Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention

Background 3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of the mammalian siderophore and regulate intracellular iron metabolism. Here we aim to explore the expression and possible function of BDH2 in nasopharyngeal carcinoma (NPC). Methods...

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Veröffentlicht in:	British journal of cancer 2020-01, Vol.122 (1), p.102-110
Hauptverfasser:	Li, Bo, Liao, Zhipeng, Mo, Yingxi, Zhao, Weilin, Zhou, Xiaohui, Xiao, Xiling, Cui, Wanmeng, Feng, Guofei, Zhong, Suhua, Liang, Yushan, Du, Chunping, Huang, Guangwu, Li, Ping, Xiao, Xue, Zhou, Xiaoying, Wang, Rensheng, Zhang, Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyrate dehydrogenase 631/67/1244 631/67/1536 Animals Assaying Biomedical and Life Sciences Biomedicine Cancer Research Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Colorimetry Dehydrogenase Dehydrogenases DNA microarrays Down-Regulation Drug Resistance Ectopic expression Epidemiology Epithelial-Mesenchymal Transition - genetics Gene expression Gene Expression Regulation, Neoplastic Heterografts Humans Hydroxybutyrate Dehydrogenase - genetics Hydroxybutyrate Dehydrogenase - metabolism Immunohistochemistry Inactivation Intracellular Iron Iron - metabolism Kinases Male Mesenchyme Metabolism Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Molecular Medicine Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Oncology Polymerase chain reaction Throat cancer Transcription Transfection Tumor Burden - genetics Tumors Wound healing
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