Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

Infection with transmissible gastroenteritis virus (TGEV) has been associated with villous atrophy within 48 h, which seriously disrupts intestinal homeostasis. However, the underlying mechanisms remain elusive. In this study, we found that TGEV infection severely disrupted intestinal homeostasis vi...

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Veröffentlicht in:	Cell death & disease 2020-01, Vol.11 (1), p.40-40, Article 40
Hauptverfasser:	Wu, Aimin, Yu, Bing, Zhang, Keying, Xu, Zhiwen, Wu, De, He, Jun, Luo, Junqiu, Luo, Yuheng, Yu, Jie, Zheng, Ping, Che, Lianqiang, Mao, Xiangbing, Huang, Zhiqing, Wang, Lan, Zhao, Jun, Chen, Daiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/19 14/32 42/35 631/136/142 631/136/1425 631/532/1360 631/532/2139 631/532/2441 96/100 96/31 96/47 Aminopeptidase Animals Antibodies Atrophy Biochemistry Biomedical and Life Sciences CD13 Antigens - metabolism CD24 Antigen - metabolism Cell Biology Cell Culture Cell Differentiation Cell Line Cell Lineage Cell Proliferation Cell Self Renewal Diarrhea Enterocytes Gastroenteritis Gastroenteritis, Transmissible, of Swine - pathology Gastroenteritis, Transmissible, of Swine - virology Goblet cells Homeostasis Immunology Infections Intestine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Jejunum Life Sciences Male Membrane Proteins - genetics Membrane Proteins - metabolism Mitochondria Models, Biological Mucin Paneth cells Paneth Cells - metabolism Paneth Cells - pathology Paneth Cells - virology Promoter Regions, Genetic Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Notch - metabolism Signal Transduction Stem cells Stem Cells - metabolism Stem Cells - pathology Swine Transmissible gastroenteritis Transmissible gastroenteritis virus - physiology Viral Proteins - metabolism
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