Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain

Exposure to acrylamide may lead to different neurotoxic effects in humans and in experimental animals. To gain insights into this poorly understood type of neurotoxicological damage, we used a multi-omic approach to characterize the molecular changes occurring in the zebrafish brain exposed to acryl...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.312, Article 312
Hauptverfasser:	Raldúa, Demetrio, Casado, Marta, Prats, Eva, Faria, Melissa, Puig-Castellví, Francesc, Pérez, Yolanda, Alfonso, Ignacio, Hsu, Chuan-Yu, Arick II, Mark A., Garcia-Reyero, Natàlia, Ziv, Tamar, Ben-Lulu, Shani, Admon, Arie, Piña, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/570 631/1647/2017 631/1647/2067 631/1647/320 Acrylamide Acrylamide - toxicity Adducts Analytical chemistry Animals Biochemistry, Molecular Biology Brain - drug effects Brain - metabolism Chemical Sciences Gene Expression Regulation - drug effects Glutathione Glutathione - metabolism Humanities and Social Sciences Inactivation Life Sciences Metabolism Metabolites Metabolome - drug effects Microtubules Mode of action multidisciplinary Neurotoxicity Oxidation-Reduction Proteome - analysis Proton Magnetic Resonance Spectroscopy Science Science (multidisciplinary) Thioredoxin Thioredoxins - metabolism Transcription Zebrafish - metabolism Zebrafish Proteins - metabolism
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