Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation

Background & Aims. Oxidative stress-related liver diseases were shown to be associated with elevated serum thyroid stimulating hormone (TSH) levels. Mitochondria are the main source of cellular reactive oxygen species. However, the relationship between TSH and hepatic mitochondrial stress/dysfun...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-12
Hauptverfasser:	Gao, Ling, Li, Qiu, Zhou, Xinli, Mao, Jinbao, Wang, Xiaolei, Zhao, Jiajun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetylation Analysis Animals Genes Glycoproteins Hormones Hypothyroidism Insulin resistance Liver Liver - enzymology Liver cancer Liver diseases Metastasis Mice Mice, Knockout Mitochondria Mitochondria, Liver - enzymology Mitochondria, Liver - genetics Oxidative Stress Peptidyl-Prolyl Isomerase F - genetics Peptidyl-Prolyl Isomerase F - metabolism Pituitary hormones Reactive oxygen species Receptors, Thyrotropin - genetics Receptors, Thyrotropin - metabolism Studies Thyroid gland Thyroid hormones Thyrotropin - genetics Thyrotropin - metabolism Transgenic animals Weaning
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