Induction of E6AP by microRNA-302c dysregulation inhibits TGF-β-dependent fibrogenesis in hepatic stellate cells

Hepatic stellate cells (HSCs) are essential for liver fibrosis. E6 associated protein (E6AP) is one of the E3-ubiquitin-protein ligase and has been studied in proliferation and cellular stress. Currently, no information is available on the role of E6AP on transforming growth factor-β (TGF-β) signali...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.444-444, Article 444
Hauptverfasser:	Kim, Ji Young, Kim, Kyu Min, Yang, Ji Hye, Cho, Sam Seok, Kim, Seung Jung, Park, Su Jung, Ahn, Sang‐Gun, Lee, Gum Hwa, Yang, Jin Won, Lim, Sung Chul, Kang, Keon Wook, Ki, Sung Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 692/4020/4021/1607/1605 692/4020/4021/288/2140 96/95 Carbon tetrachloride Cell Line Cellular stress response Fibrosis Hepatic Stellate Cells - pathology Hepatocytes Humanities and Social Sciences Humans Kinases Liver Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology MAP kinase MicroRNAs MicroRNAs - genetics miRNA mRNA stability multidisciplinary Phosphorylation Plasminogen activator inhibitors Protein kinase Proteins Science Science (multidisciplinary) Signal Transduction Smad protein Stellate cells Transforming Growth Factor beta - metabolism Transforming growth factor-b Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Up-Regulation
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