Anaphylaxis induced by Thalassophryne nattereri venom in mice is an IgE/IgG1-mediated, IL-4-dependent phenomenon

We hypothesized that beyond the Thalassophryne nattereri venoms ability to induce in mice a strong specific-Th2 response with high levels of specific IgE/IgG1, it would be able to trigger anaphylaxis in sensitized individuals. To investigate whether the venom is capable of inducing an allergic react...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.584, Article 584
Hauptverfasser:	Bruni, Fernanda Miriane, Coutinho, Erica Maria Martins, Andrade-Barros, Aline Ingrid, Grund, Lidiane Zito, Lopes-Ferreira, Monica, Lima, Carla
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 14/63 631/250/249/2510/9 64/60 692/699 82/29 Administration, Cutaneous Administration, Oral Anaphylaxis Anaphylaxis - chemically induced Anaphylaxis - immunology Animals Batrachoidiformes - metabolism Disease Models, Animal Eotaxin Female Fish Venoms - adverse effects Fish Venoms - immunology Gene Knockout Techniques Helper cells Humanities and Social Sciences Humans Hypersensitivity Immunoglobulin E Immunoglobulin E - immunology Immunoglobulin G Immunoglobulin G - immunology Inflammation Injections, Intraperitoneal Interferon-gamma - metabolism Interleukin 4 Interleukin 5 Interleukin-4 - genetics Interleukin-4 - metabolism Leukocytes (eosinophilic) Lymphocytes T Mast cells Mice Mice, Inbred BALB C Mice, Inbred C57BL multidisciplinary Rats Science Science (multidisciplinary) Thalassophryne nattereri Venom γ-Interferon
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