Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223

Cancer patients are increasingly treated with alpha-particle-emitting radiopharmaceuticals. At the subcellular level, alpha particles induce densely spaced ionizations and molecular damage. Induction of DNA lesions, especially clustered DNA double-strand breaks (DSBs), threatens a cell's surviv...

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Veröffentlicht in:	Cancers 2019-11, Vol.11 (12), p.1877
Hauptverfasser:	Scherthan, Harry, Lee, Jin-Ho, Maus, Emanuel, Schumann, Sarah, Muhtadi, Razan, Chojowski, Robert, Port, Matthias, Lassmann, Michael, Bestvater, Felix, Hausmann, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia telangiectasia mutated protein Chromatin Data analysis Deoxyribonucleic acid DNA DNA damage DNA repair DNA structure Double-strand break repair Kinases Leukocytes Light microscopy Localization Metastasis Microscopy MRE11 protein Prostate cancer Proteins Radiation α Radiation
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