The Plasticity of Newly Formed B Cells

Newly formed B cells (NF-B cells) that emerge from the bone marrow to the periphery have often been referred to as immature or transitional B cells. However, NF-B cells have several striking characteristics, including a distinct BCR repertoire, high expression of AID, high sensitivity to PAMPs, and...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-12, Vol.203 (12), p.3095-3104
Hauptverfasser:	Giltiay, Natalia V, Giordano, Daniela, Clark, Edward A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - immunology Autoimmunity Cell Plasticity - physiology Cytidine Deaminase - metabolism Humans Immunoglobulin Class Switching - immunology Infections - immunology Lupus Erythematosus, Systemic - immunology Lymphocyte Activation - immunology Mice Precursor Cells, B-Lymphoid - immunology Precursor Cells, B-Lymphoid - metabolism
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