Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs
sp. treatment has become a challenge due to the formation of biofilms which favor resistance to conventional antifungals, making the search for new compounds necessary. The objective of this study was to identify the composition of the Benth. leaf ethanolic extract and to verify its antifungal activ...
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| Veröffentlicht in: | Antibiotics (Basel) 2019-12, Vol.8 (4), p.250 |
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| creator | de Freitas, Maria Audilene Silva Alves, Adryelle Idalina Andrade, Jacqueline Cosmo Leite-Andrade, Melyna Chaves Lucas Dos Santos, Antonia Thassya Felix de Oliveira, Tatiana Dos Santos, Franz de Assis G Silva Buonafina, Maria Daniela Melo Coutinho, Henrique Douglas Alencar de Menezes, Irwin Rose Bezerra Morais-Braga, Maria Flaviana Pereira Neves, Rejane |
| description | sp. treatment has become a challenge due to the formation of biofilms which favor resistance to conventional antifungals, making the search for new compounds necessary. The objective of this study was to identify the composition of the
Benth. leaf ethanolic extract and to verify its antifungal activity against
sp. and its biofilms. The composition identification was performed using the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technique. The antifungal activity of extract and fluconazole against planktonic cells and biofilms was verified through the minimum inhibitory concentration (MIC) following biofilm induction and quantification in acrylic resin discs by reducing tetrazolic salt, with all isolates forming biofilms within 48 h. Six constituents were identified in the extract, and the compounds identified are derivatives from phenolic compounds such as flavonoids (epi) gallocatechin Dimer, epigallocatechin and gallocatechin, Myricetin-O-hexoside, Myricitrin, and Quercetin-O-rhamnoside. The extract reduced biofilm formation in some of the strains analyzed, namely
URM5732,
INCQS40042, and
URM6352. This reduction was also observed in the treatment with fluconazole with some of the analyzed strains. The extract showed significant antifungal and anti-biofilm activities with some of the strains tested. |
| doi_str_mv | 10.3390/antibiotics8040250 |
| format | Article |
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Benth. leaf ethanolic extract and to verify its antifungal activity against
sp. and its biofilms. The composition identification was performed using the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technique. The antifungal activity of extract and fluconazole against planktonic cells and biofilms was verified through the minimum inhibitory concentration (MIC) following biofilm induction and quantification in acrylic resin discs by reducing tetrazolic salt, with all isolates forming biofilms within 48 h. Six constituents were identified in the extract, and the compounds identified are derivatives from phenolic compounds such as flavonoids (epi) gallocatechin Dimer, epigallocatechin and gallocatechin, Myricetin-O-hexoside, Myricitrin, and Quercetin-O-rhamnoside. The extract reduced biofilm formation in some of the strains analyzed, namely
URM5732,
INCQS40042, and
URM6352. This reduction was also observed in the treatment with fluconazole with some of the analyzed strains. The extract showed significant antifungal and anti-biofilm activities with some of the strains tested.</description><identifier>ISSN: 2079-6382</identifier><identifier>EISSN: 2079-6382</identifier><identifier>DOI: 10.3390/antibiotics8040250</identifier><identifier>PMID: 31817228</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acrylic resins ; Antifungal activity ; Antifungal agents ; Antimicrobial agents ; Biofilms ; Candida ; Candida krusei ; Chromatography ; Composition ; Control ; Dimers ; Enzymes ; Evaluation ; Extracellular matrix ; Flavonoids ; Fluconazole ; Fungicides ; Health aspects ; Herbal medicine ; High performance liquid chromatography ; Infections ; Isoflavones ; Leaves ; Liquid chromatography ; Magnoliopsida ; Mass spectrometry ; Mass spectroscopy ; Medicinal plants ; Microbial mats ; Microorganisms ; Minimum inhibitory concentration ; Pathogens ; Phenolic compounds ; Phenols ; Planktonic cells ; Quadrupoles ; Quercetin ; Scientific imaging ; Spectroscopy ; Time</subject><ispartof>Antibiotics (Basel), 2019-12, Vol.8 (4), p.250</ispartof><rights>COPYRIGHT 2019 MDPI AG</rights><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-780c13ab1016380037363570e2bf591270274458d865176e0b10fdc4a0e7d4953</citedby><cites>FETCH-LOGICAL-c458t-780c13ab1016380037363570e2bf591270274458d865176e0b10fdc4a0e7d4953</cites><orcidid>0000-0001-5722-090X ; 0000-0002-6634-4207 ; 0000-0003-1065-9581</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963540/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963540/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31817228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Freitas, Maria Audilene</creatorcontrib><creatorcontrib>Silva Alves, Adryelle Idalina</creatorcontrib><creatorcontrib>Andrade, Jacqueline Cosmo</creatorcontrib><creatorcontrib>Leite-Andrade, Melyna Chaves</creatorcontrib><creatorcontrib>Lucas Dos Santos, Antonia Thassya</creatorcontrib><creatorcontrib>Felix de Oliveira, Tatiana</creatorcontrib><creatorcontrib>Dos Santos, Franz de Assis G</creatorcontrib><creatorcontrib>Silva Buonafina, Maria Daniela</creatorcontrib><creatorcontrib>Melo Coutinho, Henrique Douglas</creatorcontrib><creatorcontrib>Alencar de Menezes, Irwin Rose</creatorcontrib><creatorcontrib>Bezerra Morais-Braga, Maria Flaviana</creatorcontrib><creatorcontrib>Pereira Neves, Rejane</creatorcontrib><title>Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs</title><title>Antibiotics (Basel)</title><addtitle>Antibiotics (Basel)</addtitle><description>sp. treatment has become a challenge due to the formation of biofilms which favor resistance to conventional antifungals, making the search for new compounds necessary. The objective of this study was to identify the composition of the
Benth. leaf ethanolic extract and to verify its antifungal activity against
sp. and its biofilms. The composition identification was performed using the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technique. The antifungal activity of extract and fluconazole against planktonic cells and biofilms was verified through the minimum inhibitory concentration (MIC) following biofilm induction and quantification in acrylic resin discs by reducing tetrazolic salt, with all isolates forming biofilms within 48 h. Six constituents were identified in the extract, and the compounds identified are derivatives from phenolic compounds such as flavonoids (epi) gallocatechin Dimer, epigallocatechin and gallocatechin, Myricetin-O-hexoside, Myricitrin, and Quercetin-O-rhamnoside. The extract reduced biofilm formation in some of the strains analyzed, namely
URM5732,
INCQS40042, and
URM6352. This reduction was also observed in the treatment with fluconazole with some of the analyzed strains. The extract showed significant antifungal and anti-biofilm activities with some of the strains tested.</description><subject>Acrylic resins</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antimicrobial agents</subject><subject>Biofilms</subject><subject>Candida</subject><subject>Candida krusei</subject><subject>Chromatography</subject><subject>Composition</subject><subject>Control</subject><subject>Dimers</subject><subject>Enzymes</subject><subject>Evaluation</subject><subject>Extracellular matrix</subject><subject>Flavonoids</subject><subject>Fluconazole</subject><subject>Fungicides</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>High performance liquid chromatography</subject><subject>Infections</subject><subject>Isoflavones</subject><subject>Leaves</subject><subject>Liquid chromatography</subject><subject>Magnoliopsida</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicinal plants</subject><subject>Microbial mats</subject><subject>Microorganisms</subject><subject>Minimum inhibitory concentration</subject><subject>Pathogens</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Planktonic cells</subject><subject>Quadrupoles</subject><subject>Quercetin</subject><subject>Scientific imaging</subject><subject>Spectroscopy</subject><subject>Time</subject><issn>2079-6382</issn><issn>2079-6382</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNplUk1v1DAQjRCIVqV_oAdkiQuXLf5IYueCtCxbqLRSpULP1sRxdqfy2kvsrLo_hX-Lo35QqC_2aN68N88zRXHG6LkQDf0EPmGLIaGJipaUV_RVccypbGa1UPz1s_dRcRrjLc2nYUJR9bY4Ekwxybk6Ln4v9-BGSBg8CT1JG0vmmbkf_RocmZuEe0yHx9QKDXgEco1r7ICsLPRkmTbgg0NDlndpAJMIrAF9TOQLhh7dNpKLMGxtR9oDWYDvpsofu3NyGYODZCNBn4WGw0RxbWOOvmI08V3xpgcX7enDfVLcXCx_Lr7PVlffLhfz1cyUlUozqahhAlpGWTZLqZCiFpWklrd91TAuKZdlRnaqrpisLc3IvjMlUCu7sqnESfH5nnc3trlLY3124fRuwC0MBx0A9b8Zjxu9DntdN1mopJng4wPBEH6NNia9zf1b58DbMEbNBRelZEJMWh_-g96GcfDZnuZVWTVcykr-ReURWI2-D9O_TqR6XrO6yeNmKqP4PcoMIcbB9k8tM6qnFdEvVyQXvX9u9qnkcSHEH1hauSA</recordid><startdate>20191204</startdate><enddate>20191204</enddate><creator>de Freitas, Maria Audilene</creator><creator>Silva Alves, Adryelle Idalina</creator><creator>Andrade, Jacqueline Cosmo</creator><creator>Leite-Andrade, Melyna Chaves</creator><creator>Lucas Dos Santos, Antonia Thassya</creator><creator>Felix de Oliveira, Tatiana</creator><creator>Dos Santos, Franz de Assis G</creator><creator>Silva Buonafina, Maria Daniela</creator><creator>Melo Coutinho, Henrique Douglas</creator><creator>Alencar de Menezes, Irwin Rose</creator><creator>Bezerra Morais-Braga, Maria Flaviana</creator><creator>Pereira Neves, Rejane</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5722-090X</orcidid><orcidid>https://orcid.org/0000-0002-6634-4207</orcidid><orcidid>https://orcid.org/0000-0003-1065-9581</orcidid></search><sort><creationdate>20191204</creationdate><title>Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs</title><author>de Freitas, Maria Audilene ; Silva Alves, Adryelle Idalina ; Andrade, Jacqueline Cosmo ; Leite-Andrade, Melyna Chaves ; Lucas Dos Santos, Antonia Thassya ; Felix de Oliveira, Tatiana ; Dos Santos, Franz de Assis G ; Silva Buonafina, Maria Daniela ; Melo Coutinho, Henrique Douglas ; Alencar de Menezes, Irwin Rose ; Bezerra Morais-Braga, Maria Flaviana ; Pereira Neves, Rejane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-780c13ab1016380037363570e2bf591270274458d865176e0b10fdc4a0e7d4953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acrylic resins</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antimicrobial agents</topic><topic>Biofilms</topic><topic>Candida</topic><topic>Candida krusei</topic><topic>Chromatography</topic><topic>Composition</topic><topic>Control</topic><topic>Dimers</topic><topic>Enzymes</topic><topic>Evaluation</topic><topic>Extracellular matrix</topic><topic>Flavonoids</topic><topic>Fluconazole</topic><topic>Fungicides</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>High performance liquid chromatography</topic><topic>Infections</topic><topic>Isoflavones</topic><topic>Leaves</topic><topic>Liquid chromatography</topic><topic>Magnoliopsida</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicinal plants</topic><topic>Microbial mats</topic><topic>Microorganisms</topic><topic>Minimum inhibitory concentration</topic><topic>Pathogens</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Planktonic cells</topic><topic>Quadrupoles</topic><topic>Quercetin</topic><topic>Scientific imaging</topic><topic>Spectroscopy</topic><topic>Time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Freitas, Maria Audilene</creatorcontrib><creatorcontrib>Silva Alves, Adryelle Idalina</creatorcontrib><creatorcontrib>Andrade, Jacqueline Cosmo</creatorcontrib><creatorcontrib>Leite-Andrade, Melyna Chaves</creatorcontrib><creatorcontrib>Lucas Dos Santos, Antonia Thassya</creatorcontrib><creatorcontrib>Felix de Oliveira, Tatiana</creatorcontrib><creatorcontrib>Dos Santos, Franz de Assis G</creatorcontrib><creatorcontrib>Silva Buonafina, Maria Daniela</creatorcontrib><creatorcontrib>Melo Coutinho, Henrique Douglas</creatorcontrib><creatorcontrib>Alencar de Menezes, Irwin Rose</creatorcontrib><creatorcontrib>Bezerra Morais-Braga, Maria Flaviana</creatorcontrib><creatorcontrib>Pereira Neves, Rejane</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antibiotics (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Freitas, Maria Audilene</au><au>Silva Alves, Adryelle Idalina</au><au>Andrade, Jacqueline Cosmo</au><au>Leite-Andrade, Melyna Chaves</au><au>Lucas Dos Santos, Antonia Thassya</au><au>Felix de Oliveira, Tatiana</au><au>Dos Santos, Franz de Assis G</au><au>Silva Buonafina, Maria Daniela</au><au>Melo Coutinho, Henrique Douglas</au><au>Alencar de Menezes, Irwin Rose</au><au>Bezerra Morais-Braga, Maria Flaviana</au><au>Pereira Neves, Rejane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs</atitle><jtitle>Antibiotics (Basel)</jtitle><addtitle>Antibiotics (Basel)</addtitle><date>2019-12-04</date><risdate>2019</risdate><volume>8</volume><issue>4</issue><spage>250</spage><pages>250-</pages><issn>2079-6382</issn><eissn>2079-6382</eissn><abstract>sp. treatment has become a challenge due to the formation of biofilms which favor resistance to conventional antifungals, making the search for new compounds necessary. The objective of this study was to identify the composition of the
Benth. leaf ethanolic extract and to verify its antifungal activity against
sp. and its biofilms. The composition identification was performed using the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technique. The antifungal activity of extract and fluconazole against planktonic cells and biofilms was verified through the minimum inhibitory concentration (MIC) following biofilm induction and quantification in acrylic resin discs by reducing tetrazolic salt, with all isolates forming biofilms within 48 h. Six constituents were identified in the extract, and the compounds identified are derivatives from phenolic compounds such as flavonoids (epi) gallocatechin Dimer, epigallocatechin and gallocatechin, Myricetin-O-hexoside, Myricitrin, and Quercetin-O-rhamnoside. The extract reduced biofilm formation in some of the strains analyzed, namely
URM5732,
INCQS40042, and
URM6352. This reduction was also observed in the treatment with fluconazole with some of the analyzed strains. The extract showed significant antifungal and anti-biofilm activities with some of the strains tested.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31817228</pmid><doi>10.3390/antibiotics8040250</doi><orcidid>https://orcid.org/0000-0001-5722-090X</orcidid><orcidid>https://orcid.org/0000-0002-6634-4207</orcidid><orcidid>https://orcid.org/0000-0003-1065-9581</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Antibiotics (Basel), 2019-12, Vol.8 (4), p.250 |
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| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Acrylic resins Antifungal activity Antifungal agents Antimicrobial agents Biofilms Candida Candida krusei Chromatography Composition Control Dimers Enzymes Evaluation Extracellular matrix Flavonoids Fluconazole Fungicides Health aspects Herbal medicine High performance liquid chromatography Infections Isoflavones Leaves Liquid chromatography Magnoliopsida Mass spectrometry Mass spectroscopy Medicinal plants Microbial mats Microorganisms Minimum inhibitory concentration Pathogens Phenolic compounds Phenols Planktonic cells Quadrupoles Quercetin Scientific imaging Spectroscopy Time |
| title | Evaluation of the Antifungal Activity of the Licania Rigida Leaf Ethanolic Extract against Biofilms Formed by Candida Sp. Isolates in Acrylic Resin Discs |
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