The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

Recent evidences indicate that mitochondrial genes and function are decreased in active ulcerative colitis (UC) patients, in particular, the activity of Complex I of the electron transport chain is heavily compromised. MCJ is a mitochondrial inner membrane protein identified as a natural inhibitor o...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.572, Article 572
Hauptverfasser:	Pascual-Itoiz, Miguel Angel, Peña-Cearra, Ainize, Martín-Ruiz, Itziar, Lavín, José Luis, Simó, Carolina, Rodríguez, Héctor, Atondo, Estibaliz, Flores, Juana María, Carreras-González, Ana, Tomás-Cortázar, Julen, Barriales, Diego, Palacios, Ainhoa, García-Cañas, Virginia, Pellón, Aize, Fullaondo, Asier, Aransay, Ana Mª, Prados-Rosales, Rafael, Martín, Rebeca, Anguita, Juan, Abecia, Leticia
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/31 13/51 14/1 14/28 14/34 14/5 14/63 38 38/22 38/23 38/39 38/90 631/250/256/2516 692/4020/1503/257/1389 ADAM17 Protein - genetics Animals Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Cell membranes Colitis, Ulcerative - genetics Colitis, Ulcerative - microbiology Colon Disease Models, Animal Dysbiosis - genetics Electron transport chain Gene Deletion Gene expression Gene Expression Regulation HSP40 Heat-Shock Proteins - genetics Humanities and Social Sciences Humans Immunoglobulin A Inflammation Inflammatory bowel disease Life Sciences Membrane proteins Mice Microbiota Mitochondria Mitochondrial Proteins - genetics Molecular Chaperones - genetics multidisciplinary MyD88 protein Phylogeny Receptors, Tumor Necrosis Factor, Type I - genetics Science Science (multidisciplinary) Severity of Illness Index Tissue inhibitor of metalloproteinase 3 Tissue Inhibitor of Metalloproteinase-3 - genetics TLR9 protein Toll-like receptors Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - genetics Ulcerative colitis
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