Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds. The development of albumin-bound drugs is gaining increased importance in the targeted delivery of cancer therapy. Intra...

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Veröffentlicht in:	Drug delivery 2020-01, Vol.27 (1), p.40-53
Hauptverfasser:	Van de Sande, Leen, Cosyns, Sarah, Willaert, Wouter, Ceelen, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Aerosols Albumin Albumins - administration & dosage Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Binding sites Biological Transport Cancer therapies Cell adhesion & migration Chemotherapy Collagen Dose-Response Relationship, Drug Drug Carriers - administration & dosage Drug dosages Humans Injections, Intraperitoneal intraperitoneal delivery Ligands Medical prognosis Metastasis Nanoparticles - chemistry Pancreatic cancer peritoneal metastasis Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - pathology peritoneum Peritoneum - anatomy & histology Peritoneum - pathology Protein Binding - physiology Surgery
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