Association of Insulin-like Growth Factor 1 Concentrations with Risk for and Prognosis of Amyotrophic Lateral Sclerosis – Results from the ALS Registry Swabia
We investigated the associations of serum concentration of insulin-like growth factor 1 (IGF1) with risk and prognosis of ALS in the ALS registry (October 2010–June 2014, median follow-up 67.6 months) in a case-control and cohort study, respectively. Serum samples were measured for IGF-1. Informatio...
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| Veröffentlicht in: | Scientific reports 2020-01, Vol.10 (1), p.736-736, Article 736 |
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| creator | Nagel, Gabriele Peter, Raphael S. Rosenbohm, Angela Koenig, Wolfgang Dupuis, Luc Rothenbacher, Dietrich Ludolph, Albert C. |
| description | We investigated the associations of serum concentration of insulin-like growth factor 1 (IGF1) with risk and prognosis of ALS in the ALS registry (October 2010–June 2014, median follow-up 67.6 months) in a case-control and cohort study, respectively. Serum samples were measured for IGF-1. Information on covariates was collected by standardized questionnaire. We applied conditional logistic regression to appraise the risk and Cox proportional hazards models to appraise the prognostic value of IGF-1. Data of 294 ALS patients (mean age 65.4 (SD 11.0) years, 60.2% men) and 504 controls were included in the case-control study. Median serum IGF-1 concentrations were slightly higher in ALS cases than in controls (101 vs. 99.5 ng/ml). IGF-1 concentrations were not associated with ALS risk in the fully adjusted model (top vs. bottom quartile: OR 1.16; 95%-CI 0.73–1.84, p for trend = 0.44). Among 293 ALS cases (mean age 65.5 (SD 10.5) years, 56.8% men) 243 died during follow-up. We found a statistically significant inverse association between continuous IGF-1 concentrations and survival (p = 0.01). Very high values IGF-1 were associated with a better prognosis of ALS suggesting that functions related to IGF-1 could be involved in survival. |
| doi_str_mv | 10.1038/s41598-020-57744-x |
| format | Article |
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Serum samples were measured for IGF-1. Information on covariates was collected by standardized questionnaire. We applied conditional logistic regression to appraise the risk and Cox proportional hazards models to appraise the prognostic value of IGF-1. Data of 294 ALS patients (mean age 65.4 (SD 11.0) years, 60.2% men) and 504 controls were included in the case-control study. Median serum IGF-1 concentrations were slightly higher in ALS cases than in controls (101 vs. 99.5 ng/ml). IGF-1 concentrations were not associated with ALS risk in the fully adjusted model (top vs. bottom quartile: OR 1.16; 95%-CI 0.73–1.84, p for trend = 0.44). Among 293 ALS cases (mean age 65.5 (SD 10.5) years, 56.8% men) 243 died during follow-up. We found a statistically significant inverse association between continuous IGF-1 concentrations and survival (p = 0.01). Very high values IGF-1 were associated with a better prognosis of ALS suggesting that functions related to IGF-1 could be involved in survival.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-57744-x</identifier><identifier>PMID: 31959864</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/53/2422 ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - diagnosis ; Amyotrophic Lateral Sclerosis - mortality ; Biomarkers - blood ; Case-Control Studies ; Cohort Studies ; Female ; Follow-Up Studies ; Germany ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Insulin ; Insulin-Like Growth Factor I ; Insulin-like growth factors ; Life Sciences ; Logistic Models ; Male ; Medical prognosis ; Middle Aged ; multidisciplinary ; Neurobiology ; Neurons and Cognition ; Prognosis ; Proportional Hazards Models ; Registries ; Risk ; Santé publique et épidémiologie ; Science ; Science (multidisciplinary) ; Statistical analysis ; Survival ; Survival Rate</subject><ispartof>Scientific reports, 2020-01, Vol.10 (1), p.736-736, Article 736</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Serum samples were measured for IGF-1. Information on covariates was collected by standardized questionnaire. We applied conditional logistic regression to appraise the risk and Cox proportional hazards models to appraise the prognostic value of IGF-1. Data of 294 ALS patients (mean age 65.4 (SD 11.0) years, 60.2% men) and 504 controls were included in the case-control study. Median serum IGF-1 concentrations were slightly higher in ALS cases than in controls (101 vs. 99.5 ng/ml). IGF-1 concentrations were not associated with ALS risk in the fully adjusted model (top vs. bottom quartile: OR 1.16; 95%-CI 0.73–1.84, p for trend = 0.44). Among 293 ALS cases (mean age 65.5 (SD 10.5) years, 56.8% men) 243 died during follow-up. We found a statistically significant inverse association between continuous IGF-1 concentrations and survival (p = 0.01). 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Serum samples were measured for IGF-1. Information on covariates was collected by standardized questionnaire. We applied conditional logistic regression to appraise the risk and Cox proportional hazards models to appraise the prognostic value of IGF-1. Data of 294 ALS patients (mean age 65.4 (SD 11.0) years, 60.2% men) and 504 controls were included in the case-control study. Median serum IGF-1 concentrations were slightly higher in ALS cases than in controls (101 vs. 99.5 ng/ml). IGF-1 concentrations were not associated with ALS risk in the fully adjusted model (top vs. bottom quartile: OR 1.16; 95%-CI 0.73–1.84, p for trend = 0.44). Among 293 ALS cases (mean age 65.5 (SD 10.5) years, 56.8% men) 243 died during follow-up. We found a statistically significant inverse association between continuous IGF-1 concentrations and survival (p = 0.01). Very high values IGF-1 were associated with a better prognosis of ALS suggesting that functions related to IGF-1 could be involved in survival.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31959864</pmid><doi>10.1038/s41598-020-57744-x</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4310-9500</orcidid><orcidid>https://orcid.org/0000-0001-6185-8535</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/53/2422 Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - mortality Biomarkers - blood Case-Control Studies Cohort Studies Female Follow-Up Studies Germany Health risk assessment Humanities and Social Sciences Humans Insulin Insulin-Like Growth Factor I Insulin-like growth factors Life Sciences Logistic Models Male Medical prognosis Middle Aged multidisciplinary Neurobiology Neurons and Cognition Prognosis Proportional Hazards Models Registries Risk Santé publique et épidémiologie Science Science (multidisciplinary) Statistical analysis Survival Survival Rate |
| title | Association of Insulin-like Growth Factor 1 Concentrations with Risk for and Prognosis of Amyotrophic Lateral Sclerosis – Results from the ALS Registry Swabia |
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