpjQLvS7nS1N-6cLM9f_Mav6mX4tP7e9FHHIPcHsAKIuPras2ejmvrFsszMoV20pjQinGAnPkS_G-1JZFVZUuP45BUP8woD0DeseAZlxD4sU33fxd8Njy-3LyDbsXez0</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Sit, Mustafa</creator><creator>Aktas, Gulali</creator><creator>Ozer, Bahri</creator><creator>Kocak, Mehmet Zahid</creator><creator>Erkus, Edip</creator><creator>Erkol, Hayri</creator><creator>Yaman, Semih</creator><creator>Savli, Haluk</creator><general>Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES</title><author>Sit, Mustafa ; Aktas, Gulali ; Ozer, Bahri ; Kocak, Mehmet Zahid ; Erkus, Edip ; Erkol, Hayri ; Yaman, Semih ; Savli, Haluk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5de255b762145a051127ac874fe75269eb4799c75d28b35079e3a1194cdf889f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Correlation of Data</topic><topic>Diagnosis, Differential</topic><topic>Early Detection of Cancer - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mean Platelet Volume - methods</topic><topic>Middle Aged</topic><topic>Original Scientific Papers</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid Nodule - blood</topic><topic>Thyroid Nodule - diagnosis</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><topic>Thyroidectomy - methods</topic><topic>Thyroidectomy - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sit, Mustafa</creatorcontrib><creatorcontrib>Aktas, Gulali</creatorcontrib><creatorcontrib>Ozer, Bahri</creatorcontrib><creatorcontrib>Kocak, Mehmet Zahid</creatorcontrib><creatorcontrib>Erkus, Edip</creatorcontrib><creatorcontrib>Erkol, Hayri</creatorcontrib><creatorcontrib>Yaman, Semih</creatorcontrib><creatorcontrib>Savli, Haluk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta clinica Croatica (Tisak)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sit, Mustafa</au><au>Aktas, Gulali</au><au>Ozer, Bahri</au><au>Kocak, Mehmet Zahid</au><au>Erkus, Edip</au><au>Erkol, Hayri</au><au>Yaman, Semih</au><au>Savli, Haluk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES</atitle><jtitle>Acta clinica Croatica (Tisak)</jtitle><addtitle>Acta Clin Croat</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>58</volume><issue>3</issue><spage>417</spage><epage>420</epage><pages>417-420</pages><issn>0353-9466</issn><eissn>1333-9451</eissn><abstract>Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid nodules after precise pathologic diagnosis. We retrospectively analyzed hemograms of patients having undergone thyroid surgery for thyroid nodule between January 2013 and January 2015, and compared them to those recorded in healthy subjects. MPV was higher in the malignant thyroid nodule group than in the benign nodule group (9.1±1 fL
. 7.8±0.8 fL). The difference was statistically significant (p<0.001). Increased MPV should be considered as an assistive diagnostic tool in differentiating malignant and benign thyroid nodules. However, further prospective studies are required to confirm its usefulness in this population.</abstract><cop>Croatia</cop><pub>Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb</pub><pmid>31969752</pmid><doi>10.20471/acc.2019.58.03.03</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Correlation of Data Diagnosis, Differential Early Detection of Cancer - methods Female Humans Male Mean Platelet Volume - methods Middle Aged Original Scientific Papers Reproducibility of Results Retrospective Studies Thyroid Neoplasms - blood Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroid Nodule - blood Thyroid Nodule - diagnosis Thyroid Nodule - pathology Thyroid Nodule - surgery Thyroidectomy - methods Thyroidectomy - statistics & numerical data |
| title | MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES |
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