Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis
Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy. Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. Erigeron annuus (EA) has antioxidant properties...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-10 |
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| creator | Ji, Yun-Jeong Kim, Hyung Don Kim, Dong Hwi Park, Jeong-Yong Lee, Ji Yeon Seo, Kyung Hye |
| description | Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy. Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. Erigeron annuus (EA) has antioxidant properties and could protect neurons from oxidative stress. In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells. We quantified 18 types of phenolic compounds using high-performance liquid chromatography. Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase. In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA. These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes. |
| doi_str_mv | 10.1155/2020/3945194 |
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Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. Erigeron annuus (EA) has antioxidant properties and could protect neurons from oxidative stress. In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells. We quantified 18 types of phenolic compounds using high-performance liquid chromatography. Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase. In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA. These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/3945194</identifier><identifier>PMID: 31998396</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Aluminum ; Antioxidants ; Apoptosis ; Autophagy ; BAX protein ; Bcl-x protein ; Caspase-3 ; Caspase-8 ; Catalase ; Cell cycle ; Enzymes ; Erigeron annuus ; Flowers ; Glutathione peroxidase ; High performance liquid chromatography ; Immunoglobulins ; Liquid chromatography ; Nervous system diseases ; Neurodegenerative diseases ; Neurons ; Oxidative stress ; Phagocytosis ; Phenolic compounds ; Phenols ; Potassium ; Proteins ; Reactive oxygen species ; Superoxide ; Superoxide dismutase</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Ji Yeon Lee et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Ji Yeon Lee et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Ji Yeon Lee et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9a9a13eb98777c26181484325feb4e163c27fbf454adb0ed43259ffc1853a6b73</citedby><cites>FETCH-LOGICAL-c499t-9a9a13eb98777c26181484325feb4e163c27fbf454adb0ed43259ffc1853a6b73</cites><orcidid>0000-0002-8155-8051</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970001/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970001/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31998396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Da Silva Filho, Ademar A.</contributor><creatorcontrib>Ji, Yun-Jeong</creatorcontrib><creatorcontrib>Kim, Hyung Don</creatorcontrib><creatorcontrib>Kim, Dong Hwi</creatorcontrib><creatorcontrib>Park, Jeong-Yong</creatorcontrib><creatorcontrib>Lee, Ji Yeon</creatorcontrib><creatorcontrib>Seo, Kyung Hye</creatorcontrib><title>Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy. Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. Erigeron annuus (EA) has antioxidant properties and could protect neurons from oxidative stress. In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells. We quantified 18 types of phenolic compounds using high-performance liquid chromatography. Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase. In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA. These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes.</description><subject>Acids</subject><subject>Aluminum</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>BAX protein</subject><subject>Bcl-x protein</subject><subject>Caspase-3</subject><subject>Caspase-8</subject><subject>Catalase</subject><subject>Cell cycle</subject><subject>Enzymes</subject><subject>Erigeron annuus</subject><subject>Flowers</subject><subject>Glutathione peroxidase</subject><subject>High performance liquid chromatography</subject><subject>Immunoglobulins</subject><subject>Liquid chromatography</subject><subject>Nervous system diseases</subject><subject>Neurodegenerative diseases</subject><subject>Neurons</subject><subject>Oxidative stress</subject><subject>Phagocytosis</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Potassium</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Superoxide</subject><subject>Superoxide 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Based Complement Alternat Med</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy. Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. Erigeron annuus (EA) has antioxidant properties and could protect neurons from oxidative stress. In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells. We quantified 18 types of phenolic compounds using high-performance liquid chromatography. Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase. In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA. These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31998396</pmid><doi>10.1155/2020/3945194</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8155-8051</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Aluminum Antioxidants Apoptosis Autophagy BAX protein Bcl-x protein Caspase-3 Caspase-8 Catalase Cell cycle Enzymes Erigeron annuus Flowers Glutathione peroxidase High performance liquid chromatography Immunoglobulins Liquid chromatography Nervous system diseases Neurodegenerative diseases Neurons Oxidative stress Phagocytosis Phenolic compounds Phenols Potassium Proteins Reactive oxygen species Superoxide Superoxide dismutase |
| title | Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis |
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