The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma
Osteosarcoma is one of the first two cause of cancer-related death in children and young adolescents. Inhibitor of Growth 4 (ING4) is a member of the ING tumor suppressor family and play an important role in many cellular processes. The purpose of this study was to explore the correlation between ex...
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| Veröffentlicht in: | International journal of clinical and experimental pathology 2017-01, Vol.10 (9), p.10003-10008 |
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| creator | Li, Fengguo Sun, Jianhua Liu, Bin Zhang, Xinhu Zhou, Lianjun Pang, Jutao |
| description | Osteosarcoma is one of the first two cause of cancer-related death in children and young adolescents. Inhibitor of Growth 4 (ING4) is a member of the ING tumor suppressor family and play an important role in many cellular processes. The purpose of this study was to explore the correlation between
expression and the prognosis of osteosarcoma patients.
mRNA and protein expressions in osteosarcoma and normal tissues were detected by quantitative real-time transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) method, respectively. Chi-square test was adopted to estimated the relationship of
expression and clinical parameters of osteosarcoma patients. Besides, the overall survival of osteosarcoma patients was evaluated by Kaplan-Meier method. The potential of
as a prognostic marker gene was addressed by Cox regression analysis.
Down-regulated expression of
mRNA and protein were observed in osteosarcoma tissues.
expression was significantly associated with metastasis (
= 0.030) and recurrence (
= 0.008), but not other clinical features (
> 0.05). Cox regression analysis indicated that
can be used as an independent prognotic biomarker for osteosarcoma, in univariate and multivariate analysis (
= 0.004, HR = 3.945, 95 % CI = 1.565-9.940;
= 0.001, HR = 4.213, 95 % CI = 1.747-10.161).
Taken together,
was down-regulated in osteosarcoma tissues.
can act as an independent prognostic factor for osteosarcoma. |
| format | Article |
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expression and the prognosis of osteosarcoma patients.
mRNA and protein expressions in osteosarcoma and normal tissues were detected by quantitative real-time transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) method, respectively. Chi-square test was adopted to estimated the relationship of
expression and clinical parameters of osteosarcoma patients. Besides, the overall survival of osteosarcoma patients was evaluated by Kaplan-Meier method. The potential of
as a prognostic marker gene was addressed by Cox regression analysis.
Down-regulated expression of
mRNA and protein were observed in osteosarcoma tissues.
expression was significantly associated with metastasis (
= 0.030) and recurrence (
= 0.008), but not other clinical features (
> 0.05). Cox regression analysis indicated that
can be used as an independent prognotic biomarker for osteosarcoma, in univariate and multivariate analysis (
= 0.004, HR = 3.945, 95 % CI = 1.565-9.940;
= 0.001, HR = 4.213, 95 % CI = 1.747-10.161).
Taken together,
was down-regulated in osteosarcoma tissues.
can act as an independent prognostic factor for osteosarcoma.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 31966890</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>International journal of clinical and experimental pathology, 2017-01, Vol.10 (9), p.10003-10008</ispartof><rights>IJCEP Copyright © 2017.</rights><rights>IJCEP Copyright © 2017 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965907/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965907/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31966890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Fengguo</creatorcontrib><creatorcontrib>Sun, Jianhua</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Zhang, Xinhu</creatorcontrib><creatorcontrib>Zhou, Lianjun</creatorcontrib><creatorcontrib>Pang, Jutao</creatorcontrib><title>The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>Osteosarcoma is one of the first two cause of cancer-related death in children and young adolescents. Inhibitor of Growth 4 (ING4) is a member of the ING tumor suppressor family and play an important role in many cellular processes. The purpose of this study was to explore the correlation between
expression and the prognosis of osteosarcoma patients.
mRNA and protein expressions in osteosarcoma and normal tissues were detected by quantitative real-time transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) method, respectively. Chi-square test was adopted to estimated the relationship of
expression and clinical parameters of osteosarcoma patients. Besides, the overall survival of osteosarcoma patients was evaluated by Kaplan-Meier method. The potential of
as a prognostic marker gene was addressed by Cox regression analysis.
Down-regulated expression of
mRNA and protein were observed in osteosarcoma tissues.
expression was significantly associated with metastasis (
= 0.030) and recurrence (
= 0.008), but not other clinical features (
> 0.05). Cox regression analysis indicated that
can be used as an independent prognotic biomarker for osteosarcoma, in univariate and multivariate analysis (
= 0.004, HR = 3.945, 95 % CI = 1.565-9.940;
= 0.001, HR = 4.213, 95 % CI = 1.747-10.161).
Taken together,
was down-regulated in osteosarcoma tissues.
can act as an independent prognostic factor for osteosarcoma.</description><subject>Original</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkF9LwzAUxYMgbk6_guTRl0L-NU1eBBk6BwNfJvgW7tp0jbRNTdINv70Vp-jT4dx7-B04Z2hONZcZkyyfocsY3wiRlAlygWacaimVJnP0um0shhh96SA532NfY9c3bueSD19mFfwxNVjgo5vEpYiH4Pe9j8mV-ADtaKc8nqz1e9tPtwih9B1cofMa2mivT7pAL48P2-VTtnlerZf3m2xgUqaM1ZKWlnCuFKeqqmgtWLHjeUnqHKhWpOBcEFkJVWtRWIAKoNCqVpSpogDLF-jumzuMu85Wpe1TgNYMwXUQPowHZ_5_eteYvT8YqWWuJ_wC3Z4Awb-PNibTuVjatoXe-jEaxgUXWpM8n6I3f7t-S37m5J9glXHD</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Li, Fengguo</creator><creator>Sun, Jianhua</creator><creator>Liu, Bin</creator><creator>Zhang, Xinhu</creator><creator>Zhou, Lianjun</creator><creator>Pang, Jutao</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma</title><author>Li, Fengguo ; Sun, Jianhua ; Liu, Bin ; Zhang, Xinhu ; Zhou, Lianjun ; Pang, Jutao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-2f61ce03388318dd1f427b35c0f5a1980733406d48f947eaadaa798f812877ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Fengguo</creatorcontrib><creatorcontrib>Sun, Jianhua</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Zhang, Xinhu</creatorcontrib><creatorcontrib>Zhou, Lianjun</creatorcontrib><creatorcontrib>Pang, Jutao</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of clinical and experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Fengguo</au><au>Sun, Jianhua</au><au>Liu, Bin</au><au>Zhang, Xinhu</au><au>Zhou, Lianjun</au><au>Pang, Jutao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma</atitle><jtitle>International journal of clinical and experimental pathology</jtitle><addtitle>Int J Clin Exp Pathol</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>10</volume><issue>9</issue><spage>10003</spage><epage>10008</epage><pages>10003-10008</pages><eissn>1936-2625</eissn><abstract>Osteosarcoma is one of the first two cause of cancer-related death in children and young adolescents. Inhibitor of Growth 4 (ING4) is a member of the ING tumor suppressor family and play an important role in many cellular processes. The purpose of this study was to explore the correlation between
expression and the prognosis of osteosarcoma patients.
mRNA and protein expressions in osteosarcoma and normal tissues were detected by quantitative real-time transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) method, respectively. Chi-square test was adopted to estimated the relationship of
expression and clinical parameters of osteosarcoma patients. Besides, the overall survival of osteosarcoma patients was evaluated by Kaplan-Meier method. The potential of
as a prognostic marker gene was addressed by Cox regression analysis.
Down-regulated expression of
mRNA and protein were observed in osteosarcoma tissues.
expression was significantly associated with metastasis (
= 0.030) and recurrence (
= 0.008), but not other clinical features (
> 0.05). Cox regression analysis indicated that
can be used as an independent prognotic biomarker for osteosarcoma, in univariate and multivariate analysis (
= 0.004, HR = 3.945, 95 % CI = 1.565-9.940;
= 0.001, HR = 4.213, 95 % CI = 1.747-10.161).
Taken together,
was down-regulated in osteosarcoma tissues.
can act as an independent prognostic factor for osteosarcoma.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>31966890</pmid><tpages>6</tpages></addata></record> |
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| subjects | Original |
| title | The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma |
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