High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in t...
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| Veröffentlicht in: | Scientific reports 2020-01, Vol.10 (1), p.428-428, Article 428 |
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| description | The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p |
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Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-57366-y</identifier><identifier>PMID: 31949271</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2422 ; 692/617/375/1917/1285 ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - immunology ; Cell Count ; Female ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Kaplan-Meier Estimate ; Lymphocytes ; Lymphocytes - cytology ; Male ; Middle Aged ; multidisciplinary ; Neutrophils ; Neutrophils - cytology ; Regression analysis ; Science ; Science (multidisciplinary) ; Survival</subject><ispartof>Scientific reports, 2020-01, Vol.10 (1), p.428-428, Article 428</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-52a2846686123c89778bcb2ed83ef3153896d3f1f15477663395ad168d4590d83</citedby><cites>FETCH-LOGICAL-c522t-52a2846686123c89778bcb2ed83ef3153896d3f1f15477663395ad168d4590d83</cites><orcidid>0000-0002-3325-6358 ; 0000-0002-6816-8067</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31949271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Seok-Jin</creatorcontrib><creatorcontrib>Hong, Yoon-Ho</creatorcontrib><creatorcontrib>Kim, Sung-Min</creatorcontrib><creatorcontrib>Shin, Je-Young</creatorcontrib><creatorcontrib>Suh, Young Ju</creatorcontrib><creatorcontrib>Sung, Jung-Joon</creatorcontrib><title>High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.</description><subject>692/53/2422</subject><subject>692/617/375/1917/1285</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - immunology</subject><subject>Cell Count</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neutrophils</subject><subject>Neutrophils - cytology</subject><subject>Regression analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Survival</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9rFTEUxYMottR-gS4k4MZNNP8n2QhS1AqFbtp1yMtk3qTMTMYk82C-ffM6tVYXZpPA-d1z780B4ILgTwQz9TlzIrRCmGgkGiYlWl-BU4q5QJRR-vrF-wSc53yP6xFUc6LfghNGNNe0IafAX4V9Dye_lBTnPgyoRDSs49xHtxYPky0hwjn5NriSYe5jKjAv6RAOdoDt8qhPMEzQjmvcPBwcbPGp6tkNPsUc8jvwprND9udP9xm4-_7t9vIKXd_8-Hn59Ro5QWlBglqquJRKEsqc0k2jdm5HfauY7xgRTGnZso50RPCmkZIxLWxLpGq50LhSZ-DL5jsvu9G3zk-lzmHmFEabVhNtMH8rU-jNPh6M1FJgjavBxyeDFH8tPhczhuz8MNjJxyUbyjiRRGt97PXhH_Q-Lmmq6x0pyhrN8dGQbpSrH5GT756HIdgcgzRbkKYGaR6DNGstev9yjeeS37FVgG1ArtK09-lP7__YPgB8GqtQ</recordid><startdate>20200116</startdate><enddate>20200116</enddate><creator>Choi, Seok-Jin</creator><creator>Hong, Yoon-Ho</creator><creator>Kim, Sung-Min</creator><creator>Shin, Je-Young</creator><creator>Suh, Young Ju</creator><creator>Sung, Jung-Joon</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3325-6358</orcidid><orcidid>https://orcid.org/0000-0002-6816-8067</orcidid></search><sort><creationdate>20200116</creationdate><title>High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis</title><author>Choi, Seok-Jin ; 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Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31949271</pmid><doi>10.1038/s41598-019-57366-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3325-6358</orcidid><orcidid>https://orcid.org/0000-0002-6816-8067</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2422 692/617/375/1917/1285 Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - immunology Cell Count Female Health risk assessment Humanities and Social Sciences Humans Kaplan-Meier Estimate Lymphocytes Lymphocytes - cytology Male Middle Aged multidisciplinary Neutrophils Neutrophils - cytology Regression analysis Science Science (multidisciplinary) Survival |
| title | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
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